Ebook: Toxoplasmosis

Toxoplasma gondii is an important parasite causing economic losses in agriculture, congenital abnormalities in man and fatal disease in immunosuppressed individuals. Recently there has been a resurgence of interest in the parasite. This is partially due to the increased clinical importance of toxoplasmosis: the disease kills 25 % of AIDS patients. However, hit is also because the parasite provides a tractable model system for molecular, cellular and immunological investigation of intracellular parasites. The book is divided into four sections: three basic science sections on molecular biology, cell biology, and immunology of toxoplasmosis, with a final section reviewing applied issues such as vaccination, chemotherapy, and diagnosis.

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Toxoplasma gondii is an important parasite causing economic losses in agriculture, congenital abnormalities in man and fatal disease in immunosuppressed individuals. Recently there has been a resurgence of interest in the parasite. This is partially due to the increased clinical importance of toxoplasmosis: the disease kills 25 % of AIDS patients. However, hit is also because the parasite provides a tractable model system for molecular, cellular and immunological investigation of intracellular parasites. The book is divided into four sections: three basic science sections on molecular biology, cell biology, and immunology of toxoplasmosis, with a final section reviewing applied issues such as vaccination, chemotherapy, and diagnosis.
Content:
Front Matter....Pages I-XV
Front Matter....Pages 1-1
Allelic Polymorphyism in Toxoplasma Gondii Implications for Interstrain Mating....Pages 3-8
Study of Genetic Polymorphism of Toxoplasma Gondii Through Isoenzyme Analysis....Pages 9-17
Expression of Apical Organelles Antigens by a Toxoplasma Gondii Genomic Library....Pages 19-31
Extrachromosomal DNA in the Apicomplexa....Pages 33-41
Front Matter....Pages 43-50
The Parasitophorous Vacuole Membrane Surrounding T. Gondii: A Specialized Interface Between Parasite and Cell....Pages 51-60
Front Matter....Pages 61-61
Factors Responsible for Development of Toxoplasmic Enchephalitis in Immunocompromised Hosts....Pages 63-72
Protection of Mice and Nude Rats Against Toxoplasmosis by an Octameric Construct of the P30 48–67 Peptide....Pages 73-81
Front Matter....Pages 83-92
Synergistic Drug Combinations in the Treatment of Toxoplasmosis....Pages 93-98
Front Matter....Pages 99-108
Diagnosis of Toxoplasma Gondii Infections by Molecular Detection....Pages 109-121
Use of Toxoplasma Gondii Recombinant Antigens for Diagnosis and Seroepidemiology....Pages 123-123
Progress Towards the Development of a Vaccine Against Congenital Toxplamosis: Identification of Protective Antigens and the Selection of Appropriate Adjuvants....Pages 125-130
Development of a Live Vaccine Against Ovine Toxoplasmosis....Pages 131-151
Genetic Regulation of Toxoplasma Gondii Infection: Influence of LSH/ITY/BCG Gene....Pages 153-156
Mucosal Immune Response in Toxoplasmosis....Pages 157-162
Antenatal Screening for Toxoplasmosis in Turkiye....Pages 163-168
Toxoplasmosis in Greece: Serological Studies....Pages 169-177
Critical Evaluation of IGA Antibodies as an Indication of Early Toxoplasma-Infection....Pages 179-179
Expression of Toxoplasma Gondii Genes in rBCG....Pages 181-190
Back Matter....Pages 191-198
....Pages 179-179