Ebook: Cellular and Molecular Biology of Atherosclerosis

Atherosclerotic cardiovascular disease remains the major cause of death and disability in Western society. The field of atherosclerosis research has grown tremendously over the last forty years, shedding a great deal of light on the contributing factors and natural history of the disorder and enabling strategies for its treatment and prevention. Some of the greatest strides in this field in recent years have derived from advances in molecular biology techniques. These strides were chosen for emphasis in the most recent Princess Lilian symposium, whose proceedings this volume represents. Historically, the Princess Lilian meetings have been small ones aimed at bringing together investigators from diverse specialties to discuss a particular subject. The most recent meeting was no exception and included clinicians, clinical investigators, and research­ ers in basic science. The symposium began with an extensive review of coronary morphopathological findings in patients who died of coronary heart disease. Any rational hypothesis of atherogenesis must take into account clinical findings, and any attempt to bridge the gap between experimental laboratory findings and studies in man is highly desirable. Three chapters focus on endothelial injury: one on the nitric oxide pathway in physiology and pathology, a second on the activation of endothelial cells, and a third on the monocyte and endothelial injury. Still another chapter examines growth factors, in particular the fibroblast growth factor in atherogenesis.

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Content:
Front Matter....Pages i-xv
Morphological Findings in the Coronary Arteries in Fatal Coronary Artery Disease....Pages 1-20
The L-Arginine: Nitric Oxide Pathway in Physiology and Pathology....Pages 21-35
Endothelial Activation: Its Role in Inflammation, Vascular Injury and Atherogenesis....Pages 37-44
Basic Fibroblast Growth Factor in Vascular Development and Atherogenesis....Pages 45-59
The Monocyte and Endothelial Injury in Atherogenesis....Pages 61-69
Lp [a]: A Lipoprotein Class with Atherothrombotic Potential....Pages 71-76
Modified Lipoproteins and Atherogenesis....Pages 77-81
The Molecular Biology of Apolipoprotein B....Pages 83-92
Structure and Evolution of the Apolipoprotein and Lipase Gene Families....Pages 93-107
A Gln to Arg Substitution in the Adducin Family of Proteins is a Necessary but not Sufficient Factor for High Blood Pressure in Rats of the Milan Hypertensive Strain....Pages 109-119
Genetic Control of Plasma Lipid, Lipoprotein and Apolipoprotein Levels: From Restriction Fragment Length Polymorphisms to Specific Mutations....Pages 121-133
Receptor Regulation of Lipoprotein Metabolism....Pages 135-143
The High-Density Lipoprotein Receptor....Pages 145-152
High-Density Lipoprotein Cholesterol, Triglycerides and Coronary Heart Disease....Pages 153-157
Apolipoproteins, Reverse Cholesterol Transport and Coronary Heart Disease....Pages 159-166
Cholesterol-Lowering Clinical Trials: Where Do We Go From Here?....Pages 167-176
Back Matter....Pages 177-180

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Content:
Front Matter....Pages i-xv
Morphological Findings in the Coronary Arteries in Fatal Coronary Artery Disease....Pages 1-20
The L-Arginine: Nitric Oxide Pathway in Physiology and Pathology....Pages 21-35
Endothelial Activation: Its Role in Inflammation, Vascular Injury and Atherogenesis....Pages 37-44
Basic Fibroblast Growth Factor in Vascular Development and Atherogenesis....Pages 45-59
The Monocyte and Endothelial Injury in Atherogenesis....Pages 61-69
Lp [a]: A Lipoprotein Class with Atherothrombotic Potential....Pages 71-76
Modified Lipoproteins and Atherogenesis....Pages 77-81
The Molecular Biology of Apolipoprotein B....Pages 83-92
Structure and Evolution of the Apolipoprotein and Lipase Gene Families....Pages 93-107
A Gln to Arg Substitution in the Adducin Family of Proteins is a Necessary but not Sufficient Factor for High Blood Pressure in Rats of the Milan Hypertensive Strain....Pages 109-119
Genetic Control of Plasma Lipid, Lipoprotein and Apolipoprotein Levels: From Restriction Fragment Length Polymorphisms to Specific Mutations....Pages 121-133
Receptor Regulation of Lipoprotein Metabolism....Pages 135-143
The High-Density Lipoprotein Receptor....Pages 145-152
High-Density Lipoprotein Cholesterol, Triglycerides and Coronary Heart Disease....Pages 153-157
Apolipoproteins, Reverse Cholesterol Transport and Coronary Heart Disease....Pages 159-166
Cholesterol-Lowering Clinical Trials: Where Do We Go From Here?....Pages 167-176
Back Matter....Pages 177-180
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