Ebook: Pancreatic Islet Cell Regeneration and Growth

Aaron I. Vinik, M.D., Ph.D. I IEastem Virginia Medical School The Diabetes Institutes Norfolk, Virginia 23510 This symposium, held in June 1991, was a gathering of international scientists to exchange their views on current concepts of cell growth and differentiation. Each scientist was asked to present a topic of their research related to cell growth and regeneration and to participate in a round table conference elaborating on current knowledge and sharing their experiences. By furthering this promising area of endeavor, a means of understanding ontogeny of cell development and of providing insights into tumor biology would prevail. Of prime importance was the anticipation that new information from a better understanding of the normal evolution of the pancreatic islet would generate alternative approaches to curing diabetes. This forward serves as a short introduction to the concept of pancreatic islet regeneration and the models currently in use to study the process. DEVELOPMENTAL ORIGIN OF ISLETS DURING EMRYOGENESIS The developing pancreas appears as a protrusion from the dorsal surface of the l embryonic gut. The different islet cell types appear sequentially during development in vivo. It therefore seems reasonable to propose that coordinated growth is dependent upon specificity of growth factors.

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Content:
Front Matter....Pages i-ix
Introduction....Pages 1-5
Front Matter....Pages 7-7
The Role of Growth Hormone and Prolactin in Beta Cell Growth and Regeneration....Pages 9-20
The Insulin-Like Growth Factor Family of Peptides, Binding Proteins and Receptors: Their Potential Role in Tissue Regeneration....Pages 21-30
The Effects of IGF-I and IGF-II on Cell Growth and Differentiation in the Central Nervous System....Pages 31-36
Growth Factor Expression in Normal and Diabetic Rats During Peripheral Nerve Regeneration through Silicone Tubes....Pages 37-44
Oncogenes and Cell Growth....Pages 45-51
Interferon — A Candidate Mediator of Cell Growth....Pages 53-58
Front Matter....Pages 59-59
Islet ?-Cell Regeneration and Reg Genes....Pages 61-69
Factors Regulating Islet Regeneration in the Post-Insulinoma NEDH Rat....Pages 71-84
Regeneration of Pancreatic Endocrine Cells in Interferon-Gamma Transgenic Mice....Pages 85-93
Trophic Stimulation of the Ductular-Islet Cell Axis: A New Approach to the Treatment of Diabetes....Pages 95-109
Front Matter....Pages 111-111
Expression of Insulin-Like Growth Factors (IGFs) and Their Binding Proteins (IGF BPs) During Pancreatic Development in Rat, and Modulation of IGF Actions on Rat Islet DNA Synthesis by IGF BPs....Pages 113-122
The Partial Isolation and Characterization of Ilotropin, a Novel Islet-Specific Growth Factor....Pages 123-132
Expression of Growth Factors in a Pancreatic Islet Regeneration Model....Pages 133-141
Role of p21 ras in Hormone Signalling and Cell Growth/Transformation....Pages 143-146
Phosphoinositides and Cell Growth....Pages 147-151
The Physiological Stop Pathway: Target Regulation of Axonal Growth....Pages 153-157
Calcium Regulation of Myosin I — A Motor for Membrane Movement....Pages 159-163
Front Matter....Pages 165-165
Amylin Expression in the Pancreatic ?-Cell....Pages 167-169
Studies of Composite Grafts of Fetal Pancreas (FP) and Fetal Liver (FL) in the Streptozotocin-Induced Diabetic Rat....Pages 171-177
Back Matter....Pages 179-187

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Content:
Front Matter....Pages i-ix
Introduction....Pages 1-5
Front Matter....Pages 7-7
The Role of Growth Hormone and Prolactin in Beta Cell Growth and Regeneration....Pages 9-20
The Insulin-Like Growth Factor Family of Peptides, Binding Proteins and Receptors: Their Potential Role in Tissue Regeneration....Pages 21-30
The Effects of IGF-I and IGF-II on Cell Growth and Differentiation in the Central Nervous System....Pages 31-36
Growth Factor Expression in Normal and Diabetic Rats During Peripheral Nerve Regeneration through Silicone Tubes....Pages 37-44
Oncogenes and Cell Growth....Pages 45-51
Interferon — A Candidate Mediator of Cell Growth....Pages 53-58
Front Matter....Pages 59-59
Islet ?-Cell Regeneration and Reg Genes....Pages 61-69
Factors Regulating Islet Regeneration in the Post-Insulinoma NEDH Rat....Pages 71-84
Regeneration of Pancreatic Endocrine Cells in Interferon-Gamma Transgenic Mice....Pages 85-93
Trophic Stimulation of the Ductular-Islet Cell Axis: A New Approach to the Treatment of Diabetes....Pages 95-109
Front Matter....Pages 111-111
Expression of Insulin-Like Growth Factors (IGFs) and Their Binding Proteins (IGF BPs) During Pancreatic Development in Rat, and Modulation of IGF Actions on Rat Islet DNA Synthesis by IGF BPs....Pages 113-122
The Partial Isolation and Characterization of Ilotropin, a Novel Islet-Specific Growth Factor....Pages 123-132
Expression of Growth Factors in a Pancreatic Islet Regeneration Model....Pages 133-141
Role of p21 ras in Hormone Signalling and Cell Growth/Transformation....Pages 143-146
Phosphoinositides and Cell Growth....Pages 147-151
The Physiological Stop Pathway: Target Regulation of Axonal Growth....Pages 153-157
Calcium Regulation of Myosin I — A Motor for Membrane Movement....Pages 159-163
Front Matter....Pages 165-165
Amylin Expression in the Pancreatic ?-Cell....Pages 167-169
Studies of Composite Grafts of Fetal Pancreas (FP) and Fetal Liver (FL) in the Streptozotocin-Induced Diabetic Rat....Pages 171-177
Back Matter....Pages 179-187
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