Ebook: Immunobiology of Proteins and Peptides VI: Human Immunodeficiency Virus, Antibody Immunoconjugates, Bacterial Vaccines, and Immunomodulators

The articles in this volume represent papers delivered by invited speakers at the 6th International Symposium on the Immunobiology of Proteins and Peptides. In addition, a few of the abstracts submitted by participants were scheduled for minisymposia and some of the authors, whose presentations were judged by the Scientific Council to be of high quality, were invited to submit papers for publication in this volume. This symposium was established in 1976 for the purpose of bringing together, once every two or three years, active investigators in the forefront of contemporary immunology, to present their findings and discuss t heir significance in the light of current concepts and to identify important new directions of investigation. The founding of the symposium was stimulated by the achievement of major breakthroughs in the understanding of the immune recognition of proteins and peptides. We believed that these breakthroughs will lead to the creation of a new generation of peptide reagents which should have enormous potential in biological, therapeutic and basic applications. This anticipated explosion has in fact since occurred and many applications of these pep tides are now being realized.

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Content:
Front Matter....Pages i-xiii
Structure and Function in Recombinant HIV-1 gp120 and Speculation about the Disulfide Bonding in the gp120 Homologs of HIV-2 and SIV....Pages 1-14
The Lentivirus Regulatory Proteins REV and REX are Site Specific RNA Binding Proteins....Pages 15-22
HIV-1 Neutralizing Antibody and Approaches to the Envelope Diversity Problem....Pages 23-26
Molecular Mechanisms in the Pathogenesis of AIDS-Associated Kaposi’s Sarcoma....Pages 27-38
Structure-Function Analysis of the HIV Glycoprotein....Pages 39-46
Maternal Antibody Epitope Mapping in Mother-to-Child Transmission of HIV....Pages 47-52
Immunogenicity of Synthetic Peptides Corresponding to Various Epitopes of the Human Immunodeficiency Virus Envelope Protein....Pages 53-62
Common Sequence in HIV-1 GP41 and HLA Class II Beta Chains can Generate Crossreactive Autoantibodies with Immunosuppressive Potential Early in the Course of HIV-1 Infection....Pages 63-69
Isolation and Characterization of the Neutralizable Epitope of Simian Retrovirus-1 (SRV-1) and of the Cell Receptor for the Virus....Pages 71-77
Complexes and Conjugates of cis-Pt for Immunotargeted Chemotherapy....Pages 79-90
Radiolabeled Antibody Therapy of Human B Cell Lymphomas....Pages 91-96
Activation of Prodrugs by Antibody-Enzyme Conjugates....Pages 97-105
Cancer Imaging and Therapy with Radiolabeled Antibodies....Pages 107-117
Genetic Approaches to a Vaccine for Pertussis....Pages 119-127
Immunoprophylaxis of Otitis Media....Pages 129-148
Protection against Streptococcal Pharyngeal Colonization with Vaccines Composed of M Protein Conserved Regions....Pages 149-158
Oral Delivery of Antigens in Live Bacterial Vectors....Pages 159-167
Augmentation by Interleukins of the Antibody Response to a Conjugate Vaccine against Haemophilus influenzae B....Pages 169-184
Factors Produced by Stromal Cells Involved in B-Cell Development....Pages 185-190
Suppressor T Cells Induced in Vivo by Tolerogenic Conjugates of a Given Antigen and Monomethoxypolyethylene Glycol Downregulate Antibody Formation Also to a Second Antigen, if the Latter is Presented as a Covalent Adduct with the Former....Pages 191-197
A Purified Saponin Acts as an Adjuvant for a T-Independent Antigen....Pages 199-206
Modified-Live Infectious Bovine Rhinotracheitis Virus (IBRV) Vaccine Expressing Foot-and-Mouth Disease Virus (FMDV) Capsid Protein Epitopes on Surface of Hybrid Virus Particles....Pages 207-210
Development of Non-Toxigenic Vaccine Strains of Bordetella pertussis by Gene Replacement....Pages 211-220
Immunogenicity of Lipopolysaccharide Derived from Brucella abortus: Potential as a Carrier in Development of Vaccines for AIDS....Pages 221-225
Antigenic Mapping of Light Chains and T Cell Receptor ? Chains....Pages 227-233
Epitope Mapping Studies of Snake Venom Phospholipase A2 Using Monoclonal Antibodies....Pages 235-242
Identification of Epitopes of the Receptor Binding Subunit of Cholera Toxin by Synthetic Peptide and CBIB Approaches....Pages 243-248
Autoimmune Recognition Profile of the Alpha Chain of Human Acetylcholine Receptor in Myasthenia Gravis....Pages 249-254
Paucity of Humoral Response in Patients to Glioma-Associated Antigen(s): Antigen Localization by Immunofluorescence....Pages 255-261
Preparation and Characterization of Antisera and of Murine Monoclonal Antibodies to Human Glioma-Associated Antigen(s)....Pages 263-270
A Peptide Antibody that Specifically Inhibits Cathepsin L....Pages 271-283
Immunomodulating Properties of Corticotropin-Releasing Factor....Pages 285-288
Back Matter....Pages 289-293
....Pages 295-298