Ebook: Boundaries between Promotion and Progression during Carcinogenesis

The pUrpOSE! of this conference was not to define the two areas that are being bound, which might be a well nigh impossible proposition. Rather, its focus was to concentrate on the mechanistic similarities between promotion and progression. Are the areas involved within the boundaries a continuum? Are these two simultaneous processes? Or are some of the affected cells in the stage of promotion when at the same time others have undergone irreversi­ ble changes tha. t position them in the stage of progression? Or are these two stages the same thing, but called by different names? To explore such concepts we assembled investigators with various back­ grounds and asked them to specifically address these and other questions about "The Boundaries", within the context of the session to which they con­ tributed. The conference lasted two and a half days, from Wednesday to Friday. There were at least four speakers per session with morning and after­ noon sessions each day, except on Friday when the meeting ended at noon. The first day, each speaker had 25 minutes to present a position, followed by five minutes of discussion. At the end of the session there were 40 or 50 minutes of exchange on all the issues examined. For the remaining days, there were 25 minutes of presentation and 15 minutes of discussion.

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Content:
Front Matter....Pages i-xi
Introduction: Is There a Boundary between Promotion and Progression?....Pages 1-2
Characterization of the Stage of Progression in Hepatocarcinogenesis in the Rat....Pages 3-18
Critical Events in Skin Tumor Promotion and Progression....Pages 19-29
Malignant Conversion, the First Stage in Progression, is Distinct from Phorbol Ester Promotion in Mouse Skin....Pages 31-42
Boundaries in Mammary Carcinogenesis....Pages 43-59
Discussion of Session....Pages 61-69
Progression in Teratocarcinomas....Pages 71-81
Developmental Potential of Murine Pluripotential Stem Cells....Pages 83-99
Summary by Moderator....Pages 101-101
Tumor Progression in Transgenic Mice Containing the Bovine Papillomavirus Genome....Pages 103-110
SV40 T Antigen Transgenic Mice: Cytotoxic T Lymphocytes as a Selective Force in Tumor Progression....Pages 111-125
Differential Gene Expression During Tumor Promotion and Progression in the Mouse Skin Model....Pages 127-141
Oncogenes and Breast Cancer Progression....Pages 143-156
Gene Amplification During Stages of Carcinogenesis....Pages 157-170
Recessive Mutations in Cancer Predisposition and Progression....Pages 171-181
Role of Tumor Suppressor Genes in a Multistep Model of Carcinogenesis....Pages 183-196
Cancer Genes by Non-Homologous Recombination....Pages 197-211
Summary Discussion....Pages 213-219
Genetic Instability and Tumor Development....Pages 221-231
Unknown Primary Tumors: An Example of Accelerated (Type 2) Tumor Progression....Pages 233-240
Summary by Moderator....Pages 241-241
Tumor Heterogeneity and Intrinsically Chemoresistant Subpopulations in Freshly Resected Human Malignant Gliomas....Pages 243-262
Genetic Instability Occurs Sooner Than Expected: Promotion, Progression and Clonality During Hepatocarcinogenesis in the Rat....Pages 263-277
Clonal Analysis of Neoplastic Transformation in Cultured Diploid Rat Liver Epithelial Cells....Pages 279-300
Epigenetic Features of Spontaneous Transformation in the NIH 3T3 Line of Mouse Cells....Pages 301-313
The Human Melanocyte System as a Model for Studies on Tumor Progression....Pages 315-328
Early and Late Events in the Development of Human Breast Cancer....Pages 329-340
Malignant Progression of Harvey RAS Transformed Normal Human Bronchial Epithelial Cells....Pages 341-354
Identification and Characterization of Differentially Expressed Genes in Tumor Metastasis: The nm23 Gene....Pages 355-361
Back Matter....Pages 363-372

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Content:
Front Matter....Pages i-xi
Introduction: Is There a Boundary between Promotion and Progression?....Pages 1-2
Characterization of the Stage of Progression in Hepatocarcinogenesis in the Rat....Pages 3-18
Critical Events in Skin Tumor Promotion and Progression....Pages 19-29
Malignant Conversion, the First Stage in Progression, is Distinct from Phorbol Ester Promotion in Mouse Skin....Pages 31-42
Boundaries in Mammary Carcinogenesis....Pages 43-59
Discussion of Session....Pages 61-69
Progression in Teratocarcinomas....Pages 71-81
Developmental Potential of Murine Pluripotential Stem Cells....Pages 83-99
Summary by Moderator....Pages 101-101
Tumor Progression in Transgenic Mice Containing the Bovine Papillomavirus Genome....Pages 103-110
SV40 T Antigen Transgenic Mice: Cytotoxic T Lymphocytes as a Selective Force in Tumor Progression....Pages 111-125
Differential Gene Expression During Tumor Promotion and Progression in the Mouse Skin Model....Pages 127-141
Oncogenes and Breast Cancer Progression....Pages 143-156
Gene Amplification During Stages of Carcinogenesis....Pages 157-170
Recessive Mutations in Cancer Predisposition and Progression....Pages 171-181
Role of Tumor Suppressor Genes in a Multistep Model of Carcinogenesis....Pages 183-196
Cancer Genes by Non-Homologous Recombination....Pages 197-211
Summary Discussion....Pages 213-219
Genetic Instability and Tumor Development....Pages 221-231
Unknown Primary Tumors: An Example of Accelerated (Type 2) Tumor Progression....Pages 233-240
Summary by Moderator....Pages 241-241
Tumor Heterogeneity and Intrinsically Chemoresistant Subpopulations in Freshly Resected Human Malignant Gliomas....Pages 243-262
Genetic Instability Occurs Sooner Than Expected: Promotion, Progression and Clonality During Hepatocarcinogenesis in the Rat....Pages 263-277
Clonal Analysis of Neoplastic Transformation in Cultured Diploid Rat Liver Epithelial Cells....Pages 279-300
Epigenetic Features of Spontaneous Transformation in the NIH 3T3 Line of Mouse Cells....Pages 301-313
The Human Melanocyte System as a Model for Studies on Tumor Progression....Pages 315-328
Early and Late Events in the Development of Human Breast Cancer....Pages 329-340
Malignant Progression of Harvey RAS Transformed Normal Human Bronchial Epithelial Cells....Pages 341-354
Identification and Characterization of Differentially Expressed Genes in Tumor Metastasis: The nm23 Gene....Pages 355-361
Back Matter....Pages 363-372
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