Ebook: T Lymphocytes: Structure, Functions, Choices

This volume contains the proceedings of the NATO Advanced Study Institute held in Porto Conte (Alghero), Sardinia, September 15-27, 1991. The A. S. 1. was attended by 86 graduate and postgraduate students from 18 different countries, and was hosted by the newly founded International Laboratory of Molecular Genetics of Porto Conte, directed by Prof. Marcello Siniscalco. The A. S. I. was funded by NATO Scientific Affairs Division, the International Union of Immunological Societies, the European Community (Directorate General for Science, Research and Development), the Italian Research Council, and the San Raffaele Institute of Milano. In addition, a number of students who reside in the U. S. received travel funds from the U. S. National Science Foundation, and the Turkish National Fund provided financial assistance to several students from Turkey. When we decided to organize a course on T lymphocytes, our concern was to reach a balance between the teaching of both the hard core principles and the latest experimental findings of cellular immunology, and the recently expanded interfaces with the not-yet­ known: hypotheses, speCUlations, new projections to be born from the discussions.

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Content:
Front Matter....Pages i-xi
T-Cell Antigen and MHC Recognition: Molecular Analysis of Human ?/? TCR Specific for a Tetanus Toxin-Derived Peptide....Pages 1-16
Structure of the TCR-Ag-MHC Complex....Pages 17-23
Is Recognition by the T Cell Receptor Highly Constrained or Very Degenerate?....Pages 25-35
Characteristics of Foreign and Self Peptides Endogenously Bound to MHC Class I Molecules....Pages 37-43
Positive and Negative Selection of T Cells....Pages 45-60
Peripheral Tolerance....Pages 61-69
The Functional Relationship between Preferential Use of Newly Synthesized Class II Molecules and Their Stable Association with Peptides....Pages 71-74
Epitope Selection and Autoimmunity....Pages 75-87
HLA-A2 Allorecognition and Subtype Diversification....Pages 89-95
On the Antigenicity of Antibody Idiotypes....Pages 97-104
Idiotype Interactions between T Cells....Pages 105-110
A Network of Self Interactions....Pages 111-120
Stimulation of Lymphocytes by Anti-Idiotypes Bearing the Internal Image of Viral Antigens....Pages 121-133
Cloned Suppressor T Cells --- Their Identity, Functions, and Mediators....Pages 135-144
The Autoreactive T Cell Receptor: Structure and Biological Activity....Pages 145-151
The Relationship between Diabetes and Lymphopenia in the BB Rat....Pages 153-161
RT6, an Unusually Polymorphic T-Cell Specific Membrane Protein Linked to Type I Autoimmune Diabetes in Rats and Mice....Pages 163-167
Alternative Pathways of Signal Transduction after Ligation of the TCR by Bacterial Superantigen....Pages 169-177
Molecular Analysis of the Interactions between Staphylococcal Enterotoxin a Superantigen and the Human MHC Class II Molecules....Pages 179-185
Immunosuppression by MHC Class II Blockade....Pages 187-194
Recognition of HIV Antigens by Human T Helper Cells....Pages 195-205
Proliferative Responses to the V3 Region of HIV Envelope Are Enhanced Following Immunization with V3:Ty Virus-Like Particles in Mice....Pages 207-214
Teaching Immunology: A Montessori Approach using a Computer Model of the Immune System....Pages 215-225
Modelling T Cell Memory in Vivo and in Vitro....Pages 227-234
Oligoclonal T Cells Expressing the TCR V-? 6 Gene Product Following IL-2 Culture of Ovarian Carcinoma Derived Lymphocytes....Pages 235-240
Comparisons of the V-Delta-1 Expressing T-Cells in Synovial Fluid and Peripheral Blood of Patients with Chronic Arthritis....Pages 241-246
Bispecific Monoclonal Antibody Targeted Cytotoxic T Lymphocytes can Recycle....Pages 247-249
Back Matter....Pages 251-256

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Content:
Front Matter....Pages i-xi
T-Cell Antigen and MHC Recognition: Molecular Analysis of Human ?/? TCR Specific for a Tetanus Toxin-Derived Peptide....Pages 1-16
Structure of the TCR-Ag-MHC Complex....Pages 17-23
Is Recognition by the T Cell Receptor Highly Constrained or Very Degenerate?....Pages 25-35
Characteristics of Foreign and Self Peptides Endogenously Bound to MHC Class I Molecules....Pages 37-43
Positive and Negative Selection of T Cells....Pages 45-60
Peripheral Tolerance....Pages 61-69
The Functional Relationship between Preferential Use of Newly Synthesized Class II Molecules and Their Stable Association with Peptides....Pages 71-74
Epitope Selection and Autoimmunity....Pages 75-87
HLA-A2 Allorecognition and Subtype Diversification....Pages 89-95
On the Antigenicity of Antibody Idiotypes....Pages 97-104
Idiotype Interactions between T Cells....Pages 105-110
A Network of Self Interactions....Pages 111-120
Stimulation of Lymphocytes by Anti-Idiotypes Bearing the Internal Image of Viral Antigens....Pages 121-133
Cloned Suppressor T Cells --- Their Identity, Functions, and Mediators....Pages 135-144
The Autoreactive T Cell Receptor: Structure and Biological Activity....Pages 145-151
The Relationship between Diabetes and Lymphopenia in the BB Rat....Pages 153-161
RT6, an Unusually Polymorphic T-Cell Specific Membrane Protein Linked to Type I Autoimmune Diabetes in Rats and Mice....Pages 163-167
Alternative Pathways of Signal Transduction after Ligation of the TCR by Bacterial Superantigen....Pages 169-177
Molecular Analysis of the Interactions between Staphylococcal Enterotoxin a Superantigen and the Human MHC Class II Molecules....Pages 179-185
Immunosuppression by MHC Class II Blockade....Pages 187-194
Recognition of HIV Antigens by Human T Helper Cells....Pages 195-205
Proliferative Responses to the V3 Region of HIV Envelope Are Enhanced Following Immunization with V3:Ty Virus-Like Particles in Mice....Pages 207-214
Teaching Immunology: A Montessori Approach using a Computer Model of the Immune System....Pages 215-225
Modelling T Cell Memory in Vivo and in Vitro....Pages 227-234
Oligoclonal T Cells Expressing the TCR V-? 6 Gene Product Following IL-2 Culture of Ovarian Carcinoma Derived Lymphocytes....Pages 235-240
Comparisons of the V-Delta-1 Expressing T-Cells in Synovial Fluid and Peripheral Blood of Patients with Chronic Arthritis....Pages 241-246
Bispecific Monoclonal Antibody Targeted Cytotoxic T Lymphocytes can Recycle....Pages 247-249
Back Matter....Pages 251-256
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