Ebook: Uterine and Embryonic Factors in Early Pregnancy

Human reproduction is the most dynamic of processes. The events which lead to the birth of a normal healthy infant have their origin long before actual fertilization. Indeed, the whole process can be looked upon as a continuum. Human fertilization and early development, once sequestered in the protective environment of the fallopian tubes and uterus, have now been exposed in the laboratory. These events have, over time, been extensively observed and catalogued in animal models. The tools of modem morphology and molecular biology have reopened issues long since considered settled as facets of early reproduction are reexplored. This volume, consisting of the proceedings of a workshop on uterine and embryonic factors in early pregnancy, has been designed to enhance that effort. Attention is focused largely on early embryonal development with special attention to the interrelationship between the embryo and the uterus in early pregnancy. Each of the contributing scientists brings with him or her the perspective of one specific discipline or another. The common denominator is the application of emerging techniques in modem molecular biology to problems pertaining to embryonal-uterine interaction. The goal is to consider specific areas of concern in a multidisciplinary way and to reexplore the factors behind early development and implantation. Uterine complement, the function of uterine macrophages immunoregulatory loops in the peri-implantation period, colony stimulating factors and interferon-like factors are reviewed and their interrelationship explored. Uterine angiogenesis factors as well as embryonic growth factors are also considered.

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Oviductal Recognition of Embryonic Signals; H.B. Croxatto, et al. Effect of Progesterone Antagonists on Ovo-Endometrial Interactions; A.Psychoyos. On the Requirement for Estrogen for Establishing Pregnancy in the Non-Human Primate; N.R. Moudgal. Embryonic Loss and Conceptus Interferon Production; R.M. Roberts.In Vitro Models of Implantation; S.R. Glasser, et al. Uterine EGF Ligand-Receptor Circuitry and Its Role in EmbryoUterine Interactions during Implantation in the Mouse; S.K.Dey, et al. Human Uterine Angiogenic Factor (HUAF). The Role of Lymphohematopoietic Cytokines in Signalling between the Immune and Reproductive Systems; T.G. Wegmann. Human Decidual Function in Trophoblast and Uterine interaction; T. Mori, et al. Cytokines at the Maternal Fetal Interface: Colony Stimulating Factor1 as a Paradigm for the Maternal Regulation of Muridae Rodents; C. Tachi. Hormonal Regulation of Uterine Complement; K.B. Isaacson, et al. Insulinlike Growth Factor Binding Proteins: A Paradigm for Conceptus-Maternal Interactions in the Primate; A.T. Fazleabas, et al. The Roles of Growth Factors and Their Receptors in Peri-Implantation Mouse Embryos and at the Embryomaternal Interface; Z. Werb, et al. Ligands and Receptors of the Insulin Family: Role in Early Mammalian Development; S. Heyner, et al. 6 additional articles. Index.

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Oviductal Recognition of Embryonic Signals; H.B. Croxatto, et al. Effect of Progesterone Antagonists on Ovo-Endometrial Interactions; A.Psychoyos. On the Requirement for Estrogen for Establishing Pregnancy in the Non-Human Primate; N.R. Moudgal. Embryonic Loss and Conceptus Interferon Production; R.M. Roberts.In Vitro Models of Implantation; S.R. Glasser, et al. Uterine EGF Ligand-Receptor Circuitry and Its Role in EmbryoUterine Interactions during Implantation in the Mouse; S.K.Dey, et al. Human Uterine Angiogenic Factor (HUAF). The Role of Lymphohematopoietic Cytokines in Signalling between the Immune and Reproductive Systems; T.G. Wegmann. Human Decidual Function in Trophoblast and Uterine interaction; T. Mori, et al. Cytokines at the Maternal Fetal Interface: Colony Stimulating Factor1 as a Paradigm for the Maternal Regulation of Muridae Rodents; C. Tachi. Hormonal Regulation of Uterine Complement; K.B. Isaacson, et al. Insulinlike Growth Factor Binding Proteins: A Paradigm for Conceptus-Maternal Interactions in the Primate; A.T. Fazleabas, et al. The Roles of Growth Factors and Their Receptors in Peri-Implantation Mouse Embryos and at the Embryomaternal Interface; Z. Werb, et al. Ligands and Receptors of the Insulin Family: Role in Early Mammalian Development; S. Heyner, et al. 6 additional articles. Index.
Content:
Front Matter....Pages i-xiii
Oviductal Recognition of Embryonic Signals....Pages 1-6
Effect of Progesterone Antagonists on Ovo-Endometrial Interactions....Pages 7-11
On the Requirement for Estrogen for Establishing Pregnancy in the Non-Human Primate....Pages 13-19
Embryonic Loss and Conceptus Interferon Production....Pages 21-31
Uterine EGF Ligand-Receptor Signalling and Its Role in Embryo-Uterine Interactions during Implantation in the Mouse....Pages 33-50
Human Uterine Angiogenic Factor (HUAF)....Pages 51-69
The Role of Lymphohematopoietic Cytokines in Signalling between the Immune and Reproductive Systems....Pages 71-86
Human Decidual Function in Trophoblast and Uterine Interaction....Pages 87-95
Cytokines at the Maternal Fetal Interface: Colony Stimulating Factor-1 as a Paradigm for the Maternal Regulation of Pregnancy....Pages 97-105
Uterine Macrophages and Their Function in Implantation of Muridae Rodents....Pages 107-118
Hormonal Regulation of Uterine Complement....Pages 119-139
Insulin-Like Growth Factor Binding Proteins: A Paradigm for Conceptus-Maternal Interactions in the Primate....Pages 141-156
The Roles of Growth Factors and Their Receptors in Peri-Implantation Mouse Embryos and at the Embryomaternal Interface....Pages 157-165
Ligands and Receptors of the Insulin Family: Role in Early Mammalian Development....Pages 167-178
Does Human Syncytiotrophoblast Express the M-CSF Receptor/ C-fms Protein Product?....Pages 179-194
Oncogenes in Development: C-FOS and EGR-1 Studies in Embryonal Carcinoma Cells....Pages 195-204
The Molecular and Cellular Biology of Growth Stimulatory Pathways during Human Placental Development....Pages 205-218
Growth Factors in Placental Function....Pages 219-233
Human Trophoblast Differentiation....Pages 235-250
Production and Putative Roles of Inhibins and Corticotropin-Releasing Factor in Human Placenta and Decidua....Pages 251-260
The Influence of the Uterine Environment on Human Preimplantation Development....Pages 261-271
Back Matter....Pages 273-284
....Pages 285-291