Ebook: Cytomegalovirus: Biology and Infection

Although there are a number of excellent current reviews on one or another aspect of cytomegalovirus, the last comprehensive treatment of this subject was that of Krech et al. (197la). In view of the amazing advances in the virological, epidemiologic, and clinical knowledge of cytomegaloviruses, an up-to-date book is needed. Such a work should cover many areas of expertise and a voluminous technical literature. Each area might have been reviewed and analyzed by workers more expert than myself. However, I have embarked on the entire venture alone in order to attain unity and continuity in this book, characteristics that are not easily achieved in the more popular multiauthored works. I have tried to review the Iiterature and provide a critical summary for each area discussed. To do this, I provide as much of the primary data of the relevant works as needed and not just the qualitative conclusions. Inevitably, the flow of the narrative may be interrupted by dry facts and figures. However, such information is essential to make this a meaningful reference work. But for those not interested in such details, I have provided at what I hope are crucial points critiques and summaries. This book is not an exhaustive review of all the literature. This is probably no Ionger possible or even desirable. By selection, however, one runs the risk of having missed or ignored important papers. I am keenly aware of this, and I wish to apologize for such oversight, if that is possible.

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Content:
Front Matter....Pages i-xix
History of Cytomegalovirus....Pages 1-6
Molecular Biology of Cytomegalovirus Replication....Pages 7-35
Gene Products of Cytomegalovirus and Their Immunologic Significance....Pages 37-56
Characteristics of Cytomegalovirus....Pages 57-73
Virological Diagnosis and Infections in Cells and Tissues....Pages 75-99
Serologic Tests for Cytomegalovirus Infections....Pages 101-126
Cell-Mediated Immunity to Cytomegalovirus Infection....Pages 127-143
Variants of Human Cytomegalovirus....Pages 145-153
Epidemiology of Cytomegalovirus Infection in Man....Pages 155-187
Pathology of Cytomegalovirus Infection....Pages 189-204
Congenital and Perinatal Human Cytomegalovirus Infections....Pages 205-227
Acquired Cytomegalovirus Infection in Immunocompetent Patients....Pages 229-247
Human Cytomegalovirus Infections in Immunosuppressed Patients....Pages 249-300
Treatment and Prevention of Cytomegalovirus Infections....Pages 301-317
Nonhuman Cytomegaloviruses....Pages 319-326
Murine Cytomegalovirus....Pages 327-353
Back Matter....Pages 355-440

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Content:
Front Matter....Pages i-xix
History of Cytomegalovirus....Pages 1-6
Molecular Biology of Cytomegalovirus Replication....Pages 7-35
Gene Products of Cytomegalovirus and Their Immunologic Significance....Pages 37-56
Characteristics of Cytomegalovirus....Pages 57-73
Virological Diagnosis and Infections in Cells and Tissues....Pages 75-99
Serologic Tests for Cytomegalovirus Infections....Pages 101-126
Cell-Mediated Immunity to Cytomegalovirus Infection....Pages 127-143
Variants of Human Cytomegalovirus....Pages 145-153
Epidemiology of Cytomegalovirus Infection in Man....Pages 155-187
Pathology of Cytomegalovirus Infection....Pages 189-204
Congenital and Perinatal Human Cytomegalovirus Infections....Pages 205-227
Acquired Cytomegalovirus Infection in Immunocompetent Patients....Pages 229-247
Human Cytomegalovirus Infections in Immunosuppressed Patients....Pages 249-300
Treatment and Prevention of Cytomegalovirus Infections....Pages 301-317
Nonhuman Cytomegaloviruses....Pages 319-326
Murine Cytomegalovirus....Pages 327-353
Back Matter....Pages 355-440
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