Ebook: Drugs of Abuse, Immunity, and Immunodeficiency

This volume is based on the program of the International Conference on Drugs of Abuse, Immunity and Immunodeficiency held in Clearwater Beach, Florida. It was sponsored by the University of South Florida College of Medicine with the support of the National Institute on Drug Abuse. During the past few decades, drugs of abuse, including marijuana, cocaine, opiates and alcohol, have been studied by biomedical scientists in terms of the systemic effects of the drugs as well as alterations in neurophysiology and the psychology. More recently, the scope of such investigations has been broadened to include alterations within the immune system, and the influence of altered immunity on physiological and psychological consequences of drug abuse. In this regard, participants in the Clearwater Beach conference provided new information concern­ ing both basic and clinical aspects of drugs of abuse and immunity, especially immunodeficiency. Advances have been made in recent years in understanding the nature and mechanisms regulating the immune response and the mechanisms by which drugs may influence immune responses. In particular, the emergence of psychoneuroimmunology as a new discipline has heightened interest in immune responses influenced by psychoactive drugs. This has resulted in interdisciplinary investigations involving clinical and basic scientists including microbiologists, immu­ nologists, physiologists, psychiatrists, oncologists and others. The recreational use of the above mentioned drugs by large numbers of individuals has aroused serious concern about the consequences of this activity.

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Content:
Front Matter....Pages i-xii
Immunopharmacology and Immunotoxicology....Pages 1-11
Neuroimmunopharmacologic Effects of Drugs of Abuse....Pages 13-23
Altered Serum Immunoglobulin Concentration in Chronic Marijuana Smokers....Pages 25-32
Advanced Malignancy in the Young Marijuana Smoker....Pages 33-46
Effects of Marijuana on Human Natural Killer Cell Activity....Pages 47-56
Adverse Effect of ?9-Tetrahydrocannabinol on Human Neutrophil Function....Pages 57-62
Effect of Stereospecific Cannabinoids on the Immune System....Pages 63-70
Drugs of Abuse and Experimental Autoimmune Diseases....Pages 71-80
Effects of Marijuana on Macrophage Function....Pages 81-92
Cannabinoid Induced Changes in Eicosanoid Synthesis by Mouse Peritoneal Cells....Pages 93-105
Suppression of T Lymphocyte Subpopulations by THC....Pages 107-112
Drugs of Abuse and Infections....Pages 113-117
Combined Immunosuppressive Activities of Delta-9-Tetrahydrocannabinol and Murine Retrovirus....Pages 119-125
Effects of Cocaine and Other Drugs of Abuse on Immune Function....Pages 127-133
Cocaine Effects on Cultured Lymphocytes....Pages 135-141
Opiates, Human Peripheral Blood Mononuclear Cells, and HIV....Pages 143-150
Opiates as Immunosuppressive and Genotoxic Agents....Pages 151-158
The Effect of Morphine and Dago on the Proliferative Response of Murine Splenocytes....Pages 159-170
Endorphin Peptides Enhance Mitogen-Induced T Cell Proliferation Which has been Suppressed by Prostaglandins....Pages 171-178
Biochemical Characterization of Naloxone-Resistant Receptors for B-Endorphin on a Human Mononuclear Cell Line (U937) and Murine Splenocytes....Pages 179-187
Effects of Morphine Addiction on the Pathogenesis of Murine Toxoplasmosis....Pages 189-201
Immunodeficiency Associated with Ethanol Abuse....Pages 203-209
Effect of Prenatal Alcohol Exposure on Lymphocyte Populations in Mice....Pages 211-214
The Effects of Ethanol, Tumor Necrosis Factor, and Granulocyte Colony-Stimulating Factor on Lung Antibacterial Defenses....Pages 215-222
Immunosuppressive Effect of Alcohol on Hepatic Parenchymal and Nonparenchymal Cell Functions Following Endotoxin....Pages 223-227
Inhaled Isobutyl Nitrite Impairs T Cell Reactivity....Pages 229-236
Isoprenoid Formation and Cell-Mediated Immunological Functions....Pages 237-244
The Effects of Canthaxanthin on JB/MS Melanoma Growth During Retroviral Pathogenesis Induced by LP-BM5 Murine Leukemia Virus....Pages 245-253
Interaction of Delta-9-Tetrahydrocannabinol with Herpesviruses and Cultural Conditions Associated with Drug-Induced Anti-Cellular Effects....Pages 255-264
Back Matter....Pages 265-268
....Pages 269-278