Ebook: Novel Calcium-Binding Proteins: Fundamentals and Clinical Implications

A wide variety of hormones, neurotransmitters and growth factors exert their cellular effects by reacting first with membrane receptors resulting in an increase of intracellular calcium and the cellular response. The calcium signal in the cell is mediated by the high-affinity calcium binding proteins (characterized by the EF-hand structural element), and by the calcium and phospholipid dependent proteins. Many of these have been discovered most recently. Their purification, distribution, protein and gene structures as well as their physiological roles are discussed. The book is of interest to biochemists and molecular biologists as well as to clinicians and the pharmaceutical industry who can apply the results in this field.

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A wide variety of hormones, neurotransmitters and growth factors exert their cellular effects by reacting first with membrane receptors resulting in an increase of intracellular calcium and the cellular response. The calcium signal in the cell is mediated by the high-affinity calcium binding proteins (characterized by the EF-hand structural element), and by the calcium and phospholipid dependent proteins. Many of these have been discovered most recently. Their purification, distribution, protein and gene structures as well as their physiological roles are discussed. The book is of interest to biochemists and molecular biologists as well as to clinicians and the pharmaceutical industry who can apply the results in this field.

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A wide variety of hormones, neurotransmitters and growth factors exert their cellular effects by reacting first with membrane receptors resulting in an increase of intracellular calcium and the cellular response. The calcium signal in the cell is mediated by the high-affinity calcium binding proteins (characterized by the EF-hand structural element), and by the calcium and phospholipid dependent proteins. Many of these have been discovered most recently. Their purification, distribution, protein and gene structures as well as their physiological roles are discussed. The book is of interest to biochemists and molecular biologists as well as to clinicians and the pharmaceutical industry who can apply the results in this field.
Content:
Front Matter....Pages I-5
Calcium-Binding Proteins: Past, Present and Future....Pages 7-12
Acknowledgments....Pages 13-13
Front Matter....Pages 15-15
The EF-Hand, Homologs and Analogs....Pages 17-37
Calcium-Binding Proteins of the EF-Hand-Type and of the Annexin Family: A Survey....Pages 39-49
Stains-All is a Dye that Probes the Conformational Features of Calcium Binding Proteins....Pages 51-61
Front Matter....Pages 63-63
The S-100 Protein Family: A Biochemical and Functional Overview....Pages 65-103
p9Ka, A Calcium-Ion-Binding Protein of Cultured Myoepithelial Cells....Pages 105-123
S-100-Related Proteins in Nerve Growth Factor-Induced Differentiation of PC12 Cells....Pages 125-137
p11, A Member of the S-100 Protein Family, is Associated with the Tyrosine Kinase Substrate p36 (Annexin II)....Pages 139-155
Calcyclin, from Gene to Protein....Pages 157-167
Cloning and Characterization of a cDNA Encoding a Highly Conserved Ca2+-Binding Protein, Identified by an Anti-Prolactin Receptor Antibody....Pages 169-190
The Calgranulins, Members of the S-100 Protein Family: Structural Features, Expression, and Possible Function....Pages 191-223
Distribution of the Calcium-Binding Proteins MRP-8 and MRP-14 in Normal and Pathological Conditions: Relation to the Cystic Fibrosis Antigen....Pages 225-236
Front Matter....Pages 237-247
Calretinin....Pages 249-249
Purification, Identification and Regional Localization of a Brain-Specific Calretinin-Like Calcium Binding Protein (Protein 10)....Pages 251-276
Nonmuscle ?-Actinin is an EF-Hand Protein....Pages 277-300
EF-Hands Calcium Binding Regulates the Thioredoxin Reductase/Thioredoxin Electron Transfer in Human Keratinocytes and Melanoma....Pages 301-320
Calcium-Binding Crystallins....Pages 321-337
Front Matter....Pages 339-360
Cloning and Sequencing of a New Calmodulin Related Calcium-Binding Protein Controlled by Cyclic AMP Dependent Phosphorylation in the Thyroid: Calcyphosine....Pages 361-374
A 22 kDa Calcium-Binding Protein, Sorcin, is Encoded by Amplified Genes in Multidrug-Resistant Cells....Pages 249-249
Front Matter....Pages 375-384
Coordination and Stability of Calcium-Binding Site: D-Galactose/D-Glucose-Binding Protein of Bacterial Active Transport and Chemotaxis System....Pages 385-399
Calcium-Binding Sites in Myeloperoxidase and Lactoperoxidase....Pages 401-401
Unique Ca2+-Binding Proteins in Metazoan Invertebrates....Pages 403-423
Spec Proteins: Calcium-Binding Proteins in the Embryonic Ectoderm of Sea Urchins....Pages 425-435
Front Matter....Pages 437-446
Putative Calcium-Binding Sites in Voltage-Gated Sodium and Calcium Channel ?1 Subunits....Pages 447-463
Alterations of Cellular Calcium Metabolism and Calcium Binding in Hypertension and Human Cardiac Hypertrophy....Pages 465-479
Front Matter....Pages 481-495
Diversity in the Annexin Family....Pages 497-503
Annexin I and its Biochemical Properties....Pages 505-510
The Anti-Inflammatory Activity of Human Recombinant Lipocortin 1....Pages 511-511
Back Matter....Pages 513-521
....Pages 523-532