Ebook: Anti-Idiotypic Vaccines

Vaccines have historically been considered to be the most cost-effective method for preventing communicable diseases. It was a vaccine~hat enabled global eradication of the dreaded disease smallpox. Mass immunization of children forms the anchor of the strategy of the World Health Organization (WHO) to attain "health for all" status by the year 2000. Vaccinology is undergoing a dimensional change with the advances that have taken place in immunology and genetic engineering. Vaccines that confer short or inadequate immunity or that have side effects are being replaced by better vaccines. New vaccines are being developed for a variety of maladies. Monoclonal antibodies and T cell clones have been employed to delineate the immunodeterminants on microbes, an approach elegantly complemented by computer graphics and molecular imaging techniques. Possibilities have opened for obtaining hitherto scarce antigens of parasites by the DNA recombinant route. Better appreciation of the idiotypic network has aroused research on anti-idiotypic vaccines. Solid-phase synthesis of peptides is leading to an array of synthetic vaccines, an approach that is expected to attain its full potential once the sequences activating suppressor cells are discovered and the rules for presentation of antigens to T and B cells are better worked out. A new breed of vaccines is on the horizon that seeks to control fertility.

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With Anti-Idiotypic Vaccines, the third volume in the new series "Progress in Vaccinology", Pierre-Andre Cazenave has assembled ten invited critical reviews by leading researchers in the fields of immunology and vaccinology. Since the network hypothesis was first elaborated by Niels Jerne, the concept of internal images and idiotype has stimulated considerable research and discussion, in particular the design of more efficient vaccination methods than traditional procedures provide. In this volume both fundamental aspects and practical applications of idiotype for vaccines are considered. Anti-Idiotypic Vaccines first establishes a conceptual framework, then considers animal models for specific idiotypic reagents, including their role as potential tumor and viral vaccines. Other topics in- clude: relevance of idiotypic vaccines to carbohydrate antigens; implications of human VH gene family polymorphism for idiotype; novel approaches to immunoprophylaxis against parasites; and structural and functional manipulation of anti-idiotypes by antibody engineering. This book will be valuable to professional immunologists and vaccinologists, as well as to other molecular and cell biologists studying the immune system.

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With Anti-Idiotypic Vaccines, the third volume in the new series "Progress in Vaccinology", Pierre-Andre Cazenave has assembled ten invited critical reviews by leading researchers in the fields of immunology and vaccinology. Since the network hypothesis was first elaborated by Niels Jerne, the concept of internal images and idiotype has stimulated considerable research and discussion, in particular the design of more efficient vaccination methods than traditional procedures provide. In this volume both fundamental aspects and practical applications of idiotype for vaccines are considered. Anti-Idiotypic Vaccines first establishes a conceptual framework, then considers animal models for specific idiotypic reagents, including their role as potential tumor and viral vaccines. Other topics in- clude: relevance of idiotypic vaccines to carbohydrate antigens; implications of human VH gene family polymorphism for idiotype; novel approaches to immunoprophylaxis against parasites; and structural and functional manipulation of anti-idiotypes by antibody engineering. This book will be valuable to professional immunologists and vaccinologists, as well as to other molecular and cell biologists studying the immune system.
Content:
Front Matter....Pages i-xii
Some Thoughts on the Future of Idiotypic Vaccines....Pages 1-7
Stimulation of Lymphocytic Clones by Anti-Idiotypic Antibodies: Basis for Development of Idiotypic Vaccines....Pages 8-21
Small Human VH Gene Families Show Remarkably Little Polymorphism....Pages 22-30
Anti-Idiotypic Vaccines for Carbohydrate Antigens....Pages 31-41
Characterization of Idiotypic Reagents as Antigen Surrogates of a Human Tumor-Associated Antigen....Pages 42-54
Anti-Idiotypic Tumor Vaccines....Pages 55-72
Anti-Idiotypic Antibodies as Potential Viral Vaccines....Pages 73-91
Utilization of Anti-Idiotypic Antibodies as Molecular Probes of Virus—Receptor Interaction....Pages 92-106
Anti-Idiotypic Antibodies: An Alternative Approach to Immunoprophylaxis Against Parasites....Pages 107-122
Idiotype Vaccines by Antibody Engineering: Structural and Functional Considerations....Pages 123-137
Back Matter....Pages 138-139

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With Anti-Idiotypic Vaccines, the third volume in the new series "Progress in Vaccinology", Pierre-Andre Cazenave has assembled ten invited critical reviews by leading researchers in the fields of immunology and vaccinology. Since the network hypothesis was first elaborated by Niels Jerne, the concept of internal images and idiotype has stimulated considerable research and discussion, in particular the design of more efficient vaccination methods than traditional procedures provide. In this volume both fundamental aspects and practical applications of idiotype for vaccines are considered. Anti-Idiotypic Vaccines first establishes a conceptual framework, then considers animal models for specific idiotypic reagents, including their role as potential tumor and viral vaccines. Other topics in- clude: relevance of idiotypic vaccines to carbohydrate antigens; implications of human VH gene family polymorphism for idiotype; novel approaches to immunoprophylaxis against parasites; and structural and functional manipulation of anti-idiotypes by antibody engineering. This book will be valuable to professional immunologists and vaccinologists, as well as to other molecular and cell biologists studying the immune system.
Content:
Front Matter....Pages i-xii
Some Thoughts on the Future of Idiotypic Vaccines....Pages 1-7
Stimulation of Lymphocytic Clones by Anti-Idiotypic Antibodies: Basis for Development of Idiotypic Vaccines....Pages 8-21
Small Human VH Gene Families Show Remarkably Little Polymorphism....Pages 22-30
Anti-Idiotypic Vaccines for Carbohydrate Antigens....Pages 31-41
Characterization of Idiotypic Reagents as Antigen Surrogates of a Human Tumor-Associated Antigen....Pages 42-54
Anti-Idiotypic Tumor Vaccines....Pages 55-72
Anti-Idiotypic Antibodies as Potential Viral Vaccines....Pages 73-91
Utilization of Anti-Idiotypic Antibodies as Molecular Probes of Virus—Receptor Interaction....Pages 92-106
Anti-Idiotypic Antibodies: An Alternative Approach to Immunoprophylaxis Against Parasites....Pages 107-122
Idiotype Vaccines by Antibody Engineering: Structural and Functional Considerations....Pages 123-137
Back Matter....Pages 138-139
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