Ebook: Neurobiology of Opioids

Dedicated to Professor Albert Herz, a leading investigator in opioid research, this book provides comprehensive information on the biology of exogenous and endogenous opioids. Contributions by experts in the field discuss recent advances and provide systematic, up-to-date reviews of the physiology and pharmacology of opioids, as well as on the cellular and molecular mechanisms underlying opioid actions. In recognition of the diverse methodologies now available to researchers, each chapter details the approaches used to address a specific issue and provides an in-depth analysis of the data obtained by these various experimental approaches. The clinical relevance of recent findings, as well as future directions, in opioid research are also discussed. This volume thus represents a timely and invaluable sourcebook for researchers, clinicians, and students interested in opioids and peptidergic systems.

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Dedicated to Professor Albert Herz, a leading investigator in opioid research, this book provides comprehensive information on the biology of exogenous and endogenous opioids. Contributions by experts in the field discuss recent advances and provide systematic, up-to-date reviews of the physiology and pharmacology of opioids, as well as on the cellular and molecular mechanisms underlying opioid actions. In recognition of the diverse methodologies now available to researchers, each chapter details the approaches used to address a specific issue and provides an in-depth analysis of the data obtained by these various experimental approaches. The clinical relevance of recent findings, as well as future directions, in opioid research are also discussed. This volume thus represents a timely and invaluable sourcebook for researchers, clinicians, and students interested in opioids and peptidergic systems.

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Dedicated to Professor Albert Herz, a leading investigator in opioid research, this book provides comprehensive information on the biology of exogenous and endogenous opioids. Contributions by experts in the field discuss recent advances and provide systematic, up-to-date reviews of the physiology and pharmacology of opioids, as well as on the cellular and molecular mechanisms underlying opioid actions. In recognition of the diverse methodologies now available to researchers, each chapter details the approaches used to address a specific issue and provides an in-depth analysis of the data obtained by these various experimental approaches. The clinical relevance of recent findings, as well as future directions, in opioid research are also discussed. This volume thus represents a timely and invaluable sourcebook for researchers, clinicians, and students interested in opioids and peptidergic systems.
Content:
Front Matter....Pages I-XXII
Front Matter....Pages 1-1
Opioid Receptor Subtypes: Past, Present and Future....Pages 3-9
Opioid Peptide Genes: Structure and Regulation....Pages 11-51
Distribution of Opioids in Brain and Peripheral Tissues....Pages 53-71
Front Matter....Pages 73-73
Multiple Opioid Receptors....Pages 75-88
Molecular Approaches to Isolating Opioid Receptors....Pages 89-100
Interactions Between Opioid Receptors and Guanine Nucleotide Regulatory Proteins in Intact Membranes: Studies in a Neurotumor Cell Line....Pages 101-120
Guanine Nucleotide-Binding Proteins and Their Coupling to Opioid Receptors....Pages 121-140
Opioid Receptors and Ion Channels....Pages 141-150
Cellular Signaling Mechanisms Regulating Opioid Peptide Gene Expression....Pages 151-165
Front Matter....Pages 167-167
Central Distribution of Opioid Receptors: A Cross-Species Comparison of the Multiple Opioid Systems of the Basal Ganglia....Pages 169-183
Modulation of Central Opioid Receptors....Pages 185-197
The Control of Hypothalamic Opioid Peptide Release....Pages 199-211
Modulation of Catecholamine Release in the Central Nervous System by Multiple Opioid Receptors....Pages 213-225
Front Matter....Pages 227-227
Adaptation of Opioid Systems to Stress....Pages 229-243
Endogenous Opioid Systems in the Control of Pain....Pages 245-260
Opioid Interactions with Other Neuropeptides in the Spinal Cord: Relevance to Nociception....Pages 261-271
Opioid Analgesia at Peripheral Sites....Pages 273-285
Regulation of Intestinal Motility by Peripheral Opioids: Facts and Hypotheses....Pages 287-299
A Neuroendocrine Perspective of Sex and Drugs....Pages 301-330
Motivational Effects of Opioids: Neurochemical and Neuroanatomical Substrates....Pages 331-350
Front Matter....Pages 227-227
Psychotomimetic Effects of Opioids....Pages 351-362
Psychiatric Aspects of Opioid Research....Pages 363-367
Functional Correlates of Opioid Receptor Activation as Measured by Local Cerebral Glucose Utilization....Pages 369-384
Front Matter....Pages 385-385
Tolerance and Physical Dependence: Physiological Manifestations of Chronic Exposure to Opioids....Pages 387-405
Aspects of Opioid Tolerance and Dependence in Peripheral Nerve Tissues....Pages 407-415
Overview of Opioid Tolerance and Physical Dependence....Pages 417-439
Front Matter....Pages 441-441
Some Thoughts on the Present Status and Future of Opioid Research....Pages 443-446
Back Matter....Pages 447-456

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Dedicated to Professor Albert Herz, a leading investigator in opioid research, this book provides comprehensive information on the biology of exogenous and endogenous opioids. Contributions by experts in the field discuss recent advances and provide systematic, up-to-date reviews of the physiology and pharmacology of opioids, as well as on the cellular and molecular mechanisms underlying opioid actions. In recognition of the diverse methodologies now available to researchers, each chapter details the approaches used to address a specific issue and provides an in-depth analysis of the data obtained by these various experimental approaches. The clinical relevance of recent findings, as well as future directions, in opioid research are also discussed. This volume thus represents a timely and invaluable sourcebook for researchers, clinicians, and students interested in opioids and peptidergic systems.
Content:
Front Matter....Pages I-XXII
Front Matter....Pages 1-1
Opioid Receptor Subtypes: Past, Present and Future....Pages 3-9
Opioid Peptide Genes: Structure and Regulation....Pages 11-51
Distribution of Opioids in Brain and Peripheral Tissues....Pages 53-71
Front Matter....Pages 73-73
Multiple Opioid Receptors....Pages 75-88
Molecular Approaches to Isolating Opioid Receptors....Pages 89-100
Interactions Between Opioid Receptors and Guanine Nucleotide Regulatory Proteins in Intact Membranes: Studies in a Neurotumor Cell Line....Pages 101-120
Guanine Nucleotide-Binding Proteins and Their Coupling to Opioid Receptors....Pages 121-140
Opioid Receptors and Ion Channels....Pages 141-150
Cellular Signaling Mechanisms Regulating Opioid Peptide Gene Expression....Pages 151-165
Front Matter....Pages 167-167
Central Distribution of Opioid Receptors: A Cross-Species Comparison of the Multiple Opioid Systems of the Basal Ganglia....Pages 169-183
Modulation of Central Opioid Receptors....Pages 185-197
The Control of Hypothalamic Opioid Peptide Release....Pages 199-211
Modulation of Catecholamine Release in the Central Nervous System by Multiple Opioid Receptors....Pages 213-225
Front Matter....Pages 227-227
Adaptation of Opioid Systems to Stress....Pages 229-243
Endogenous Opioid Systems in the Control of Pain....Pages 245-260
Opioid Interactions with Other Neuropeptides in the Spinal Cord: Relevance to Nociception....Pages 261-271
Opioid Analgesia at Peripheral Sites....Pages 273-285
Regulation of Intestinal Motility by Peripheral Opioids: Facts and Hypotheses....Pages 287-299
A Neuroendocrine Perspective of Sex and Drugs....Pages 301-330
Motivational Effects of Opioids: Neurochemical and Neuroanatomical Substrates....Pages 331-350
Front Matter....Pages 227-227
Psychotomimetic Effects of Opioids....Pages 351-362
Psychiatric Aspects of Opioid Research....Pages 363-367
Functional Correlates of Opioid Receptor Activation as Measured by Local Cerebral Glucose Utilization....Pages 369-384
Front Matter....Pages 385-385
Tolerance and Physical Dependence: Physiological Manifestations of Chronic Exposure to Opioids....Pages 387-405
Aspects of Opioid Tolerance and Dependence in Peripheral Nerve Tissues....Pages 407-415
Overview of Opioid Tolerance and Physical Dependence....Pages 417-439
Front Matter....Pages 441-441
Some Thoughts on the Present Status and Future of Opioid Research....Pages 443-446
Back Matter....Pages 447-456
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