Ebook: Immunobiology and Prophylaxis of Human Herpesvirus Infections

No one whose opinion deserves a moment's consideration can doubt that most of the great positive evils of the world are in themselves removable, and will, if human affairs continue to improve, be in the end reduced to narrow limits. J. S. Mill, Utilitarianism, II, 1863 Mill was not writing about herpesviruses, but had he known them as we do, he would have included them among the great positive evils of the world. They cause disease and premature death, and are very costly to our society. There is no loftier aim than to cure or prevent human infections with these viruses. The objective of much of the current research on herpesviruses is directed toward an understanding of the molecular mechanisms involved in initiation of infection, establish­ ment and termination of latent state, virus multiplication, and the destruction of cells which ultimately is the basis of the diseases caused by these viruses. At no time during the past 80 years, since members of the herpesvirus family were first discovered, has there been so much progress in our understanding of the biology of these viruses as in the past few years. Along with the development of a greater understanding of the molecular biol­ ogy of the well-known herpesviruses we have witnessed the isolation of new human herpes­ viruses.

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Content:
Front Matter....Pages i-ix
Cellular and Growth-Factor Requirements for the Replication of Human Herpesvirus 6 in Primary Lymphocyte Cultures....Pages 1-8
Genomic Heterogeneity of Human Herpesvirus 6 Isolates....Pages 9-18
Replication of Human Herpesvirus 6 (HHV-6): Morphological Aspects....Pages 19-28
Exanthem Subitum and Human Herpesvirus 6 (HHV-6) Infection....Pages 29-37
Viral Pathology of Human Herpesvirus 6 Infection....Pages 39-47
A Live Varicella Vaccine....Pages 49-58
Differentiation between the Oka Varicella Vaccine Virus and American Wild-Type Varicella-Zoster Virus (VZV)....Pages 59-69
The T-Lymphocyte Response to Varicella-Zoster Viral Proteins....Pages 71-81
A Possible Role for Glycoprotein gpV in the Pathogenesis of Varicella-Zoster Virus....Pages 83-91
Changes in the Epidemiology of Cytomegalovirus....Pages 93-104
Antiviral Activities of a Human Monoclonal Antibody against Human Cytomegalovirus....Pages 105-113
On the Biology of Epstein-Barr Virus Persistence: A Reappraisal....Pages 115-124
Epstein-Barr Virus, Burkitt’s Lymphoma, and an African Tumor Promoter....Pages 125-136
Regulation of Expression of the Glycoprotein Genes of Herpes Simplex Virus Type 1 (HSV-1)....Pages 137-146
Antigenic and Structural Properties of Mutants in Herpes Simplex Virus 1 Glycoprotein B....Pages 147-150
Yeast-derived Glycoprotein B-1 of Herpes Simplex Virus (HSV) as a Candidate for an HSV Vaccine....Pages 151-164
Herpes Simplex Virus Type 1 Infection in Mice with Severe Combined Immunodeficiency (SCID)....Pages 165-182
Transcripts Associated with Herpes Simplex Virus Latency....Pages 183-190
Pathogenesis and Latency of Herpes Simplex Virus Type 1 (HSV-1): An Ophthalmologist’s View of the Eye as a Model for the Study of the Virus-Host Relationship....Pages 191-197
Mechanisms of Restriction of Viral Gene Expression during Herpes Simplex Virus Latency....Pages 199-204
Detection of a Highly Conserved Region of Herpesviridae DNA by In Vitro Enzymatic Amplification: Application to the Detection of a New Human Herpesvirus....Pages 205-209
Prevalence of Specific Antibodies to Herpes Simplex Virus Type 2 as Revealed by an Enzyme-linked Immunoassay and Western Blot Analysis....Pages 211-217
Acyclovir: The Past Ten Years....Pages 219-229
Brovavir: Its Antiherpesviral Activity and Mode of Action....Pages 231-242
A Double-Blind Clinical Study in Patients with Herpes Zoster to Establish YN-72 (Brovavir) Dose....Pages 243-253
(S)-1-(3-Hydroxy-2-(phosphonylmethoxy)propyl)cytosine (HPMPC): A Potent Antiherpesvirus Agent....Pages 255-265
Whither Herpesviruses....Pages 267-275
Back Matter....Pages 277-283
....Pages 285-291