Ebook: Chemical Carcinogenesis and Mutagenesis II

I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin­ Madison. I immediately started to work with the carcinogenic aminoazo dyes un­ der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABETH CA VERT, in marriage and we soon commenced a joyous part­ nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi­ cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car­ cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re­ lated factors.

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This is the second of two handbook volumes which present a wide-ranging review of current knowledge in the areas of chemical carcinogenesis and mutagenesis. Whereas the first volume covers the theories of carcinogenesis, exposure to chemical carcinogens, in vivo and in vitro carcinogenesis, and reactions of carcinogens with DNA, this second volume concentrates on the relationships between mutagenesis and carcinogenesis, modifiers of chemical carcinogenesis, and oncogenes in tumour development. Both volumes are of broad interest to pharmacologists and toxicologists and appeal especially to graduate and post-graduate research workers. This may be the first work ever to cover the complete range of carcinogenesis, from epidemiology to the effects of oncogenes on cellular differentiation. Thus it provides specialists in particular areas of cancer research with up-to-date overviews of adjacent areas.

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This is the second of two handbook volumes which present a wide-ranging review of current knowledge in the areas of chemical carcinogenesis and mutagenesis. Whereas the first volume covers the theories of carcinogenesis, exposure to chemical carcinogens, in vivo and in vitro carcinogenesis, and reactions of carcinogens with DNA, this second volume concentrates on the relationships between mutagenesis and carcinogenesis, modifiers of chemical carcinogenesis, and oncogenes in tumour development. Both volumes are of broad interest to pharmacologists and toxicologists and appeal especially to graduate and post-graduate research workers. This may be the first work ever to cover the complete range of carcinogenesis, from epidemiology to the effects of oncogenes on cellular differentiation. Thus it provides specialists in particular areas of cancer research with up-to-date overviews of adjacent areas.
Content:
Front Matter....Pages I-XXVI
Front Matter....Pages 1-1
Use of Mutations in Bacteria as Indicators of Carcinogenic Potential....Pages 3-26
Mammalian Cell Mutations....Pages 27-50
Mechanisms of Repair in Mammalian Cells....Pages 51-70
Cancer-Prone Human Disorders with Defects in DNA Repair....Pages 71-101
DNA Repair and Carcinogenesis by Alkylating Agents....Pages 103-131
Front Matter....Pages 133-133
Tumour Promotion: Biology and Molecular Mechanisms....Pages 135-157
Inhibition of Chemical Carcinogenesis....Pages 159-223
Genetic Susceptibility to Chemical Carcinogens....Pages 225-248
Interactive Effects Between Viruses and Chemical Carcinogens....Pages 249-268
Front Matter....Pages 269-269
Human Oncogenes....Pages 271-295
Recessive Oncogenes and Anti-Oncogenes....Pages 297-318
The Role of Oncogene Activation in Chemical Carcinogenesis....Pages 319-352
Growth Factors and Their Receptors....Pages 353-379
Signal Transduction in Proliferating Normal and Transformed Cells....Pages 381-401
Effect of Oncogenes on Cell Differentiation....Pages 403-438
Back Matter....Pages 439-467

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This is the second of two handbook volumes which present a wide-ranging review of current knowledge in the areas of chemical carcinogenesis and mutagenesis. Whereas the first volume covers the theories of carcinogenesis, exposure to chemical carcinogens, in vivo and in vitro carcinogenesis, and reactions of carcinogens with DNA, this second volume concentrates on the relationships between mutagenesis and carcinogenesis, modifiers of chemical carcinogenesis, and oncogenes in tumour development. Both volumes are of broad interest to pharmacologists and toxicologists and appeal especially to graduate and post-graduate research workers. This may be the first work ever to cover the complete range of carcinogenesis, from epidemiology to the effects of oncogenes on cellular differentiation. Thus it provides specialists in particular areas of cancer research with up-to-date overviews of adjacent areas.
Content:
Front Matter....Pages I-XXVI
Front Matter....Pages 1-1
Use of Mutations in Bacteria as Indicators of Carcinogenic Potential....Pages 3-26
Mammalian Cell Mutations....Pages 27-50
Mechanisms of Repair in Mammalian Cells....Pages 51-70
Cancer-Prone Human Disorders with Defects in DNA Repair....Pages 71-101
DNA Repair and Carcinogenesis by Alkylating Agents....Pages 103-131
Front Matter....Pages 133-133
Tumour Promotion: Biology and Molecular Mechanisms....Pages 135-157
Inhibition of Chemical Carcinogenesis....Pages 159-223
Genetic Susceptibility to Chemical Carcinogens....Pages 225-248
Interactive Effects Between Viruses and Chemical Carcinogens....Pages 249-268
Front Matter....Pages 269-269
Human Oncogenes....Pages 271-295
Recessive Oncogenes and Anti-Oncogenes....Pages 297-318
The Role of Oncogene Activation in Chemical Carcinogenesis....Pages 319-352
Growth Factors and Their Receptors....Pages 353-379
Signal Transduction in Proliferating Normal and Transformed Cells....Pages 381-401
Effect of Oncogenes on Cell Differentiation....Pages 403-438
Back Matter....Pages 439-467
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