Ebook: Chemical Carcinogenesis and Mutagenesis I
- Tags: Pharmacology/Toxicology, Biochemistry general, Oncology, Pharmacy
- Series: Handbook of Experimental Pharmacology 94 / 1
- Year: 1990
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin Madison. I immediately started to work with the carcinogenic aminoazo dyes un der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABE1H CAVERT, in marriage and we soon commenced a joyous part nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re lated factors.
Content:
Front Matter....Pages I-XXVIII
Front Matter....Pages 1-1
Mechanisms of Chemical Carcinogenesis: Theoretical and Experimental Bases....Pages 3-29
Front Matter....Pages 31-31
Environmental Carcinogens....Pages 33-61
Advances in Tobacco Carcinogenesis....Pages 63-102
Occupational Carcinogens....Pages 103-151
Therapeutic Agents as Potential Carcinogens....Pages 153-175
Front Matter....Pages 177-177
In Vivo Testing for Carcinogenicity....Pages 179-209
Transformation of Cells in Culture....Pages 211-264
Front Matter....Pages 265-265
Metabolic Activation and DNA Adducts of Aromatic Amines and Nitroaromatic Hydrocarbons....Pages 267-325
Polycyclic Aromatic Hydrocarbons: Metabolism, Activation and Tumour Initiation....Pages 327-372
Interactions of Fungal and Plant Toxins with DNA: Aflatoxins, Sterigmatocystin, Safrole, Cycasin, and Pyrrolizidine Alkaloids....Pages 373-407
N-Nitroso Compounds....Pages 409-469
Heterocyclic-Amine Mutagens/Carcinogens in Foods....Pages 471-502
Modern Methods of DNA Adduct Determination....Pages 503-546
Biological Consequences of Reactions with DNA: Role of Specific Lesions....Pages 547-571
Back Matter....Pages 573-604
Content:
Front Matter....Pages I-XXVIII
Front Matter....Pages 1-1
Mechanisms of Chemical Carcinogenesis: Theoretical and Experimental Bases....Pages 3-29
Front Matter....Pages 31-31
Environmental Carcinogens....Pages 33-61
Advances in Tobacco Carcinogenesis....Pages 63-102
Occupational Carcinogens....Pages 103-151
Therapeutic Agents as Potential Carcinogens....Pages 153-175
Front Matter....Pages 177-177
In Vivo Testing for Carcinogenicity....Pages 179-209
Transformation of Cells in Culture....Pages 211-264
Front Matter....Pages 265-265
Metabolic Activation and DNA Adducts of Aromatic Amines and Nitroaromatic Hydrocarbons....Pages 267-325
Polycyclic Aromatic Hydrocarbons: Metabolism, Activation and Tumour Initiation....Pages 327-372
Interactions of Fungal and Plant Toxins with DNA: Aflatoxins, Sterigmatocystin, Safrole, Cycasin, and Pyrrolizidine Alkaloids....Pages 373-407
N-Nitroso Compounds....Pages 409-469
Heterocyclic-Amine Mutagens/Carcinogens in Foods....Pages 471-502
Modern Methods of DNA Adduct Determination....Pages 503-546
Biological Consequences of Reactions with DNA: Role of Specific Lesions....Pages 547-571
Back Matter....Pages 573-604
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