Ebook: Leukocyte Adhesion Molecules

Leukocyte adhesion molecules promise to be highly effective as antigens in the antibody-directed leucocyte elimination treatment prior to grafting or in cases of acute and chronic inflammatory disease. This comprehensive review of contemporary research provides thorough discussions of the structure of these molecules, their in vitro function, and the role that they play in vivo as evidenced by results shown in inflammatory models where antibodies against these molecules are given to inhibit their function. The blend of basic science and clinical applications provides clear evidence of the biological relevance of cell-cell interactions and the many potential clinical dividends afforded by understanding the molecular basis of cell adhesion.

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Leukocyte adhesion molecules promise to be highly effective as antigens in the antibody-directed leucocyte elimination treatment prior to grafting or in cases of acute and chronic inflammatory disease. This comprehensive review of contemporary research provides thorough discussions of the structure of these molecules, their in vitro function, and the role that they play in vivo as evidenced by results shown in inflammatory models where antibodies against these molecules are given to inhibit their function. The blend of basic science and clinical applications provides clear evidence of the biological relevance of cell-cell interactions and the many potential clinical dividends afforded by understanding the molecular basis of cell adhesion.

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Leukocyte adhesion molecules promise to be highly effective as antigens in the antibody-directed leucocyte elimination treatment prior to grafting or in cases of acute and chronic inflammatory disease. This comprehensive review of contemporary research provides thorough discussions of the structure of these molecules, their in vitro function, and the role that they play in vivo as evidenced by results shown in inflammatory models where antibodies against these molecules are given to inhibit their function. The blend of basic science and clinical applications provides clear evidence of the biological relevance of cell-cell interactions and the many potential clinical dividends afforded by understanding the molecular basis of cell adhesion.
Content:
Front Matter....Pages i-xv
Introduction....Pages 1-3
Front Matter....Pages 5-5
Leukocyte Integrins....Pages 7-43
Structure and Functions for the Adhesion Receptors VLA-2 and VLA-4: Comparisons to other Members of the Integrin Superfamily....Pages 44-57
Fibronectin Receptor Expression on Thymocytes....Pages 58-71
Mechanism Regulating Recruitment of CD11b/CD18 to the Cell Surface is Distinct From That Which Induces Adhesion in Homotypic Neutrophil Aggregation....Pages 72-83
Front Matter....Pages 85-85
Mechanisms of Neutrophil Emigration....Pages 87-94
Leukocyte Adhesion Deficiency as a Model for the Study of the Functional Role of LFA-1....Pages 95-100
Role of Cellular Adhesion in Inflammatory Cutaneous Disorders....Pages 101-105
Characterization of a New Mobilizable Mac-1 (CD11b/CD18) Pool That Co-Localizes with Gelatinase in Human Neutrophils....Pages 106-124
Anti-Inflammatory Properties of Monoclonal Anti-Mo1 (CD11b/CD18) Antibodies In Vitro and In Vivo....Pages 125-137
CDw18 Dependent Adhesion of Leukocytes to Endothelium and Its Relevance for Cardiac Reperfusion....Pages 138-148
Role of Anti-Adhesion Monoclonal Antibodies in Rabbit Lung Inflammation....Pages 149-155
Front Matter....Pages 157-157
The Role of LFA-1 and Related Antigens in Adhesion-Mediated Functions of Human Monocytes....Pages 159-169
Role of ICAM-1 in the Adherence of Human Neutrophils to Human Endothelial Cells In Vitro....Pages 170-189
Specificity and Regulation of CD18-Dependent Adhesions....Pages 190-207
CD18 Dependence of Primate Eosinophil Adherence In Vitro....Pages 208-214
Identification and Characterization of Endothelial-Leukocyte Adhesion Molecule 1....Pages 215-223
Front Matter....Pages 225-225
Homing Receptors in Lymphocyte, Neutrophil, and Monocyte Interaction with Endothelial Cells....Pages 227-235
Antigen-Independent Adhesion: A Critical Process in Human Cytotoxic T Cell Recognition....Pages 236-243
Inhibition of Human Mixed Lymphocyte Reactions by Monoclonal Antibodies to Intercellular Adhesion Molecule-1 (ICAM-1)....Pages 244-253
Front Matter....Pages 225-225
Lymphocyte Function-Associated Antigen-1 (LFA-1) Is a Signaling Molecule for Human T Lymphocytes....Pages 254-264
Involvement of Lymphocyte Function-Associated Antigen-1 and Intercellular Adhesion Molecule-1 in Monocyte and T-Cell Antigen-Specific Interactions....Pages 265-273
Immunosuppression of Cynomolgus Recipients of Renal Allografts by R6.5, a Monoclonal Antibody to Intercellular Adhesion Molecule-1....Pages 274-281
Back Matter....Pages 283-287

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Leukocyte adhesion molecules promise to be highly effective as antigens in the antibody-directed leucocyte elimination treatment prior to grafting or in cases of acute and chronic inflammatory disease. This comprehensive review of contemporary research provides thorough discussions of the structure of these molecules, their in vitro function, and the role that they play in vivo as evidenced by results shown in inflammatory models where antibodies against these molecules are given to inhibit their function. The blend of basic science and clinical applications provides clear evidence of the biological relevance of cell-cell interactions and the many potential clinical dividends afforded by understanding the molecular basis of cell adhesion.
Content:
Front Matter....Pages i-xv
Introduction....Pages 1-3
Front Matter....Pages 5-5
Leukocyte Integrins....Pages 7-43
Structure and Functions for the Adhesion Receptors VLA-2 and VLA-4: Comparisons to other Members of the Integrin Superfamily....Pages 44-57
Fibronectin Receptor Expression on Thymocytes....Pages 58-71
Mechanism Regulating Recruitment of CD11b/CD18 to the Cell Surface is Distinct From That Which Induces Adhesion in Homotypic Neutrophil Aggregation....Pages 72-83
Front Matter....Pages 85-85
Mechanisms of Neutrophil Emigration....Pages 87-94
Leukocyte Adhesion Deficiency as a Model for the Study of the Functional Role of LFA-1....Pages 95-100
Role of Cellular Adhesion in Inflammatory Cutaneous Disorders....Pages 101-105
Characterization of a New Mobilizable Mac-1 (CD11b/CD18) Pool That Co-Localizes with Gelatinase in Human Neutrophils....Pages 106-124
Anti-Inflammatory Properties of Monoclonal Anti-Mo1 (CD11b/CD18) Antibodies In Vitro and In Vivo....Pages 125-137
CDw18 Dependent Adhesion of Leukocytes to Endothelium and Its Relevance for Cardiac Reperfusion....Pages 138-148
Role of Anti-Adhesion Monoclonal Antibodies in Rabbit Lung Inflammation....Pages 149-155
Front Matter....Pages 157-157
The Role of LFA-1 and Related Antigens in Adhesion-Mediated Functions of Human Monocytes....Pages 159-169
Role of ICAM-1 in the Adherence of Human Neutrophils to Human Endothelial Cells In Vitro....Pages 170-189
Specificity and Regulation of CD18-Dependent Adhesions....Pages 190-207
CD18 Dependence of Primate Eosinophil Adherence In Vitro....Pages 208-214
Identification and Characterization of Endothelial-Leukocyte Adhesion Molecule 1....Pages 215-223
Front Matter....Pages 225-225
Homing Receptors in Lymphocyte, Neutrophil, and Monocyte Interaction with Endothelial Cells....Pages 227-235
Antigen-Independent Adhesion: A Critical Process in Human Cytotoxic T Cell Recognition....Pages 236-243
Inhibition of Human Mixed Lymphocyte Reactions by Monoclonal Antibodies to Intercellular Adhesion Molecule-1 (ICAM-1)....Pages 244-253
Front Matter....Pages 225-225
Lymphocyte Function-Associated Antigen-1 (LFA-1) Is a Signaling Molecule for Human T Lymphocytes....Pages 254-264
Involvement of Lymphocyte Function-Associated Antigen-1 and Intercellular Adhesion Molecule-1 in Monocyte and T-Cell Antigen-Specific Interactions....Pages 265-273
Immunosuppression of Cynomolgus Recipients of Renal Allografts by R6.5, a Monoclonal Antibody to Intercellular Adhesion Molecule-1....Pages 274-281
Back Matter....Pages 283-287
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