Ebook: Ivermectin and Abamectin

Ivermectin and abamectin, members of the avermectin family of compounds, were introduced to the market in the 1980's as a veterinary antiparasitic drug and agricultural pesticide, respectively. Their acceptance and commercial success have been remarkable; both are highly effective and in worldwide use. The efficacy of ivermectin in river blindness has expanded the interest in its use in human medicine. In response to the intense scientific and industrial interest in ivermectin and abamectin and the likelihood that they will be forerunners of an expanding family of drugs, this comprehensive monograph satisfies the need for a review and synthesis of current knowledge about the use of these substances in crop protection as well as in cattle, sheep, swine, horses, dogs, cats, birds, fish, reptiles, and in man. This overview presents chemical, biochemical, and microbiological data, as well as pharmacological, safety, and environmental aspects and covers practical use of the compounds as antiparasitic and pesticide agents, as well as the available safety data that have emerged from the clinical experience with human applications.

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Ivermectin and abamectin, members of the avermectin family of compounds, were introduced to the market in the 1980's as a veterinary antiparasitic drug and agricultural pesticide, respectively. Their acceptance and commercial success have been remarkable; both are highly effective and in worldwide use. The efficacy of ivermectin in river blindness has expanded the interest in its use in human medicine. In response to the intense scientific and industrial interest in ivermectin and abamectin and the likelihood that they will be forerunners of an expanding family of drugs, this comprehensive monograph satisfies the need for a review and synthesis of current knowledge about the use of these substances in crop protection as well as in cattle, sheep, swine, horses, dogs, cats, birds, fish, reptiles, and in man. This overview presents chemical, biochemical, and microbiological data, as well as pharmacological, safety, and environmental aspects and covers practical use of the compounds as antiparasitic and pesticide agents, as well as the available safety data that have emerged from the clinical experience with human applications.

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Ivermectin and abamectin, members of the avermectin family of compounds, were introduced to the market in the 1980's as a veterinary antiparasitic drug and agricultural pesticide, respectively. Their acceptance and commercial success have been remarkable; both are highly effective and in worldwide use. The efficacy of ivermectin in river blindness has expanded the interest in its use in human medicine. In response to the intense scientific and industrial interest in ivermectin and abamectin and the likelihood that they will be forerunners of an expanding family of drugs, this comprehensive monograph satisfies the need for a review and synthesis of current knowledge about the use of these substances in crop protection as well as in cattle, sheep, swine, horses, dogs, cats, birds, fish, reptiles, and in man. This overview presents chemical, biochemical, and microbiological data, as well as pharmacological, safety, and environmental aspects and covers practical use of the compounds as antiparasitic and pesticide agents, as well as the available safety data that have emerged from the clinical experience with human applications.
Content:
Front Matter....Pages i-xx
Chemistry....Pages 1-23
Isolation and Characterization of the Producing Organism....Pages 24-32
Fermentation Development and Process Improvement....Pages 33-54
Biosynthesis....Pages 55-72
Mode of Action of Ivermectin....Pages 73-88
Toxicology....Pages 89-112
Pharmacokinetics of Ivermectin in Animals and Humans....Pages 113-130
Metabolism and Tissue Residues....Pages 131-143
Chemical Assay for Ivermectin in Edible Tissues....Pages 144-148
Safety of Ivermectin in Target Animals....Pages 149-161
Environmental Aspects of Ivermectin Usage in Livestock: General Considerations....Pages 162-172
Environmental Aspects of Use of Ivermectin and Abamectin in Livestock: Effects on Cattle Dung Fauna....Pages 173-181
Environmental Aspects of Abamectin Use in Crop Protection....Pages 182-200
Worker Safety Aspects of Abamectin Use in Crop Protection....Pages 201-214
Use of Ivermectin in Cattle, Sheep, Goats, and Swine....Pages 215-229
Use of Abamectin in Cattle....Pages 230-233
Use of Ivermectin in Horses....Pages 234-244
Use of Ivermectin in Dogs and Cats....Pages 245-259
Use of Ivermectin in Laboratory and Exotic Mammals and in Birds, Fish, and Reptiles....Pages 260-286
Abamectin Use in Crop Protection....Pages 287-310
Back Matter....Pages 324-363
Use of Ivermectin in Humans....Pages 311-323

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Ivermectin and abamectin, members of the avermectin family of compounds, were introduced to the market in the 1980's as a veterinary antiparasitic drug and agricultural pesticide, respectively. Their acceptance and commercial success have been remarkable; both are highly effective and in worldwide use. The efficacy of ivermectin in river blindness has expanded the interest in its use in human medicine. In response to the intense scientific and industrial interest in ivermectin and abamectin and the likelihood that they will be forerunners of an expanding family of drugs, this comprehensive monograph satisfies the need for a review and synthesis of current knowledge about the use of these substances in crop protection as well as in cattle, sheep, swine, horses, dogs, cats, birds, fish, reptiles, and in man. This overview presents chemical, biochemical, and microbiological data, as well as pharmacological, safety, and environmental aspects and covers practical use of the compounds as antiparasitic and pesticide agents, as well as the available safety data that have emerged from the clinical experience with human applications.
Content:
Front Matter....Pages i-xx
Chemistry....Pages 1-23
Isolation and Characterization of the Producing Organism....Pages 24-32
Fermentation Development and Process Improvement....Pages 33-54
Biosynthesis....Pages 55-72
Mode of Action of Ivermectin....Pages 73-88
Toxicology....Pages 89-112
Pharmacokinetics of Ivermectin in Animals and Humans....Pages 113-130
Metabolism and Tissue Residues....Pages 131-143
Chemical Assay for Ivermectin in Edible Tissues....Pages 144-148
Safety of Ivermectin in Target Animals....Pages 149-161
Environmental Aspects of Ivermectin Usage in Livestock: General Considerations....Pages 162-172
Environmental Aspects of Use of Ivermectin and Abamectin in Livestock: Effects on Cattle Dung Fauna....Pages 173-181
Environmental Aspects of Abamectin Use in Crop Protection....Pages 182-200
Worker Safety Aspects of Abamectin Use in Crop Protection....Pages 201-214
Use of Ivermectin in Cattle, Sheep, Goats, and Swine....Pages 215-229
Use of Abamectin in Cattle....Pages 230-233
Use of Ivermectin in Horses....Pages 234-244
Use of Ivermectin in Dogs and Cats....Pages 245-259
Use of Ivermectin in Laboratory and Exotic Mammals and in Birds, Fish, and Reptiles....Pages 260-286
Abamectin Use in Crop Protection....Pages 287-310
Back Matter....Pages 324-363
Use of Ivermectin in Humans....Pages 311-323
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