Ebook: Gene Regulation by Steroid Hormones IV

The first Meadowbrook Symposium was held in 1978 and during the intervening ten years our knowledge concerning how steroid hormones function at the level of gene expression has advanced by leaps and bounds. In this volume, which sum­ marizes our fourth meeting, these advances are very evident. What seemed like science fiction ten years ago has become commonplace science. Who would have imagined that we could synthesize a nucleotide sequence that binds a specific steroid receptor and acts as a controlling element for gene expression? No one; but as is evident from the results reported in several chapters, this technique is yielding a wealth of information. Using these and other techniques it has become apparent that gene transcription is controlled by interactions between transacting factors and DNA recognition sequences (response elements). These transacting factors appear to be members of a large gene family that includes steroid hormone receptors, transcription factors, protooncogenes and homeobox proteins. Thus a great deal has been learned, but as usual, questions remain. Many of these questions are posed by the findings and observations found in several chapters in this volume. Non­ hormone binding forms of steroid receptors and their relevance to receptor down regulation, recycling and biological response remain a mystery. The quantitative relationship between receptor binding and biological response still presents agonizing problems. These and many other intriguing questions are discussed in this volume and set the stage for what should be a most rewarding time in endocrinology. Winter 1989 ARUN K.

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This volume summarizes the Fourth Meadowbrook Symposium held in October 1988. Exciting new findings are discussed in the following areas: The synthesis of a nucleotide sequence that binds a specific steroid receptor and acts as controlling element for gene expression; the control of gene transcription by the interaction between transacting factors and DNA recognition sequences; the membership of the transacting factors in a large gene family that includes also steroid hormone receptors, transcription factors, protooncogenes, and homeobox proteins. Other topics are receptor down regulation and quantitive relationships between receptor binding and biological response.

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This volume summarizes the Fourth Meadowbrook Symposium held in October 1988. Exciting new findings are discussed in the following areas: The synthesis of a nucleotide sequence that binds a specific steroid receptor and acts as controlling element for gene expression; the control of gene transcription by the interaction between transacting factors and DNA recognition sequences; the membership of the transacting factors in a large gene family that includes also steroid hormone receptors, transcription factors, protooncogenes, and homeobox proteins. Other topics are receptor down regulation and quantitive relationships between receptor binding and biological response.
Content:
Front Matter....Pages i-xi
Towards a Molecular Understanding of Steroid Binding to Glucocorticoid Receptors....Pages 1-22
Regulation of Glucocorticoid Receptor Protein and Gene Expression by Glucocorticoids....Pages 23-40
Modulation of Glucocorticoid-Induced Responses by Cyclic AMP in Lymphoid Cell Lines....Pages 41-61
Differential Regulation of Tyrosine Amino-Transferase by Glucocorticoids: Transcriptional and Post-Transcriptional Control....Pages 63-77
Steroid Response Elements. Definition of a Minimal Promoter and Interaction with Other Activating Sequences....Pages 78-89
GHF-1, a Tissue-Specific Transcription Factor, is a Homeobox Protein....Pages 90-109
Regulation of EGF Receptors and Nuclear Protooncogenes by Estrogen....Pages 110-132
Regulation of the Rat Insulin II Gene: cis- and trans-acting Factors....Pages 133-143
Thyroid Hormone Regulation of Rat Liver S14 Gene Expression....Pages 144-162
Hormonal and Developmental Regulation of Xenopus Egg Protein Genes....Pages 163-181
Inhibition of the Intracellular Transformation of Rat Ventral Prostate Androgen Receptor by 3?-Deoxyadenosine....Pages 182-198
Androgen Action in Rat Liver: Changes in Androgen Sensitivity During Maturation and Aging....Pages 199-212
Inhibition of Cell Proliferation by a Nuclear Type II Ligand: Methyl P-Hydroxyphenylactate....Pages 213-219
Promoter Specific Activating Domains of the Chicken Progesterone Receptor....Pages 220-233
Back Matter....Pages 235-239

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This volume summarizes the Fourth Meadowbrook Symposium held in October 1988. Exciting new findings are discussed in the following areas: The synthesis of a nucleotide sequence that binds a specific steroid receptor and acts as controlling element for gene expression; the control of gene transcription by the interaction between transacting factors and DNA recognition sequences; the membership of the transacting factors in a large gene family that includes also steroid hormone receptors, transcription factors, protooncogenes, and homeobox proteins. Other topics are receptor down regulation and quantitive relationships between receptor binding and biological response.
Content:
Front Matter....Pages i-xi
Towards a Molecular Understanding of Steroid Binding to Glucocorticoid Receptors....Pages 1-22
Regulation of Glucocorticoid Receptor Protein and Gene Expression by Glucocorticoids....Pages 23-40
Modulation of Glucocorticoid-Induced Responses by Cyclic AMP in Lymphoid Cell Lines....Pages 41-61
Differential Regulation of Tyrosine Amino-Transferase by Glucocorticoids: Transcriptional and Post-Transcriptional Control....Pages 63-77
Steroid Response Elements. Definition of a Minimal Promoter and Interaction with Other Activating Sequences....Pages 78-89
GHF-1, a Tissue-Specific Transcription Factor, is a Homeobox Protein....Pages 90-109
Regulation of EGF Receptors and Nuclear Protooncogenes by Estrogen....Pages 110-132
Regulation of the Rat Insulin II Gene: cis- and trans-acting Factors....Pages 133-143
Thyroid Hormone Regulation of Rat Liver S14 Gene Expression....Pages 144-162
Hormonal and Developmental Regulation of Xenopus Egg Protein Genes....Pages 163-181
Inhibition of the Intracellular Transformation of Rat Ventral Prostate Androgen Receptor by 3?-Deoxyadenosine....Pages 182-198
Androgen Action in Rat Liver: Changes in Androgen Sensitivity During Maturation and Aging....Pages 199-212
Inhibition of Cell Proliferation by a Nuclear Type II Ligand: Methyl P-Hydroxyphenylactate....Pages 213-219
Promoter Specific Activating Domains of the Chicken Progesterone Receptor....Pages 220-233
Back Matter....Pages 235-239
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