Ebook: Receptors, Membrane Transport and Signal Transduction
- Tags: Cell Biology, Biochemistry general, Pharmacology/Toxicology
- Series: NATO ASI Series 29
- Year: 1989
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
A NATO Advanced study Institute on "Receptors, Membrane Trans port and Signal Transduction", was held on the Island of Spet sai, Greece, from August 16-27, 1988, in order to consider re cent developments in membrane receptor research, membrane trans port and signal transduction mechanisms. These topics were put in the larger context of current knowledge on the structure and function of membranes; connections between different fields of research were established by in-depth dis cussions of energy transduction and transport mechanisms. The general principles of regulation by signal transduction and protein phosphorylation/dephosphorylation were presented in the context of specific cellular processes. Discussions included al so the role of protein tyrosine kinases which are structurally related to oncogene products and, therefore, implicated in va rious aspects of cell development and transformation. This book presents the content of the major lectures and a se lection of the most relevant posters presented during the course of the Institute. The book is intended to make the proceedings of the Institute accessible to a larger audience and to offer a comprehensive account of those topics on receptors, membrane transport and signal transduction that were discussed extensive ly during the course of the Institute. February 1989 The Editors CONTENTS I. G-PROTEINS, ADENYLATE CYCLASE AND PROTEIN PHOSPHORYLATION Selective regulation of G proteins by Cell surface receptors ......... .
This book summarizes developments in membrane receptor research, membrane transport and signal transduction mechanisms. The general principles of regulation by signal transduction and protein phosphorylation/dephosphorylation are presented in the context of specific cellular processes. This also includes the role of protein tyrosine kinases which are structurally related to oncogene products and, therefore, implicated in various aspects of cell development and transformation. All topics are placed in the larger context of the current knowledge on the structure and function of membranes; connections between different fields of research are established by in-depth discussions on energy transduction and transport mechanisms.
This book summarizes developments in membrane receptor research, membrane transport and signal transduction mechanisms. The general principles of regulation by signal transduction and protein phosphorylation/dephosphorylation are presented in the context of specific cellular processes. This also includes the role of protein tyrosine kinases which are structurally related to oncogene products and, therefore, implicated in various aspects of cell development and transformation. All topics are placed in the larger context of the current knowledge on the structure and function of membranes; connections between different fields of research are established by in-depth discussions on energy transduction and transport mechanisms.
Content:
Front Matter....Pages I-VIII
Selective Regulation of G Proteins by Cell Surface Receptors....Pages 1-24
Regulation of Adenylate Cyclase in Mammalian Cells and Saccharomyces Cerevisiae....Pages 25-37
Protein Kinases, Protein Phosphatases and the Regulation of Glycogen Metabolism....Pages 38-54
Phosphorylase Kinase and Protein Kinase C: Functional Similarities....Pages 55-66
The Use of Specific Antisera to Locate Functional Domains of Guanine Nucleotide Binding Proteins....Pages 67-75
Calcium Inhibits GTP-Binding Proteins in Squid Photoreceptors....Pages 76-84
Degradation of the Invasive Adenylate Cyclase Toxin of Bordetella Pertussis by the Eukaryotic Target Cell-Lysate....Pages 85-94
Identification and Characterization of Adenylate Cyclases in Various Tissues by Monoclonal Antibodies....Pages 95-101
The Role of G-Proteins in Exocytosis....Pages 102-109
Hydrophobic Interactions in the Calcium- and Phospholipid Dependent Activation of Protein Kinase C....Pages 110-116
Activation of Transducin by Aluminum or Beryllium Fluoride Complexes....Pages 117-126
Glutamate Receptors and Glutamatergic Synapses....Pages 127-146
Mechanisms of Glutamate Exocytosis from Isolated Nerve Terminals....Pages 147-161
Characteristics of the Epidermal Growth Factor Receptor....Pages 162-185
Three-Dimensional Structural Models for EGF and Insulin Receptor Interactions and Signal Transduction....Pages 186-195
Potentiation of Neurotransmitter Release Coincides with Potentiation of Phosphatidyl Inositol Turnover — A Possible In Vitro Model for Long Term Potentiation (LTP)....Pages 196-213
Purification and Localization of Kainate Binding Protein in Pigeon Cerebellum....Pages 214-222
The Norepinephrine Analog Meta-Iodo-Benzylguanidine (MIBG) as a Substrate for Mono(ADP-Ribosylation)....Pages 223-232
The Synaptic Vesicle Vesamicol (AH5183) Receptor Contains a Low Affinity Acetylcholine Binding Site....Pages 233-241
Purification of the D-2 Dopamine Receptor and Characterization of Its Signal Transduction Mechanism....Pages 242-250
Downregulation of M1 and M2 Muscarinic Receptor Subtypes in Y1 Mouse Adrenocarcinoma Cells....Pages 251-262
Uptake of Gaba and L-Glutamate Into Synaptic Vesicles....Pages 263-271
Deactivation of Laminin-Specific Cell-Surface Receptors Accompanies Immobilization of Myoblasts During Differentiation....Pages 272-281
Signal Transduction in Halobacteria....Pages 282-301
Control of Bacterial Growth by Membrane Processes....Pages 302-319
Carbonylcyanide-3-Chlorophenylhydrazone A Prototype Agent for the Selective Killing of Cells in Acidic Regions of Solid Tumours....Pages 320-328
Ca2+ and pH Interactions in Thrombin Stimulated Human Platelets....Pages 329-337
Structure-Function Relationships of the pCloDF13 Encoded BRP....Pages 338-343
Binding of A Bacillus Thuringiensis Delta Endotoxin to the Midgut of the Tobacco Hornworm (Manduca Sexta)....Pages 344-351
Functional Reconstitution of Photosynthetic Reaction Centre Complexes from Rhodopseudomonas Palustris....Pages 352-361
Na+/H+ Exchange In Cardiac Cells: Implications For Electrical And Mechanical Events During Intracellular pH Changes....Pages 362-371
Receptor-Mediated Inhibition of Reproductive Activity in a Schistosome-Infected Freshwater Snail....Pages 372-381
NMR Study of Gramicidin Cation Transport Across and Integration into a Lipid Membrane....Pages 382-387
Back Matter....Pages 389-390
This book summarizes developments in membrane receptor research, membrane transport and signal transduction mechanisms. The general principles of regulation by signal transduction and protein phosphorylation/dephosphorylation are presented in the context of specific cellular processes. This also includes the role of protein tyrosine kinases which are structurally related to oncogene products and, therefore, implicated in various aspects of cell development and transformation. All topics are placed in the larger context of the current knowledge on the structure and function of membranes; connections between different fields of research are established by in-depth discussions on energy transduction and transport mechanisms.
Content:
Front Matter....Pages I-VIII
Selective Regulation of G Proteins by Cell Surface Receptors....Pages 1-24
Regulation of Adenylate Cyclase in Mammalian Cells and Saccharomyces Cerevisiae....Pages 25-37
Protein Kinases, Protein Phosphatases and the Regulation of Glycogen Metabolism....Pages 38-54
Phosphorylase Kinase and Protein Kinase C: Functional Similarities....Pages 55-66
The Use of Specific Antisera to Locate Functional Domains of Guanine Nucleotide Binding Proteins....Pages 67-75
Calcium Inhibits GTP-Binding Proteins in Squid Photoreceptors....Pages 76-84
Degradation of the Invasive Adenylate Cyclase Toxin of Bordetella Pertussis by the Eukaryotic Target Cell-Lysate....Pages 85-94
Identification and Characterization of Adenylate Cyclases in Various Tissues by Monoclonal Antibodies....Pages 95-101
The Role of G-Proteins in Exocytosis....Pages 102-109
Hydrophobic Interactions in the Calcium- and Phospholipid Dependent Activation of Protein Kinase C....Pages 110-116
Activation of Transducin by Aluminum or Beryllium Fluoride Complexes....Pages 117-126
Glutamate Receptors and Glutamatergic Synapses....Pages 127-146
Mechanisms of Glutamate Exocytosis from Isolated Nerve Terminals....Pages 147-161
Characteristics of the Epidermal Growth Factor Receptor....Pages 162-185
Three-Dimensional Structural Models for EGF and Insulin Receptor Interactions and Signal Transduction....Pages 186-195
Potentiation of Neurotransmitter Release Coincides with Potentiation of Phosphatidyl Inositol Turnover — A Possible In Vitro Model for Long Term Potentiation (LTP)....Pages 196-213
Purification and Localization of Kainate Binding Protein in Pigeon Cerebellum....Pages 214-222
The Norepinephrine Analog Meta-Iodo-Benzylguanidine (MIBG) as a Substrate for Mono(ADP-Ribosylation)....Pages 223-232
The Synaptic Vesicle Vesamicol (AH5183) Receptor Contains a Low Affinity Acetylcholine Binding Site....Pages 233-241
Purification of the D-2 Dopamine Receptor and Characterization of Its Signal Transduction Mechanism....Pages 242-250
Downregulation of M1 and M2 Muscarinic Receptor Subtypes in Y1 Mouse Adrenocarcinoma Cells....Pages 251-262
Uptake of Gaba and L-Glutamate Into Synaptic Vesicles....Pages 263-271
Deactivation of Laminin-Specific Cell-Surface Receptors Accompanies Immobilization of Myoblasts During Differentiation....Pages 272-281
Signal Transduction in Halobacteria....Pages 282-301
Control of Bacterial Growth by Membrane Processes....Pages 302-319
Carbonylcyanide-3-Chlorophenylhydrazone A Prototype Agent for the Selective Killing of Cells in Acidic Regions of Solid Tumours....Pages 320-328
Ca2+ and pH Interactions in Thrombin Stimulated Human Platelets....Pages 329-337
Structure-Function Relationships of the pCloDF13 Encoded BRP....Pages 338-343
Binding of A Bacillus Thuringiensis Delta Endotoxin to the Midgut of the Tobacco Hornworm (Manduca Sexta)....Pages 344-351
Functional Reconstitution of Photosynthetic Reaction Centre Complexes from Rhodopseudomonas Palustris....Pages 352-361
Na+/H+ Exchange In Cardiac Cells: Implications For Electrical And Mechanical Events During Intracellular pH Changes....Pages 362-371
Receptor-Mediated Inhibition of Reproductive Activity in a Schistosome-Infected Freshwater Snail....Pages 372-381
NMR Study of Gramicidin Cation Transport Across and Integration into a Lipid Membrane....Pages 382-387
Back Matter....Pages 389-390
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