Ebook: Progress in Parkinson Research

In the past five years significant progress has been made in our basic and clinical under­ standing of Parkinson's disease. The discovery that MPTP, a relatively simple molecule, is able to induce parkinsonism in otherwise healthy adult humans, and the recent interest in the possibility of "transplantation" procedures as a therapeutic modality in the treatment of Parkin­ son's disease have generated enormous interest in research related to Parkinson's disease. In this setting, the National Parkinson Foundation decided to organize a research meeting to bring together scientists actively engaged in research relevant to the study of Parkinson's disease, to accelerate its progress and to promote an exchange of ideas. This meeting took place in Janu­ ary 1988 at Key Biscayne, Florida. It was decided to publish the proceedings ofthis meeting to allow rapid documentation of the participants current findings and views regarding this rapidly of this volume follows the organization of the meeting and begins evolving field. The structure with a clinical and neuropathological review of current knowledge regarding Parkinson's dis­ ease. Since dopaminergic neurons playa major role in the pathophysiology of the disease, many of the contributions relate to some aspects of dopaminergic function including localiza­ tion, regulation, and pharmacology of dopamine receptors. A special effort has been made to provide a summary of the present knowledge of the cellular biology of the dopaminergic neurons.

---

---

Content:
Front Matter....Pages i-ix
The Current Clinical Picture Of Parkinson’S Disease....Pages 1-10
The Neuropathology Of Parkinson’S Disease....Pages 11-21
Anatomical And Pharmacological Comparisons Between Dopamine D-1 And D-2 Receptors In Mammalian Cns....Pages 23-30
Architecture Of Cholinergic Pre-And Postsynaptic Markers In The Primate Striatum....Pages 31-37
Functional Anatomy of Dopamine Receptors....Pages 39-44
New Insights Into The Regulation Of Dopamine Receptor Subtypes And Their Roles In Behavior....Pages 45-51
Dopamine Receptors And Signal Transduction....Pages 53-60
The Therapeutic Potential of D1 and D2 Dopamine Agonists in Parkinson’S Disease....Pages 61-66
Isolation And Biochemical Characterization Of The D1 And D2 Dopamine Receptors....Pages 67-76
MPTP: Twenty Questions....Pages 77-83
Search For Environmental Or Endogenous Neurotoxins Related To MPTP....Pages 85-91
MPTP Neurotoxicity And The “Biochemical” Blood-Brain Barrier....Pages 93-100
Biochemistry Of The Neurotoxic Action Of MPTP And What It May Teach Us About The Etiology Of Idiopathic Parkinsonism....Pages 101-111
A Biological Evaluation Of Some 2?-Substituted Analogs Of MPTP....Pages 113-118
Hydrogen Peroxide Production in Dopamine Neurons: Implications for Understanding Parkinson’s Disease....Pages 119-126
Studies on the Toxicity of MPTP to Dopamine Neurons in Tissue and Cell Cultures....Pages 127-136
Toxicity of Structural Analogs of 1-methyl-4-Phenyl Pyridinium (MPP+) and Related Compounds on Dopaminergic Neurons in Culture....Pages 137-143
Mechanisms of MPP+ Neurotoxicity: Oxyradical and Mitochondrial Inhibition Hypotheses....Pages 145-152
Plasticity of Mesencephalic Dopaminergic Neurons....Pages 153-161
Trophic Effects of Striatal Proteins on Central Dopaminergic Neurons in Culture....Pages 163-171
Age-Related Changes of Dopaminergic Functions....Pages 173-179
Adrenal Medulla Transplants in Rodents and Nonhuman Primates: Regenerative Responses in the Host Brain....Pages 181-186
Preliminary Evaluation and Report on Human Adrenal Medullary Grafting....Pages 187-191
Behaviorial Performance Improves After Fetal Substantia Nigra Transplant in Bonnet Monkeys with MPTP Induced Parkinsonism....Pages 193-196
Mechanisms of Action of Substantia Nigra and Adrenal Medulla Grafts....Pages 197-204
Recent Advances In Dopaminergic Implants....Pages 205-210
Reversal of Experimental Parkinsonism in African Green Monkeys Following Fetal Dopamine Neuron Transplantation....Pages 211-218
Transplantation of Human Dopaminergic Neurons in Parkinsonism: Experimental Reality and Future Clinical Feasibility....Pages 219-223
Back Matter....Pages 225-228

---

Content:
Front Matter....Pages i-ix
The Current Clinical Picture Of Parkinson’S Disease....Pages 1-10
The Neuropathology Of Parkinson’S Disease....Pages 11-21
Anatomical And Pharmacological Comparisons Between Dopamine D-1 And D-2 Receptors In Mammalian Cns....Pages 23-30
Architecture Of Cholinergic Pre-And Postsynaptic Markers In The Primate Striatum....Pages 31-37
Functional Anatomy of Dopamine Receptors....Pages 39-44
New Insights Into The Regulation Of Dopamine Receptor Subtypes And Their Roles In Behavior....Pages 45-51
Dopamine Receptors And Signal Transduction....Pages 53-60
The Therapeutic Potential of D1 and D2 Dopamine Agonists in Parkinson’S Disease....Pages 61-66
Isolation And Biochemical Characterization Of The D1 And D2 Dopamine Receptors....Pages 67-76
MPTP: Twenty Questions....Pages 77-83
Search For Environmental Or Endogenous Neurotoxins Related To MPTP....Pages 85-91
MPTP Neurotoxicity And The “Biochemical” Blood-Brain Barrier....Pages 93-100
Biochemistry Of The Neurotoxic Action Of MPTP And What It May Teach Us About The Etiology Of Idiopathic Parkinsonism....Pages 101-111
A Biological Evaluation Of Some 2?-Substituted Analogs Of MPTP....Pages 113-118
Hydrogen Peroxide Production in Dopamine Neurons: Implications for Understanding Parkinson’s Disease....Pages 119-126
Studies on the Toxicity of MPTP to Dopamine Neurons in Tissue and Cell Cultures....Pages 127-136
Toxicity of Structural Analogs of 1-methyl-4-Phenyl Pyridinium (MPP+) and Related Compounds on Dopaminergic Neurons in Culture....Pages 137-143
Mechanisms of MPP+ Neurotoxicity: Oxyradical and Mitochondrial Inhibition Hypotheses....Pages 145-152
Plasticity of Mesencephalic Dopaminergic Neurons....Pages 153-161
Trophic Effects of Striatal Proteins on Central Dopaminergic Neurons in Culture....Pages 163-171
Age-Related Changes of Dopaminergic Functions....Pages 173-179
Adrenal Medulla Transplants in Rodents and Nonhuman Primates: Regenerative Responses in the Host Brain....Pages 181-186
Preliminary Evaluation and Report on Human Adrenal Medullary Grafting....Pages 187-191
Behaviorial Performance Improves After Fetal Substantia Nigra Transplant in Bonnet Monkeys with MPTP Induced Parkinsonism....Pages 193-196
Mechanisms of Action of Substantia Nigra and Adrenal Medulla Grafts....Pages 197-204
Recent Advances In Dopaminergic Implants....Pages 205-210
Reversal of Experimental Parkinsonism in African Green Monkeys Following Fetal Dopamine Neuron Transplantation....Pages 211-218
Transplantation of Human Dopaminergic Neurons in Parkinsonism: Experimental Reality and Future Clinical Feasibility....Pages 219-223
Back Matter....Pages 225-228
....