Ebook: Contraception Research for Today and the Nineties: Progress in Birth Control Vaccines

The twentieth century will close with 5 billion people added to the current global population. Between 1980 and the year 2000, the total world population will increase from 4 billion 10 a liUle over 6 billion. There will be half as many morc people on earth during these 20 years than the number accumulated since the origin of man to 1980. Overpopulation is particularly acute in economically developing countries, where contraception has become a social necessity. Comraceplion Researcll for Today and Ihe Nineties carries the proceedings of an international symposium convened in New Delhi in October, 1986, to review the status of current research in contraception. Major organizations supporting basic and applied research in contraception-The Population Council, World Health Organization (WHO), The Rockefeller Foundation, United States Agency for International Development (USAID), International Development Research Center of Canada (IDRC), National Institutes of Health (NIH), and the Indian Council of Medical Research (ICMR)- were represented by the heads of divi­ sions who projected respective programs and strategies. Principal scientists responsible for many of the new leads participated.

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The inauguration of the new National Institute of Immunology, New Delhi, India, drew foremost investigators from all corners of the scientific community to discuss the timely topic Contraception Research for Today and the Nineties. This volume contains the latest findings and the latest thinking on the following broad topics: - Population Control and Development - New Contraceptive Methods at Phase II, III, IV - Neuroendocrine Regulations - Immunobiology of Pregnancy - Birth Control Vaccines - Gamete Antigens - Basic Discussion of Fertility Control by Immunology

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The inauguration of the new National Institute of Immunology, New Delhi, India, drew foremost investigators from all corners of the scientific community to discuss the timely topic Contraception Research for Today and the Nineties. This volume contains the latest findings and the latest thinking on the following broad topics: - Population Control and Development - New Contraceptive Methods at Phase II, III, IV - Neuroendocrine Regulations - Immunobiology of Pregnancy - Birth Control Vaccines - Gamete Antigens - Basic Discussion of Fertility Control by Immunology
Content:
Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Demographic Trends, Global and Indian Scene, and Implications....Pages 3-8
Population Control: Strategies and Experience....Pages 9-16
WHO Special Programme in Human Reproduction and Contraceptive Needs of Developing Countries....Pages 17-26
Front Matter....Pages 27-27
Steroid Implants for Long-Term Contraception....Pages 29-35
The Levonorgestrel-Releasing IUD....Pages 37-48
Antiprogestin Ru 486: A Contragestive Agent....Pages 49-66
Vaginal Pills: Systemic Contraception Induced by Vaginal Administration of Contraceptive Pills....Pages 67-79
Front Matter....Pages 81-81
Neuroendocrine Regulation of Fertility....Pages 83-91
GnRH Analogs in Contraception....Pages 93-100
A Novel Hypothalamic Peptide Inhibitor of Prolactin Secretion....Pages 101-113
Inhibin: Chemistry, Measurement, Physiology, and Its Potential as a Fertility-Regulating Agent....Pages 115-129
Front Matter....Pages 131-131
Immunobiology of Human Trophoblast....Pages 133-142
Maternal-Placental Interactions in Early Human Pregnancy....Pages 143-149
Maternal-Blastocyst Interaction at Implantation....Pages 151-160
Immunogenetic Control of Pregnancy and Development....Pages 161-169
Cell-Mediated Immune Mechanisms in Recurrent Spontaneous Abortion....Pages 171-180
Front Matter....Pages 181-181
Birth Control Vaccines Inducing Antibodies Against Chorionic Gonadotropin....Pages 183-197
Cloning and Expression of Gonadotropin Hormone Genes....Pages 199-206
Hormonal Regulation of Pituitary Gonadotropin Gene Expression....Pages 207-215
Active Immunization of Rhesus Monkeys Against the ?-Subunit of Ovine Luteinizing Hormone: Evaluation of Safety and Effectiveness of an Antigonadotropin Vaccine....Pages 217-230
Front Matter....Pages 181-181
Safety Evaluation of HCG Vaccine in Primates: Autoantibody Production....Pages 231-239
Potential of LH Receptor as an Immunocontraceptive Vaccine: Studies in the Baboon (Papio)....Pages 241-252
Front Matter....Pages 253-258
Hormonal and Cellular Control of Seminiferous Tubular Function....Pages 259-259
LDH-C4 as the Model Sperm Antigen for a Contraceptive Vaccine....Pages 261-276
Should Cell-Mediated Immunity be Considered in the Implementation of Antifertility Vaccines?....Pages 277-283
Contraceptive Potential of Secretory Immunity....Pages 285-291
Establishment of Human-Mouse Hybridoma to Human Seminal Plasma Antigen and Its Contribution to a Contraceptive Vaccine....Pages 293-302
An Immunoreactive Human Sperm Antigen in Rat Spermatogenic Cells....Pages 303-314
Role of the Fertilization Antigen (FA-1) in Immunoregulation of Fertility and Involuntary Infertility in Humans....Pages 315-322
Origin of Zona Pellucida Antigens and Its Relevance to the Development of Contraceptive Vaccine....Pages 323-339
Disillusions and Hopes About Zona Pellucida Glycoproteins....Pages 341-343
Front Matter....Pages 345-356
New Developments in Epitope Analysis....Pages 357-357
Immunological Difficulties and Requirements for Immune Manipulations in the Field of Reproduction....Pages 359-367
The Past Is Prologue: Implications of the Symposium....Pages 369-384
Back Matter....Pages 385-388
....Pages 389-401