Ebook: Mycobacterium tuberculosis: Interactions with the Immune System
- Tags: Immunology, Infectious Diseases, Medical Microbiology, Plant Sciences, Animal Anatomy / Morphology / Histology, Microbial Ecology
- Series: Infectious Agents and Pathogenesis
- Year: 1988
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
Tuberculosis once again occupies a special position in the areas of infec tious diseases and microbiology. This disease has been important to mankind since even before biblical times. Tuberculosis has been a major cause of morbidity and mortality in humans, especially in highly ur banized Europe, until a few decades ago. Indeed, this disease became a center of many novels, plays, and operas, since it appeared to be quite popular to have the heroine dying of "consumption. " Most importantly, tuberculosis also became the focus of attention for many investigations during the 19th and even the 20th centuries. Major advances were made in the areas of isolation and identification of M. tuberculosis and related microorganisms. The discovery, by Robert Koch, that tuberculosis was caused by an infectious agent revolutionized our thinking about dis eases. Koch's postulates were developed with tuberculosis in mind and became a focal point for many advances in microbiology and medicine. Studies with mycobacteria as a central focus have also led to revolu tionary new concepts about immunology in general. Koch himself showed that those exposed to M. tuberculosis develop a skin hypersen sitivity or allergy to the microorganism's antigens, an observation which was the starting point for many important developments. Indeed, imme diate-type hypersensitivity and atopic or IgE-mediated allergy were de fined in relation to the delayed-type cutaneous hypersensitivity evi denced with the tubercle bacillus.
Content:
Front Matter....Pages i-xxi
Mycobacterial Antigens....Pages 1-37
Role of Adjuvant and Immunogenic Moieties of M. tuberculosis in Pathogenicity....Pages 39-58
Genetic Background of the Host and Expression of Natural Resistance and Acquired Immunity to M. tuberculosis ....Pages 59-79
Immune Response to Mycobacteria....Pages 81-98
The Tubercle Bacillus—Human Macrophage Relationship Studied In Vitro ....Pages 99-135
Regulation and Pharmacology of Granulomatous Inflammation....Pages 137-150
Cytolytic Cells in M. tuberculosis Infections....Pages 151-170
Anergy and Other Immunologic Perturbances in Mycobacterial Infections....Pages 171-205
Anergy in Experimental Mouse Models of Mycobacterial Infection....Pages 207-225
Suppressor Cells in Mycobacterial Infections....Pages 227-241
Immunoregulatory Function of Mononuclear Phagocytes in Tuberculosis....Pages 243-262
Role of B Lymphocytes and Antibodies in the Regulation of Cell-Mediated Immune Reactions to BCG in Mice....Pages 263-275
Polyclonal Lymphocyte Activation by M. tuberculosis and Its Products....Pages 277-304
Mechanisms of Toxicity of Tubercle Bacilli for Macrophages....Pages 305-325
Mycobacterium-Induced Suppressor Cells and Their Clinical Importance....Pages 327-340
The Protective Effects of BCG Vaccination against Tuberculosis....Pages 341-370
Changing Faces of Clinical Tuberculosis....Pages 371-388
Mycobacterium avium-Complex Infections and Immunodeficiency....Pages 389-414
Back Matter....Pages 415-426
Content:
Front Matter....Pages i-xxi
Mycobacterial Antigens....Pages 1-37
Role of Adjuvant and Immunogenic Moieties of M. tuberculosis in Pathogenicity....Pages 39-58
Genetic Background of the Host and Expression of Natural Resistance and Acquired Immunity to M. tuberculosis ....Pages 59-79
Immune Response to Mycobacteria....Pages 81-98
The Tubercle Bacillus—Human Macrophage Relationship Studied In Vitro ....Pages 99-135
Regulation and Pharmacology of Granulomatous Inflammation....Pages 137-150
Cytolytic Cells in M. tuberculosis Infections....Pages 151-170
Anergy and Other Immunologic Perturbances in Mycobacterial Infections....Pages 171-205
Anergy in Experimental Mouse Models of Mycobacterial Infection....Pages 207-225
Suppressor Cells in Mycobacterial Infections....Pages 227-241
Immunoregulatory Function of Mononuclear Phagocytes in Tuberculosis....Pages 243-262
Role of B Lymphocytes and Antibodies in the Regulation of Cell-Mediated Immune Reactions to BCG in Mice....Pages 263-275
Polyclonal Lymphocyte Activation by M. tuberculosis and Its Products....Pages 277-304
Mechanisms of Toxicity of Tubercle Bacilli for Macrophages....Pages 305-325
Mycobacterium-Induced Suppressor Cells and Their Clinical Importance....Pages 327-340
The Protective Effects of BCG Vaccination against Tuberculosis....Pages 341-370
Changing Faces of Clinical Tuberculosis....Pages 371-388
Mycobacterium avium-Complex Infections and Immunodeficiency....Pages 389-414
Back Matter....Pages 415-426
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