Ebook: Cellular and Molecular Basis of Synaptic Transmission

Major progresses in the study of the cellular and molecular basis of synaptic transmission of nerve cells are highlighted. Each individual contribution gives an overview of the subject, presenting a description of the technical approach and considering future perspectives of the developments in the field. Topics range from historical aspects of the development of biochemical studies on synaptic transmission to the most advanced techniques applicable in morphological and functional studies of the nerve terminal. Studies on synaptic vesicles, the regulation of presynaptic transmitter synthesis, transmitter-release and especially the molecular structure and function of presynaptic ion channels and of transmitter receptors offer a detailed insight into synaptic events.

---

Major progresses in the study of the cellular and molecular basis of synaptic transmission of nerve cells are highlighted. Each individual contribution gives an overview of the subject, presenting a description of the technical approach and considering future perspectives of the developments in the field. Topics range from historical aspects of the development of biochemical studies on synaptic transmission to the most advanced techniques applicable in morphological and functional studies of the nerve terminal. Studies on synaptic vesicles, the regulation of presynaptic transmitter synthesis, transmitter-release and especially the molecular structure and function of presynaptic ion channels and of transmitter receptors offer a detailed insight into synaptic events.

---

Major progresses in the study of the cellular and molecular basis of synaptic transmission of nerve cells are highlighted. Each individual contribution gives an overview of the subject, presenting a description of the technical approach and considering future perspectives of the developments in the field. Topics range from historical aspects of the development of biochemical studies on synaptic transmission to the most advanced techniques applicable in morphological and functional studies of the nerve terminal. Studies on synaptic vesicles, the regulation of presynaptic transmitter synthesis, transmitter-release and especially the molecular structure and function of presynaptic ion channels and of transmitter receptors offer a detailed insight into synaptic events.
Content:
Front Matter....Pages I-XV
The Cellular Basis of Synaptic Transmission: An Overview....Pages 1-23
Specializations of Subsynaptic Cytoplasms. Comparison of Axospinous Synapses and Neuromuscular Junctions....Pages 25-50
New Evidence Supporting the Vesicle Hypothesis for Quantal Secretion at the Neuromuscular Junction....Pages 51-72
Synaptic Vesicle Classes in Torpedo and Skate Electric Organ and Muscle....Pages 73-82
Effect of Nerve Stimulation, K+ Saline and Hypertonic Saline on Classes of Quanta, Quantal Content and Synaptic Vesicle Size Distribution of Torpedo Electric Organ....Pages 83-95
Fine Structural Correlates of Calcium Dynamics in the Presynaptic Terminal....Pages 97-120
Differential Release of Transmitters and Neuropeptides Co-Stored in Central and Peripheral Neurons....Pages 121-135
The Detection, Isolation and Properties of Sub-Populations of Mammalian Brain Synaptosomes of Defined Neurotransmitter Type....Pages 137-151
Excitatory Amino Acids; Physiology, Anatomy and Biochemistry....Pages 153-169
Synaptosomal Bioenergetics and the Mechanism of Amino Acid Transmitter Release....Pages 171-183
Heterologous Carriers Located on Rat CNS Nerve Endings and their Possible Role in the Modulation of Transmitter Release....Pages 185-198
Spontaneous Release of Acetylcholine from Torpedo Electromotor Neurons....Pages 199-213
The Mechanism of Acetylcholine Release: Its Essential Component, the Mediatophore....Pages 215-227
Potassium Channels in Rat Brain Synaptosomes: Pharmacology and Toxicology....Pages 229-239
Calcium Channels and Na+/Ca2+ Exchange in Synaptosomes....Pages 241-261
Properties of Presynaptic Voltage-Sensitive Calcium Channels in Rat Synaptosomes....Pages 263-284
Mechanisms of Failure of Synaptic Transmission During Anoxia....Pages 285-291
Adrenergic and Cholinergic Vesicles: Are there Common Antigens and Common Properties?....Pages 293-304
Structure and Function of Synaptic Vesicles:New Aspects....Pages 305-314
Complexity and Regulation in the Acetylcholine Storage System of Synaptic Vesicles....Pages 315-324
Synaptic Vesicle Proteins....Pages 325-335
Synaptophysin: A Major Cell Type-Specific Vesicle Protein of Neuroendocrine Cells....Pages 337-350
The New Paradigm: Sympathetic Neurotransmission by Lateral Interaction Between Single Mixed Quanta Acting in Two Different Biophases....Pages 351-356
Sympatho-Adrenal Co-Storage, Release and Synthesis of Enkephalins and Catecholamines Induced by Acute CNS Ischemia in Pig....Pages 357-375
Extracellular Metabolism of ATP at the Cholinergic Electromotor Synapse: Characterization and Location of Ectonucleotidases....Pages 377-393
The Application of Immunoaffinity Techniques to the Study of Cholinergic Neurobiology....Pages 395-410
Transmitter/Modulator Induced Events Related to Excitation-Contraction Coupling in Skeletal Muscle of Vertebrates. Action of ATP.....Pages 411-424
Identity and Functional Role of Neuropeptides in Torpedo Electric Organ....Pages 425-441
Mechanisms Regulating the Expression and Function of Acetylcholine Receptor....Pages 443-452
Antibodies as Probes of the Structure of the Nicotinic Acetylcholine Receptor....Pages 453-461
Brain ?-Neurotoxin-Binding Proteins and Nicotinic Acetylcholine Receptors....Pages 463-473
Human Neuroblastoma Cells: An in Vitro Model for the Study of Mammalian Neuronal Nicotinic Receptors....Pages 475-492
Molecular Biology Approaches to the Function and Development of CNS Synapses.....Pages 493-506
Recent Studies on Opioid Receptors....Pages 507-524
Back Matter....Pages 525-539
....Pages 541-550