Ebook: Histophysiology of the Immune System: The Life History, Organization, and Interactions of Its Cell Populations

The 9th International Conference on Lymphatic Tissues and Germinal Centres in Immune Reactions was held in Oslo, 9-14 August, 1987. These conferen­ ces, by the regular devotees just referred to as the germinal centre con­ ferences or GCC, have been held regularly at roughly three-year intervals since 1966. The credo of these conferences is "in vivo veritas", signifying that investigating components, like molecules and cells, only gives partial truth. The components must ultimately be explored in their natural con­ text, to see how they interact with other parts and are integrated to a whole. To the biologist it is obvious that the world must be investigated at many different levels of organization. At each level the patterns observed represent just some of many possible ways of putting together the elements of the lower levels. These patterns are not predetermined, but the results of evolution, i.e. of a history in which stochastic processes play a major role. The organic world can therefore not be torn apart and then reconstructed from basic principles alone. This realization is often expressed as the whole being more than the sum of its parts.

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Content:
Front Matter....Pages i-xxi
Front Matter....Pages 1-1
The Leukocyte-Common Antigen (L-CA) Family....Pages 3-7
The Poly-Ig Receptor — Functional Aspects of Secretory Component Expression....Pages 9-20
Lymphocyte Migration Molecules....Pages 21-29
The Binding of Antigen Presenting Cells to T Lymphocytes....Pages 31-41
Front Matter....Pages 43-43
In Vivo Localization of B Lymphoctye Progenitor Cells in Mouse Bone Marrow....Pages 45-51
Pattern of Distribution of Early B Lineage Cells in Rat Bone Marrow....Pages 53-56
B Cell Precursor Populations in Fetal and Neonatal Rat Liver: Frequency, Topography and Antigenic Phenotype....Pages 57-62
Rat Immunoglobulin Genes have Comparable Patterns of JH Rearrangement in Normal Peripheral B Cells and In Pre-B And Cultured TdT+ Cells from Bone Marrow....Pages 63-68
Chicken B Lymphocyte Differentiation: Bursal Microenvironment and Differences in Ontogeny between Normal and SPF Birds....Pages 69-74
Response of the Chicken Bursal Stroma to Treatment with Cyclophosphamide and IBD Virus....Pages 75-80
Age-Dependence of Lymphocyte Production in Peyer’s Patch Follicles in Contrast to the Other Peyer’s Patch Compartments and the Thymus....Pages 81-85
Migration of Newly-Produced Virgin B Cells from Bone Marrow to Secondary Lymphoid Organs....Pages 87-92
Memory B Cells Generated in T Cell-Dependent Antibody Responses Colonise the Splenic Marginal Zone....Pages 93-98
Marginal Zone B Cells and the Localisation of Antigen on Follicular Dendritic Cells....Pages 99-104
CBA/N Mice have Marginal Zone B Cells with Normal Surface Immunoglobulin Phenotype....Pages 105-111
Thymus-Independent Type 2 Responses in Lymph Nodes....Pages 113-117
Both LY-1 B Cells And Conventional B Cells Make Autoantibodies to Bromelain-Treated Autologous Erythrocytes....Pages 119-123
IgG Subclass Distribution in Juvenile Human Tonsil: IgG3 and IgG4 Results of Specific Antibody Production Using Synthetic Peptides....Pages 125-132
Interrelationships of Cell-Substrate and Cell-Cell Adhesion Structures in B-Chronic Lymphocytic Leukemia (B-CLL) Cells....Pages 133-137
Heterogeneity in the Expression of B-Cell Antigen in Non-Hodgkin’s Lymphoma....Pages 139-144
Front Matter....Pages 43-43
Growth Requirements of SJL Lymphomas in Vitro: Effect of BCGF II....Pages 145-153
Morphologicl Diversity of DRC-1 Pospitive Cells: Human Follicular Dendritic Cells and their Relatives....Pages 157-163
Identification of Alkaline Phosphatase Positive Cells in Human Germinal Centres as Follicular Dendritic Cells....Pages 165-169
Isolation of Follicular Dendritic Cells from Human Tonsils and Adenoids. in Vitro Culture....Pages 171-175
Immunohistochemical Study on Cultured FDC-C Enriched Lymphoid Cell Populations....Pages 177-180
Interactions Between Follicular Dendritic Cells and Lymphoid Cells....Pages 181-184
Deposits of Terminal Complement Complex and S-Protein on Follicular Dendritic Cells in Human Lymphoid Tissue....Pages 185-189
Transport of Immune Complexes from the Subcapsular Sinus into the Lymph Node Follicles of the Rat....Pages 191-196
FDC-Iccosome Mediated Antigen Delivery to Germinal Center B Cells, Antigen Processing and Presentation to T Cells....Pages 197-202
Is the Survival of Memory B Cells Dependent on the Persistence of Antigen?....Pages 203-207
Memory B Cells but not Virgin B Cells are Activated in Germinal Centers....Pages 209-214
A Subpopulation of Germinal Center B Cells Differentiate Directly into Antibody Forming Cells upon Secondary Immunization....Pages 215-220
Specific Antibody Forming Cells in Lymphoid Follicles of Spleen: An Aspect of the Late Immune Response....Pages 221-225
Enrichment of Germinal Centre Cells....Pages 227-232
The Germinal Center Precursor Cell is Surface ? and ? Positive....Pages 233-237
Surface IgD Phenotype of Rat Germinal Centre Precursor Cells....Pages 239-243
The De Novo Generation of Germinal Centers is an Oligoclonal Process....Pages 245-250
Changes in the Germinal Centre and Lymphocytic Corona after Peritoneal Inflammation....Pages 251-251
The Cholinergic and Adrenergic Innervation of the Rat Thymus....Pages 255-261
Complex Heterogeneity of the Thymic Stroma....Pages 263-268
Front Matter....Pages 43-43
Thymic Stromal Elements Defined by M.Abs: Ontogeny, and Modulation in Vivo By Immunosuppression....Pages 269-275
Kinetics of Rat Thymic Dendritic Cells in Bone Marrow-Reconstituted Radiation Chimeras....Pages 277-283
Allogeneic Cultured Thymic Fragments in Congenitally Athymic (NUDE) Rats....Pages 285-292
Studies on Thymic Involution: Growth Potential and DNA Repair of the Stromal Cells....Pages 293-298
Production of Interleukin 1 (IL1) by Human Thymic Epithelial Cells (TEC)....Pages 299-305
A Low Density Fraction of Bone Marrow Cells Enriched in Prothymocyte Activity....Pages 307-313
Kinetics of Thymocyte Regeneration in Adult Adriamycin Treated Rats: Evidence for a Bone Marrow Derived Prothymocyte Precursor....Pages 315-321
A Study of Early Events During T Cell Differentiation in Thymic Grafted Nude Mice....Pages 323-331
Vascular Thymustransplantation in Rats: A New Method to Study Thymocyte Kinetics....Pages 333-338
M Receptor and Differentiation of T Lymphocytes in the Developing Human Thymus....Pages 339-344
Homing Receptor Expression in Grafts of Purified Thymic Epithelium....Pages 345-349
In Vitro Binding of L3T4?Lyt-2? Pgp-1+ Thymocytes to Thymic Accessory Cells....Pages 351-356
Structural and Cellular Changes in the Mouse Thymus During Pregnancy....Pages 357-362
Analysis of Lymphocyte Phenotype in Human Thymomas....Pages 363-368
Thymic Hyperplasia in Myasthenia Gravis: Immuno-Histological Abnormalities and Responsiveness to Recombinant IL2....Pages 369-374
Thymus Homing and Recostitution in Split Dose Irradiated Preleukemic Mice....Pages 375-381
Synovial T Cells Detect Polymorphism of Class II HLA Antigens....Pages 383-386
Activated Inflammatory T Lymphocytes in Rheumatoid Synovitis — Effect of Cyclosporine A and Anti-Tac....Pages 387-392
Inhibition of Splenic T Lymphocytes and Accessory Cell Interaction by Anti-Mac-1 (Monoclonal Antibody to Complement Receptor Type 3)....Pages 393-395
Front Matter....Pages 397-400
Mycobacterium Tuberculosis Antigen Specific Human T-Cell Lines are Cytolytic to Autologous Antigen Pulsed Macrophages....Pages 43-43
Correlation of IL2 Production and Lymphoid Tissue Make-Up in Two Inbred Strains of Rats....Pages 401-406
p145-MR6: A Novel T Cell Surface Molecule with a Role in Tolerance to Self....Pages 407-411
Suppression of Immunoglobulin Production by Germinal Centre HNK-1+ CD3+ Cells....Pages 413-417
Mast Cell Response To Tumor Graft....Pages 421-425
Interleukin-2 Induced Changes in Mononuclear Cell Surface Charge....Pages 427-432
The Target Cells for Rat NK Cells among Allogeneic Bone Marrow Cells....Pages 433-438
Are Lymphokine Activated Killer Cells a Possible Form of Leukaemia Immunotherapy?....Pages 439-445
Blood Leukocyte Natural Killer Activity as an Early Diagnostic Indicator of Leukaemic Relapse....Pages 447-450
Proliferation of Large Granular Lymphocytes in the Rat....Pages 451-455
Establishment of Lymph Node Derived Endothelial Cell Lines Which Show Lymphoid Cell Binding....Pages 457-461
The Expression of Lymphocyte Adhesion Molecules on Cultured High Endothelial Cells....Pages 465-470
Expression and Regulation of an Antigen Specific for Endothelium Involved in Human Lymphocyte Homing....Pages 471-476
Changes in Lymphocyte Binding and Expression of his 22 of High Endothelial Venules in Rat Lymph Nodes after Occlusion of Afferent Lymph Flow....Pages 477-484
Regulation of Functional and Morphological Aspects of High Endothelium in Mouse....Pages 485-490
Substance P-Mediated Modulation of the Primary Antibody Response....Pages 491-497
MEL-14 and LFA-1, Organ Specific and Non-Specific Adhesion Molecules Involved in Homing of Human Lymphocytes....Pages 499-503
Homing Receptor Expression and Migration of Activated Lymphocytes....Pages 505-509
Reversibility of Loss of Homing Receptor Expression Following Activation....Pages 511-518
Endocytic Stripping of Ligands from Migrant Lymphocytes in High Endothelial Venules (HEV): Implications for Immunomodulation vs Viral Pathogenesis....Pages 519-524
Front Matter....Pages 525-531
Xenogeneic Lymphocyte Migration in the Foetal Lamb and Unsuckled Neonatal Piglet: Evidence for the Evolutionary Conservation and Heterogeneity of Migration Determinants....Pages 43-43
Hev Development and Trypsin-Inhibitable Localization of Lymphocytes in the Reaction to Intradermal Pha: a Receptor-Dependent Immigration and Possible Model for Peripheral CMI Reactions?....Pages 533-539
The Migration of Lymphocyte Subsets from Blood to Lymph in the Normal Rat....Pages 541-546
The Physiological Role of the Lung in Lymphocyte Migration....Pages 547-551
Lymphocyte Emigration from the Ovine Thymus: Characterization of Lymphatic Emigrants and Venous Emigrants....Pages 553-558
T Lymphocyte Precursors Migrate Towards Chemotactic Peptides Secreted by Embryonic or Juvenile Thymus....Pages 559-563
Microvasculature of the Sheep Thymus....Pages 565-570
Tissue Localization and Migration of Murine Spleen Macrophages Carrying the Forssman Glycosphingolipid Antigen....Pages 571-575
Migration Patterns of Dendritic cells in the Mouse....Pages 577-582
A Monoclonal Antibody which Reacts Specifically with a Population of Bovine Lymphocytes Lacking B cell and T cell Markers....Pages 583-589
Meckel’s Diverticle: A Gut Associated Lymphoid Organ in Chickens....Pages 591-596
Subpopulations of Non-Lymphoid Cells in Bronchus Associated Lymphoid Tissue and Lung of the Mouse....Pages 599-605
Migration and Lodging of Peyer’s Patch IgA Precursor Cells in the Gut Lamina Propria....Pages 607-613
Localization, Isolation and Histochemical Characterization of Macrophages in the Gut and Mesenteric Lymph Nodes of the Rat....Pages 615-619
Direct Transdiaphragmatic Traffic of Peritoneal Macrophages to the Lung....Pages 621-626
Quantification and Class Distribution of Immunoglobulin-Secreting Cells in Mucosal Tissues of the Chicken....Pages 627-632
The Identification of Murine Peyer’s Patch T Cell-Derived Factors which Enhance IgA Responses....Pages 633-639
Role of the Galt Contrasuppressor T Cell Circuit in Isotype-Specific Immunoregulation....Pages 641-647
Evidence for Contrasuppression in Patients with Crohn’s Disease....Pages 649-653
Activated Fc Alpha T Cells in Crohn’s Disease are Involved in Regulation of IgA....Pages 655-663
Front Matter....Pages 665-673
Induction of a Combined Mucosal and Systemic Anti-Ovalbumin Response....Pages 43-43
Differential Expression of Epithelial MHC Class II Determinants (HLA-DR, -DP, and -DQ) and Increased Class I Expression in Inflamed Salivary Glands....Pages 675-680
Jejunal Epithelium of Patients with Coeliac Disease Shows Enhanced Expression of MHC Class II Subregion Products....Pages 681-688
T Cells and Epithelial Expression of HLA Class II Determinants in Relation to Putative M Cells of Follicle-Associated Epithelium in Human Peyer’s Patches....Pages 689-693
Modulation of Histamine Secretion from Rat and Human Mast Cell Subpopulations....Pages 695-698
Mucosal Priming Alters Pathogenesis of Rift Valley Fever....Pages 699-704
J Chain is Expressed by More IgA2-than IgA1-Producing Cells in Colonic Mucosa, but it is Reduced in Both Subclasses in Inflammatory Bowel Disease....Pages 705-715
Ontogeny of Macrophages and Dendritic Cells of the Rat....Pages 717-723
Postnatal Development of Non-Lymphoid and Lymphoid Cell Populations in Situ in Diabetes-Prone BB Rats....Pages 725-728
Immunological Characteristics of Milky Spots in the Omentum of Rats....Pages 731-736
Lymphoid Dendritic Cells in Rheumatoid Tissue and Normal Blood — Characteristics and Functions....Pages 737-743
Interdigitating Cells and Dendritic Cells of the Mouse Identified by Monoclonal Antibodies: Interaction with Lymphocyte Subsets....Pages 745-750
Phenotypic Changes in Cultured Rat Dendritic Cells: Expression of IL-2 Receptor, Thy-1 and Other Antigens....Pages 751-755
Lymph Node Macrophage Heterogeneity: A Subpopulation Fails to Express Activation Phenotype....Pages 757-763
Induction of the Expression of an FcR for Monomeric Rat IgG2b on Rat Peritoneal Macrophages....Pages 765-769
Activation of Mononuclear Phagocyte Functions by Structurally Different Bacterial Endotoxins....Pages 771-776
Expression and Function of MHC Class II Antigens on Macrophages and Dendritic Cells....Pages 777-781
Induction of Class II MHC Antigen Expression in Rat Organs after Systemic Application of Recombinant Gamma Interferon....Pages 783-787
Human Peritoneal Macrophages Enhance HLA-DR Expression in Culture and are Very Potent Stimulators of an Allogeneic Mixed Leucocyte Reaction....Pages 789-793
Front Matter....Pages 795-799
The Effects of Bacterial Lipopolysaccharide (LPS) on High Endothelial Venules, T Lymphocytes and Interdigitating Cells in Mouse Lymph Nodes....Pages 801-806
Intestinal Uptake of Carrageenan: Distribution and Effects on Humoral Immune Competence....Pages 43-43
Carrageenan Induced Changes in the Immunomodulatory Capacity of Macrophages: An in Vitro Study....Pages 807-811
Immunoregulation in Epidermis: Glucocorticoids Induced Epidermal Cell Derived Inhibitor of Interleukin 1 Activity....Pages 813-820
Monocyte Defect Causes Decreased Automlr in Multiple Sclerosis Patients....Pages 821-832
Morphological Studies on Mitogen and Antigen Presentation by Human and Rabbit Cells....Pages 833-837
Physical Interaction Between Dendritic Cells and Lymphocytes is not LFA-1 Mediated....Pages 839-842
The Involvement of T-Cells in the Stimulatory Effect of a Water-in-Oil Emulsion on the B-Cell Response....Pages 843-848
Impact of IgD Receptor-Positive T Cells on the Immune Response....Pages 849-854
Spectrotype Modulation of BALB/C Anti (1-3>) Dextran 1355S Responses....Pages 855-860
B Lymphoma Cells Process and Present their Endogenous Ig: Implications for Network Theory....Pages 861-870
Germinal Center B Cells Present Antigen Obtained in vivo to T Cells in vitro and Stimulate Mixed Lymphocyte Reactions....Pages 871-875
Characterization of Cell Populations, Reappearing in the Mouse Spleen After Elimination by Liposome Encapsulated Dichloromethylene Diphosphonate: Reappearance of Marginal Zone Lymphocytes is Independent of Marginal Zone Macrophages....Pages 877-882
Localization of TI2 Antigen (Ficoll-FITC) and Corresponding Specific Anti-FITC Antibody Forming Cells in the Rat Spleen....Pages 883-888
In Vitro Infection of Human Epidermal Langerhans Cells with HIV....Pages 889-893
Accessory Cell Neoplasia as a Result of the Breakdown of Immunological Regulation?....Pages 895-899
Back Matter....Pages 901-905
....Pages 907-912