Ebook: Immunotoxins

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Un­ fortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up-to-date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

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Content:
Front Matter....Pages i-xix
Introduction....Pages 1-7
Front Matter....Pages 9-9
Toxin structure....Pages 11-24
Structure—activity relationships in diphtheria toxin and Pseudomonas aeruginosa exotoxin A....Pages 25-35
Front Matter....Pages 37-37
How protein toxins enter and kill cells....Pages 39-73
Mechanism of action of ricin and related toxins on the inactivation of eukaryotic ribosomes....Pages 75-89
Front Matter....Pages 91-91
Toxin selection and modification — Overview....Pages 93-96
Toxin selection and modification: Utilization of the A chain of ricin....Pages 97-111
Genetic engineering of immunotoxins....Pages 113-122
Diphtheria-related peptide hormone gene fusions: A molecular genetic approach to chimeric toxin development....Pages 123-140
Immunotoxins containing ricin....Pages 141-159
Immunotoxins containing single chain ribosome-inactivating proteins....Pages 161-173
Front Matter....Pages 175-209
Antibody-toxin conjugation....Pages 211-211
Effect of chemical linkage upon the stability and cytotoxic activity of A chain immunotoxins....Pages 213-237
Front Matter....Pages 239-251
Immunotoxins: Selection of cell-surface antigens and their corresponding monoclonal antibodies....Pages 253-253
Front Matter....Pages 255-277
Hormone, lectin and toxin-toxin conjugates....Pages 279-279
Growth factors and other ligands....Pages 281-295
Front Matter....Pages 297-320
Purification and biochemical characterization of immunotoxins....Pages 321-321
Front Matter....Pages 323-348
Immunotoxin enhancers....Pages 349-349
Enhancement of immunotoxin action: Manipulation of the cellular routing of proteins....Pages 351-369
Front Matter....Pages 371-389
Methods for quantifying immunotoxin efficacy....Pages 391-391
Kinetic analysis of cytotoxicity....Pages 393-404
Isolation and analysis of somatic cell mutants resistant to toxin conjugates....Pages 405-415
Front Matter....Pages 417-430
Immunotoxin therapy: Assessment by animal models....Pages 431-431
Prevention of carbohydrate-mediated clearance of ricin-containing immunotoxins by the liver....Pages 433-455
Human immune response to immunotoxins....Pages 457-473
Front Matter....Pages 475-480
Treatment of leukemia patients with T101 ricin A chain immunotoxins....Pages 481-481
Clinical studies: Solid tumors....Pages 483-491
Immunotoxins for ex vivo bone marrow purging in human bone marrow transplantation....Pages 493-514
Conclusion....Pages 515-535
Back Matter....Pages 537-547
....Pages 549-565