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This book is the proceedings of a NATO Advanced Studies Institute organized jointly by LNETI, the National Laboratories of the Ministry of Industry of the Portuguese Government and The Institute for Biotechnological Studies in the UK. The ASI was held in 1985 on the beautiful peninsula of Troia, once the site of a flourishing Roman salt industry. The course was the first in the NATO "Double Jump Programme" specifically aimed to promote industrial and academic participation and cooperation. As such, contributions across the whole field of biotechnology were planned and the present volume represents perspectives from specialists in different areas. Biotechnology has been defined in a recent OECD publication as "the application of scientific and engineering principles to the processing of materials by biological agents to provide goods and services" and the contents of this book, which often describe research from interdisciplinary groups, reflect this title. The value of the ASI was further enhanced by many first class poster contributions from the participants.








Content:
Front Matter....Pages i-x
Biotechnology: Opportunities and Constraints....Pages 1-10
Immobilized Cell Systems for Energy Production....Pages 11-21
Bioconversions in Organic Solvents....Pages 23-41
Enzymatic Organic Systems....Pages 43-53
Harnessing Biologically-Catalysed Electron Transfer Reactions for Biosensors....Pages 55-66
The D-Alanyl-D-Alanine-Cleaving Peptidases and ?-Lactamases. Structure and Mechanism....Pages 67-95
The Industrial Production of Monoclonal Antibodies in Cell Culture....Pages 97-109
Effect of Molecular Hydrogen on Acetate Degradation by Methanosarcina Barkeri 227....Pages 111-121
In Vitro Induction of Nitrogenase Activity in Free-Living Rhizobia by a Non-Nodulating Legume....Pages 123-130
On the Evolution of Alcohol Tolerance in Microorganisms....Pages 131-138
Industrial Applications of Plant Cell Cultures: Metabolite Production....Pages 139-153
Cloning of Genes in Streptomycetes for Secondary Metabolism....Pages 155-166
Application of Recombinant DNA Technology in Antibiotic-Producing Microorganisms....Pages 167-189
Transfer from University to Industry....Pages 191-196
Back Matter....Pages 197-207



Content:
Front Matter....Pages i-x
Biotechnology: Opportunities and Constraints....Pages 1-10
Immobilized Cell Systems for Energy Production....Pages 11-21
Bioconversions in Organic Solvents....Pages 23-41
Enzymatic Organic Systems....Pages 43-53
Harnessing Biologically-Catalysed Electron Transfer Reactions for Biosensors....Pages 55-66
The D-Alanyl-D-Alanine-Cleaving Peptidases and ?-Lactamases. Structure and Mechanism....Pages 67-95
The Industrial Production of Monoclonal Antibodies in Cell Culture....Pages 97-109
Effect of Molecular Hydrogen on Acetate Degradation by Methanosarcina Barkeri 227....Pages 111-121
In Vitro Induction of Nitrogenase Activity in Free-Living Rhizobia by a Non-Nodulating Legume....Pages 123-130
On the Evolution of Alcohol Tolerance in Microorganisms....Pages 131-138
Industrial Applications of Plant Cell Cultures: Metabolite Production....Pages 139-153
Cloning of Genes in Streptomycetes for Secondary Metabolism....Pages 155-166
Application of Recombinant DNA Technology in Antibiotic-Producing Microorganisms....Pages 167-189
Transfer from University to Industry....Pages 191-196
Back Matter....Pages 197-207
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