Ebook: New Experimental Modalities in the Control of Neoplasia

Acquisition of new knowledge about the biological and bio­ chemical nature of neoplastic cells has led to the design and development of several experimental approaches in the tre&tment of cancer. These approaches emerge from the recent work in tu­ mor virology, e. g. the control of vital cellular genes by viral regulatory signals; the implication of monoclonal antibodies as a vehicle for the targeted drug delivery and selective de­ struction of tumor cells; immunologic advances in the recog­ nition of some specific events during metastatic growth; the role of biological response modifiers in modifying or rever­ sing malignant growth; and biochemical advances, such as the role of gene amplification in drug resistance and the app­ roaches to the reversal of resistance in drug refractory cancer, the role of membranes in designing useful strategies, the identification of new enzymic targets in some types of cancer cells, and the characterization of metabolically active forms of cytostatic compounds. These are the important issues which were addressed in an international NATO Advanced Study Institute (ASI) attended by scientists from allover the world representing a wide spectrum of scientific disciplines. Although the acquired immune deficiency syndrome (AIDS) is not a malignant disease, but the etiological involvement of a retrovirus belonging to the family of human T-cell lympho­ tropic viruses which cause leukemia and lymphomas in man, justifies its inclusion in the agenda of this Study Institute. Scientific presentations from Drs.

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Content:
Front Matter....Pages i-xi
A Developmental Biologist’s View on Cancer....Pages 1-13
Oncogenes in Development, Neoplasia, and Evolution....Pages 15-40
Acquisition of Metastatic Properties via Somatic Cell Fusion: Implications for Tumor Progression in Vivo....Pages 41-55
Oncogenes and Tyrosine Kinase Activities as a Function of the Metastatic Phenotype....Pages 57-70
Immune Reactivities During the Precancer and Early Cancer Periods: Novel Approaches for Immunomodulation....Pages 71-80
Immunomodulation of Tumor Metastases....Pages 81-90
Monoclonal Antibody Targeting of Anti-Cancer Agents....Pages 91-99
Treatment of Human B Cell Lymphoma with Monoclonal Anti-Idiotype Antibodies....Pages 101-122
Human Monoclonal Antibodies Directed Against HuMTV Antigens from Human Breast Cancer Cells....Pages 123-135
Recent Advances in Thymic Hormone Research....Pages 137-164
T-Cell Growth Factor (Interleukin-2)....Pages 165-182
Drug Resistance: New Approaches to Treatment....Pages 183-193
Mechanisms of Membrane-Mediated Cytotoxicity by Adriamycin....Pages 195-202
Terminal Transferase and Adenosine Deaminase Activities in Human Neoplasia: Their Role in Modulating Cancer Treatment....Pages 203-212
Inhibitors of Terminal Transferase: A New Strategy for the Treatment of Human Leukemia....Pages 213-221
DNA-Protein Crosslinking of Platinum Coordination Complex in Living Cells: Implication to Evaluate the Cytotoxic Effects of Chemotherapeutic Agents....Pages 223-233
Antitumor Activity, Pharmacology and Clinical Trials of Elliptinium (NSC 264-137)....Pages 235-241
Therapeutic Efficacy of Oxazaphosphorines by Immunomodulation....Pages 243-247
The Role of Cellular Glutathione in Protecting Mammalian Cells from X Radiation and Chemotherapy Agents in Vitro....Pages 249-253
The Role of Papilloma Viruses in Human Cancer....Pages 255-261
Anti-Viral Vaccine Control of EB Virus-Associated Cancers....Pages 263-278
Bovine Leukosis Virus as a Model for Human Retroviruses....Pages 279-286
Human T-Lymphotropic Retroviruses and Their Role in Human Diseases....Pages 287-291
Molecular Biology of the Human T-Lymphotropic Retroviruses....Pages 293-301
Antiviral Approaches in the Treatment of Acquired Immune Deficiency Syndrome....Pages 303-328
Inhibition of HTLV-III Replication in Cell Cultures....Pages 329-342
Proteins Encoded by the Human T-Lymphotropic Virus Type III/ Lymphadenopathy Associated Virus (HTLV-III/LAV) Genes....Pages 343-356
Cytopathogenic Mechanisms Which Lead to Cell Death of HTLV III Infected T Cells....Pages 357-361
Clinical Aspects of Thymic Factors in the Treatment of Immunodeficiency Diseases and Neoplasia: Achievements and Failures....Pages 363-376
An Overview of the Current Understanding and Management of the Non-Hodgkin’s Lymphomas....Pages 377-392
Back Matter....Pages 393-402

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Content:
Front Matter....Pages i-xi
A Developmental Biologist’s View on Cancer....Pages 1-13
Oncogenes in Development, Neoplasia, and Evolution....Pages 15-40
Acquisition of Metastatic Properties via Somatic Cell Fusion: Implications for Tumor Progression in Vivo....Pages 41-55
Oncogenes and Tyrosine Kinase Activities as a Function of the Metastatic Phenotype....Pages 57-70
Immune Reactivities During the Precancer and Early Cancer Periods: Novel Approaches for Immunomodulation....Pages 71-80
Immunomodulation of Tumor Metastases....Pages 81-90
Monoclonal Antibody Targeting of Anti-Cancer Agents....Pages 91-99
Treatment of Human B Cell Lymphoma with Monoclonal Anti-Idiotype Antibodies....Pages 101-122
Human Monoclonal Antibodies Directed Against HuMTV Antigens from Human Breast Cancer Cells....Pages 123-135
Recent Advances in Thymic Hormone Research....Pages 137-164
T-Cell Growth Factor (Interleukin-2)....Pages 165-182
Drug Resistance: New Approaches to Treatment....Pages 183-193
Mechanisms of Membrane-Mediated Cytotoxicity by Adriamycin....Pages 195-202
Terminal Transferase and Adenosine Deaminase Activities in Human Neoplasia: Their Role in Modulating Cancer Treatment....Pages 203-212
Inhibitors of Terminal Transferase: A New Strategy for the Treatment of Human Leukemia....Pages 213-221
DNA-Protein Crosslinking of Platinum Coordination Complex in Living Cells: Implication to Evaluate the Cytotoxic Effects of Chemotherapeutic Agents....Pages 223-233
Antitumor Activity, Pharmacology and Clinical Trials of Elliptinium (NSC 264-137)....Pages 235-241
Therapeutic Efficacy of Oxazaphosphorines by Immunomodulation....Pages 243-247
The Role of Cellular Glutathione in Protecting Mammalian Cells from X Radiation and Chemotherapy Agents in Vitro....Pages 249-253
The Role of Papilloma Viruses in Human Cancer....Pages 255-261
Anti-Viral Vaccine Control of EB Virus-Associated Cancers....Pages 263-278
Bovine Leukosis Virus as a Model for Human Retroviruses....Pages 279-286
Human T-Lymphotropic Retroviruses and Their Role in Human Diseases....Pages 287-291
Molecular Biology of the Human T-Lymphotropic Retroviruses....Pages 293-301
Antiviral Approaches in the Treatment of Acquired Immune Deficiency Syndrome....Pages 303-328
Inhibition of HTLV-III Replication in Cell Cultures....Pages 329-342
Proteins Encoded by the Human T-Lymphotropic Virus Type III/ Lymphadenopathy Associated Virus (HTLV-III/LAV) Genes....Pages 343-356
Cytopathogenic Mechanisms Which Lead to Cell Death of HTLV III Infected T Cells....Pages 357-361
Clinical Aspects of Thymic Factors in the Treatment of Immunodeficiency Diseases and Neoplasia: Achievements and Failures....Pages 363-376
An Overview of the Current Understanding and Management of the Non-Hodgkin’s Lymphomas....Pages 377-392
Back Matter....Pages 393-402
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