Ebook: Oncogenes and Growth Control

How is growth controlled in normal cells? How are the growth control mechanisms perturbed in cancer cells? This book provides an up-to-date description of research aimed at resolving these questions. It is organized into four sections, each containing a series of short reviews written by experts in the field. The general headings are: growth factors, receptors, and related oncogenes: transduction of mitogenic signals and ras oncogenes; nuclear oncogenes and regulation of gene expression; and multiple steps involved in malignant transformation. The articles emphasize concepts rather than detailed facts and are intended not only for specialists in the field but also for interested readers, such as physicians and advanced students, who wish to stay abreast of developments in one of the most exciting fields in current biomedical research.

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How is growth controlled in normal cells? How are the growth control mechanisms perturbed in cancer cells? This book provides an up-to-date description of research aimed at resolving these questions. It is organized into four sections, each containing a series of short reviews written by experts in the field. The general headings are: growth factors, receptors, and related oncogenes: transduction of mitogenic signals and ras oncogenes; nuclear oncogenes and regulation of gene expression; and multiple steps involved in malignant transformation. The articles emphasize concepts rather than detailed facts and are intended not only for specialists in the field but also for interested readers, such as physicians and advanced students, who wish to stay abreast of developments in one of the most exciting fields in current biomedical research.

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How is growth controlled in normal cells? How are the growth control mechanisms perturbed in cancer cells? This book provides an up-to-date description of research aimed at resolving these questions. It is organized into four sections, each containing a series of short reviews written by experts in the field. The general headings are: growth factors, receptors, and related oncogenes: transduction of mitogenic signals and ras oncogenes; nuclear oncogenes and regulation of gene expression; and multiple steps involved in malignant transformation. The articles emphasize concepts rather than detailed facts and are intended not only for specialists in the field but also for interested readers, such as physicians and advanced students, who wish to stay abreast of developments in one of the most exciting fields in current biomedical research.
Content:
Front Matter....Pages I-XXIII
Introduction....Pages 1-5
Front Matter....Pages 7-8
The Expression of Growth Factors and Growth Factor Receptors During Mouse Embryogenesis....Pages 9-17
A Role for Proto-Oncogenes in Differentiation?....Pages 18-26
Front Matter....Pages 27-31
The Granulocyte-Macrophage Colony-Stimulating Factors....Pages 33-34
Role of PDGF-Like Growth Factors in Autocrine Stimulation of Growth of Normal and Transformed Cells....Pages 35-42
The Physiology of Epidermal Growth Factor....Pages 43-50
Structural Relationships Between Growth Factor Precursors and Cell Surface Receptors....Pages 51-57
Regulation of Cell Growth by the EGF Receptor....Pages 58-64
Mutational Analysis of v-erbB Oncogene Function....Pages 65-69
The c-fms Proto-Oncogene and the CSF-1 Receptor....Pages 70-76
Activation of the c-src Gene....Pages 77-84
Transformation by the v-abl Oncogene....Pages 85-92
mos....Pages 93-99
Structure and Function of the Human Interleukin-2 Receptor....Pages 100-105
Front Matter....Pages 106-114
Phosphorylation in Signal Transmission and Transformation....Pages 115-120
Inositol Lipids and Cell Proliferation....Pages 121-127
Front Matter....Pages 128-134
Protein Kinase C....Pages 135-137
The Relevance of Protein Kinase C Activation, Glucose Transport and ATP Generation in the Response of Haemopoietic Cells to Growth Factors....Pages 138-146
Cytoplasmic pH and Free Ca2+ in the Action of Growth Factors....Pages 147-153
Epidermal Growth-Factor Mediation of S6 Phosphorylation During the Mitogenic Response: A Novel S6 Kinase....Pages 135-137
Role of G Proteins in Transmembrane Signaling: Possible Functional Homology with the ras Proteins....Pages 154-162
The ras Gene Family....Pages 163-169
Front Matter....Pages 170-176
Regulation of Human Globin Gene Expression....Pages 177-183
Regulation of Gene Expression by Steroid Hormones....Pages 184-191
Enhancers as Control Elements for Tissue-Specific Transcription....Pages 192-199
The Effect of DNA Methylation on DNA-Protein Interactions and on the Regulation of Gene Expression....Pages 200-208
Transactivator Genes of HTLV-I, II, and III....Pages 209-210
Involvement of Proto-Oncogenes in Growth Control: The Induction of c-fos and c-myc by Growth Factors....Pages 211-218
Oncogenes and Interferons: Genetic Targets for Animal Cell Growth Factors....Pages 219-226
Regulation of c-myc Expression in Normal and Transformed Mammalian Cells....Pages 226-234
Properties of the myc and myb Gene Products....Pages 235-240
The fos Oncogene and Transformation....Pages 241-246
p53: Molecular Properties and Biological Activities....Pages 247-252
Front Matter....Pages 253-258
Oncogene Cooperativity in Stepwise Transformation of Rodent Embryo Fibroblasts by Polyoma Virus....Pages 259-263
Front Matter....Pages 264-270
Oncogenes Cooperate, but How?....Pages 271-277
Individual and Combined Effects of Viral Oncogenes in Hematopoietic Cells....Pages 278-283
Multiple Factors Involved in B-Cell Tumorigenesis....Pages 284-289
Molecular Events Associated with Tumor Initiation, Promotion, and Progression in Mouse Skin....Pages 291-293
Amplification of Proto-Oncogenes and Tumor Progression....Pages 294-297
Suppression of the Neoplastic Phenotype....Pages 291-293
Front Matter....Pages 298-303
Oncogenesis in Transgenic Mice....Pages 304-311
Back Matter....Pages 312-319
....Pages 320-325