Ebook: Platelet Membrane Glycoproteins
Author: Ernst F. Lüscher (auth.) James N. George M.D. Alan T. Nurden Ph.D. David R. Phillips Ph.D. (eds.)
- Tags: Biochemistry general
- Year: 1985
- Publisher: Springer US
- Edition: 1
- Language: English
- pdf
It was just about ten years ago that platelet membrane glycoproteins were first charac terized and their abnormalities in congenital bleeding disorders first recognized. Dur ing this decade there has been a remarkable growth in our understanding of the structure and membrane organization of the platelet surface glycoproteins, their in teractions with external ligands during the process of hemostasis, and their defects causing hemorrhagic disease. These studies have advanced the knowledge of platelet involvement in hemostasis from a cellular to a molecular level, and they have provided a model for contact interactions among other cell types. This seemed a proper time to ask those who contributed major observations and insights during these past years to review their progress and to assess the state of our present knowledge. We have planned this volume to begin with the biochemistry of platelet membrane glycoproteins themselves and proceed through their involvement in platelet function to the final considerations of the platelet's role in maintaining the integrity of the vascular system. Our aim was an integrated presentation on the blood platelet from the perspective of its highly specialized and reactive cell surface. James N. George Alan T. Nurden David R. Phillips vii Contents I. INTRODUCTION 1. Plasma Membrane Receptors and Platelet Response Ernst F. Wscher 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. Platelet Receptor Functions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 . . . . . . . . . . 2. 1. Receptors Involved in Platelet Adhesion and in Cell-Cell Contact. . . 5 2. 2. Receptors Involved in Platelet Activation. . . . . . . . . . . . . . . . . . . 6 . . . . 3. Conclusion. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 II.
Content:
Front Matter....Pages i-xix
Front Matter....Pages 1-1
Plasma Membrane Receptors and Platelet Response....Pages 3-9
Front Matter....Pages 11-11
Structural and Molecular Properties of Platelet Membrane Systems....Pages 13-49
Glycoproteins of the Platelet Plasma Membrane....Pages 51-85
Organization of Glycoproteins within the Platelet Plasma Membrane....Pages 87-103
Structure and Function of Platelet Membrane Glycoproteins as Studied by Crossed Immunoelectrophoresis....Pages 105-127
Platelet Membrane Electrical Potential....Pages 129-141
Front Matter....Pages 143-143
Receptors for Platelet Agonists....Pages 145-169
Secreted Alpha Granule Proteins....Pages 171-191
The Platelet—Fibrinogen Interaction....Pages 193-214
Platelet—von Willebrand Factor Interactions....Pages 215-244
Molecular Mechanisms of Platelet Adhesion and Platelet Aggregation....Pages 245-257
Lectin—Carbohydrate Binding as a Model for Platelet Contact Interactions....Pages 259-270
Front Matter....Pages 271-271
The Organization of Platelet Contractile Proteins....Pages 273-298
The Mechanism of Clot Retraction....Pages 299-323
Front Matter....Pages 325-325
Immunology of the Platelet Surface....Pages 327-355
Glycoprotein Defects Responsible for Abnormal Platelet Function in Inherited Platelet Disorders....Pages 357-392
Front Matter....Pages 393-393
The Role of Membrane Glycoproteins in Platelet Formation, Circulation, and Senescence....Pages 395-412
Back Matter....Pages 413-419
Content:
Front Matter....Pages i-xix
Front Matter....Pages 1-1
Plasma Membrane Receptors and Platelet Response....Pages 3-9
Front Matter....Pages 11-11
Structural and Molecular Properties of Platelet Membrane Systems....Pages 13-49
Glycoproteins of the Platelet Plasma Membrane....Pages 51-85
Organization of Glycoproteins within the Platelet Plasma Membrane....Pages 87-103
Structure and Function of Platelet Membrane Glycoproteins as Studied by Crossed Immunoelectrophoresis....Pages 105-127
Platelet Membrane Electrical Potential....Pages 129-141
Front Matter....Pages 143-143
Receptors for Platelet Agonists....Pages 145-169
Secreted Alpha Granule Proteins....Pages 171-191
The Platelet—Fibrinogen Interaction....Pages 193-214
Platelet—von Willebrand Factor Interactions....Pages 215-244
Molecular Mechanisms of Platelet Adhesion and Platelet Aggregation....Pages 245-257
Lectin—Carbohydrate Binding as a Model for Platelet Contact Interactions....Pages 259-270
Front Matter....Pages 271-271
The Organization of Platelet Contractile Proteins....Pages 273-298
The Mechanism of Clot Retraction....Pages 299-323
Front Matter....Pages 325-325
Immunology of the Platelet Surface....Pages 327-355
Glycoprotein Defects Responsible for Abnormal Platelet Function in Inherited Platelet Disorders....Pages 357-392
Front Matter....Pages 393-393
The Role of Membrane Glycoproteins in Platelet Formation, Circulation, and Senescence....Pages 395-412
Back Matter....Pages 413-419
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