Ebook: The Diabetic Pancreas

Since the publication of the first edition of The Diabetic Pancreas in 1977, much progress has been made in various areas of diabetes research. While only a rela­ tively short while ago diabetes was considered a single disease, in more recent years it has become apparent that it is a heterogeneous group of disorders, all of which are characterized by a decreased tolerance of carbohydrates and most of which have a genetic basis, although the genetic types vary. In more recent years, an International Work Group sponsored by the National Diabetes Data Group of the NIH proposed a now generally accepted classification, according to which the insulin-dependent ketosis-prone diabetes, formerly and inappropriately called the juvenile type, is considered a subclass of diabetes, type 1. Because it can occur at any age, it was recommended that the diagnosis based on age be eliminated. The non-insulin-dependent, non-keto sis-prone type of diabetes, which is not secondary to other diseases or conditions, and which was formerly called matu­ rity-onset diabetes, was considered a second subclass, type II, because although this form usually develops after age 40, it also occurs in young persons, who do not require insulin or are not ketotic. Although this classification is not entirely agreed upon by all diabetologists, for practical purposes it has been generally accepted and has been utilized by the contributors to this volume.

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Content:
Front Matter....Pages i-xxiv
Historical Review....Pages 1-16
Comparative Morphology of Pancreatic Islets in Animals....Pages 17-52
Growth Pattern of Pancreatic Islets in Animals....Pages 53-79
Histology, Cell Types, and Functional Correlation of Islets of Langerhans....Pages 81-106
The PP Cell....Pages 107-115
Quantitative Studies of the Islets of Nondiabetic Patients....Pages 117-125
Histochemistry and Electron Microscopy of Islets....Pages 127-169
Morphology of Membrane Systems in Pancreatic Islets....Pages 171-212
Regulation and Role of Intracellular Ca2+ in Insulin Secretion by the ? Cell....Pages 213-231
Type II (Idiopathic) Diabetes (Non-Insulin-Dependent)....Pages 233-263
Pathogenetic Considerations of Type II Diabetes....Pages 265-273
Hormonal Diabetes Secondary to Extrapancreatic Endocrinopathies....Pages 275-297
Pancreatitis, Pancreatic Lithiasis, and Diabetes Mellitus....Pages 299-318
Cancer and Diabetes....Pages 319-325
Hemochromatosis and Diabetes....Pages 327-336
The Pathology of Type I (Juvenile) Diabetes....Pages 337-365
The Islets of Infants of Diabetic Mothers....Pages 367-384
Spontaneous Diabetes in Animals....Pages 385-413
Chemically and Hormonally Induced Diabetes Mellitus....Pages 415-438
Viral Diabetes....Pages 439-466
Experimental Insulitis....Pages 467-492
Immunology of Islet Cells....Pages 493-512
Islet Cell Transplantation....Pages 513-542
Endocrine Tumors of the Pancreas....Pages 543-586
Islet Cell Tumors and the Ulcerogenic Syndrome....Pages 587-615
Back Matter....Pages 617-628

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Content:
Front Matter....Pages i-xxiv
Historical Review....Pages 1-16
Comparative Morphology of Pancreatic Islets in Animals....Pages 17-52
Growth Pattern of Pancreatic Islets in Animals....Pages 53-79
Histology, Cell Types, and Functional Correlation of Islets of Langerhans....Pages 81-106
The PP Cell....Pages 107-115
Quantitative Studies of the Islets of Nondiabetic Patients....Pages 117-125
Histochemistry and Electron Microscopy of Islets....Pages 127-169
Morphology of Membrane Systems in Pancreatic Islets....Pages 171-212
Regulation and Role of Intracellular Ca2+ in Insulin Secretion by the ? Cell....Pages 213-231
Type II (Idiopathic) Diabetes (Non-Insulin-Dependent)....Pages 233-263
Pathogenetic Considerations of Type II Diabetes....Pages 265-273
Hormonal Diabetes Secondary to Extrapancreatic Endocrinopathies....Pages 275-297
Pancreatitis, Pancreatic Lithiasis, and Diabetes Mellitus....Pages 299-318
Cancer and Diabetes....Pages 319-325
Hemochromatosis and Diabetes....Pages 327-336
The Pathology of Type I (Juvenile) Diabetes....Pages 337-365
The Islets of Infants of Diabetic Mothers....Pages 367-384
Spontaneous Diabetes in Animals....Pages 385-413
Chemically and Hormonally Induced Diabetes Mellitus....Pages 415-438
Viral Diabetes....Pages 439-466
Experimental Insulitis....Pages 467-492
Immunology of Islet Cells....Pages 493-512
Islet Cell Transplantation....Pages 513-542
Endocrine Tumors of the Pancreas....Pages 543-586
Islet Cell Tumors and the Ulcerogenic Syndrome....Pages 587-615
Back Matter....Pages 617-628
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