Ebook: Molecular Biology of DNA Methylation
- Tags: Cell Biology, Biochemistry general, Plant Sciences, Virology, Microbiology
- Series: Springer Series in Molecular Biology
- Year: 1985
- Publisher: Springer-Verlag New York
- Edition: 1
- Language: English
- pdf
During the past few decades we have witnessed an era of remarkable growth in the field of molecular biology. In 1950 very little was known of the chemical constitution of biological systems, the manner in which in formation was transmitted from one organism to another, or the extent to which the chemical basis of life is unified. The picture today is dramati cally different. We have an almost bewildering variety of information detailing many different aspects of life at the molecular level. These great advances have brought with them some breath-taking insights into the molecular mechanisms used by nature for replicating, distributing and modifying biological information. We have learned a great deal about the chemical and physical nature of the macromolecular nucleic acids and proteins, and the manner in which carbohydrates, lipids and smaller mole cules work together to provide the molecular setting of living systems. It might be said that these few decades have replaced a near vacuum of information with a very large surplus. It is in the context of this flood of information that this series of mono graphs on molecular biology has been organized. The idea is to bring together in one place, between the covers of one book, a concise assess ment of the state of the subject in a well-defined field.
Content:
Front Matter....Pages i-xiv
Introduction....Pages 1-8
DNA Methylation in the Cell....Pages 9-18
DNA Structure and the Effect of Methylation....Pages 19-29
S-Adenosyl-L-methionine—Donor of Methyl Groups....Pages 31-41
The Methylation Machinery: DNA Methyltransferases....Pages 43-71
The Function of DNA Methylation in Bacteria and Phage....Pages 73-87
Methylation in Higher Eukaryotes....Pages 89-114
Methylation and Its Relationship with Transcription....Pages 115-161
X-Chromosome Inactivation....Pages 163-169
DNA Methylation and Cancer....Pages 171-174
Variations on a Theme: Patterns of Methylation in Protista, Fungi, Plants, and Animals....Pages 175-190
Has DNA a Role in the Control of Transcription?....Pages 191-200
Other Possible Functions of Eukaryotic DNA Methylation....Pages 201-206
DNA Methylation in Perspective—A Summing Up....Pages 207-210
Back Matter....Pages 211-247
Content:
Front Matter....Pages i-xiv
Introduction....Pages 1-8
DNA Methylation in the Cell....Pages 9-18
DNA Structure and the Effect of Methylation....Pages 19-29
S-Adenosyl-L-methionine—Donor of Methyl Groups....Pages 31-41
The Methylation Machinery: DNA Methyltransferases....Pages 43-71
The Function of DNA Methylation in Bacteria and Phage....Pages 73-87
Methylation in Higher Eukaryotes....Pages 89-114
Methylation and Its Relationship with Transcription....Pages 115-161
X-Chromosome Inactivation....Pages 163-169
DNA Methylation and Cancer....Pages 171-174
Variations on a Theme: Patterns of Methylation in Protista, Fungi, Plants, and Animals....Pages 175-190
Has DNA a Role in the Control of Transcription?....Pages 191-200
Other Possible Functions of Eukaryotic DNA Methylation....Pages 201-206
DNA Methylation in Perspective—A Summing Up....Pages 207-210
Back Matter....Pages 211-247
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