Ebook: Host Defenses to Intracellular Pathogens

The subject matter of this volume was the basis for a confer­ ence held in Philadelphia in June, 1981, and is an important one in the contemporary area of how the host interacts with micro­ organisms. In conception, it grew out of a graduate course entitled, "The Infectious Process," which has been taught in the Department of Microbiology and Immunology at Temple University School of Medicine during the past twelve years. This course has explored the broad areas of mechanisms of microbial pathogenesis and host resistance by in-depth consideration of selected models of experimental infection and immunity, as well as the clinical literature. It is noteworthy that there is no adequate text for this material, as the subject matter naturally crosses a wide spectrum of traditional disciplinary lines, encompassing topics as diverse as the mechanisms of action of bacterial toxins, the role of complement and antibody in phagocytosis, and the importance of cross-reacting bacterial polysaccharide antigens in vaccine development. A major portion of the course has always considered "cellular immunity" as it applies to host defenses to intracellular pathogens. It is in this area that the necessity for amalgamation of information from different disciplines is most evident, for one must be intimately concerned with the interactions between the microbe and the phagocyte, both before and after specific immune recognition.

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Content:
Front Matter....Pages i-xv
Introduction and Historical Perspective....Pages 1-4
Oxygen Independent Microbicidal Mechanisms of Human Polymorphonuclear Leukocytes....Pages 5-17
Oxidative Metabolism of Leukocytes and Its Relationship to Bactericidal Activity....Pages 19-30
Some Paradoxes of Macrophage Function....Pages 31-50
Genetic Disorders of Granulocyte Function: What they Tell Us about Normal Mechanisms....Pages 51-59
Modulation of Effector Lymphokines....Pages 61-68
Stimulation of Host Resistance to Metastatic Tumors by Macrophage Activating Agents Encapsulated in Liposomes....Pages 69-75
Effect of Prostaglandins on the Production of Interleukin-2....Pages 77-82
Interaction of Mycobacteria with Normal and Immunologically Activated Alveolar Macrophages....Pages 83-98
Guinea Pig Alveolar Macrophages Probably Kill M. Tuberculosis H37Rv and H37Ra In Vivo by Producing Hydrogen Peroxide....Pages 99-104
Interferon and Host Defense Systems....Pages 105-119
Mediator Interactions Regulating Macrophage Secretion of Interleukin 1 and Interferon....Pages 121-126
Macrophage Oxygen-Dependent Killing of Intracellular Parasites: Toxoplasma and Leishmania....Pages 127-143
Immunologic Lesions During Toxoplasma Gondii Infection....Pages 145-150
Cellular Mechanisms of Anti-Mycobacterial Immunity....Pages 151-155
Host Response to Infection with Mycobacterium Bovis (BCG) in Mice: Genetic Study of Natural Resistance....Pages 157-182
Cell Mediated Lysis of Lymphocytes Expressing Bacterial Antigens....Pages 183-188
Improvement of Abnormal Lymphocyte Responses in “Atypical” Mycobacteriosis with Indomethacin....Pages 189-195
Immunoregulatory Defects in Leprosy....Pages 197-201
Cellular Mechanisms of Resistance to Listeria Monocytogenes....Pages 203-215
Natural Resistance to Listeria Monocytogenes as a Function of Macrophage Inflammatory Response....Pages 217-225
Effect of Acute Nutritional Deprivation on Host Defenses Against Listeria Monocytogenes — Macrophage Function....Pages 227-233
Pilus-Mediated Clearance of Salmonella Typhimurium by the Perfused Mouse Liver....Pages 235-244
Immunity to Salmonella Infection....Pages 245-250
Strain Dependent Variation of Delayed-Type Hypersensitivity in Salmonella Typhimurium Infected Mice....Pages 251-259
Monoclonal Antibodies to Salmonella Typhimurium and Escherichia Coli Lipopolysaccharides....Pages 261-296
Activation of Macrophages for Killing of Rickettsiae: Analysis of Macrophage Effector Function after Rickettsial Inoculation of Inbred Mouse Strains....Pages 297-302
Parameters of Cellular Immunity in Acute and Chronic Rickettsia Tsutsugamushi Infections of Inbred Mice....Pages 303-311
Lymphokine Stimulated Macrophages Inhibit Intracellular Chlamydia Psittaci Replication by Mechanisms Distinct from Intracellular Inhibition of Toxoplasma Gondii Replication....Pages 313-317
Immunity to Fungal Infections....Pages 319-326
Antibody-Independent Mechanisms in the Development of Acquired Immunity to Malaria....Pages 327-333
Intracellular Destruction of Leishmania Tropica by Macrophages Activated in Vivo with Mycobacterium Bovis Strain BCG....Pages 335-353
Virus-Immune T Cells and Monoclonal Antibodies in the Mouse Influenza Model....Pages 355-360
Escape from Immune Surveillance during Persistent Virus Infection....Pages 361-364
Influence of Viruses on Cells of the Immune Response System....Pages 365-382
Genetically Controlled Resistance to Viruses....Pages 383-408
Macrophage Oxidative Metabolism: A Defense Mechanism Against Virus Infection?....Pages 409-423
Interferon-Induced Augmentation of Natural Killer Cell Activity by Splenocytes from Leukemia Virus Immunosuppressed Mice....Pages 425-431
Immunological Comparison of Ocular Disease Induced by two Strains of Herpes Virus of Different Virulence....Pages 433-439
Cellular Processing of the Large Glycoprotein of Lacrosse Virus (Family Bunyaviridae); Implications for Virion Assembly and Host Defense....Pages 441-447
CMV and Renal Allograft Survival....Pages 449-461
Back Matter....Pages 463-474
....Pages 475-487