Ebook: Gene Regulation by Steroid Hormones

Within the last two decades endocrinological research has taken a definite tum toward biochemistry and molecular biology. This has resulted in a new discipline called' 'molecular endocrinology. " Studies on the mechanism of hormone action have continued to make headlines with fundamental discov­ eries in receptor action and gene regulation. Recently the insect endocrino­ logists have also begun to explore the molecular mechanism of steroid hor­ mone action taking advantage of the vast number of Drosophila mutants, the library of Drosophila gene, and several well-characterized cell-lines. The availability ofthe recombinant DNA technology has provided a truly revolu­ tionary tool in the hands of the molecular endocrinologists. "Gene Regula­ tion by Steroid Hormones" is compiled and presented in this frontier spirit, and we hope that this volume will serve not only the active investigators in the field but will also be very useful to students and researchers with a gen­ eral interest in regulatory biology. The book is an offshoot of the Conference on Molecular Mechanism of Steroid Hormone Action held at the Meadow Brook Mansion of Oakland University in the fall of 1978. We wish to acknowledge the financial assist­ ance from the National Science Foundation and Oakland University. The conferees will never forget the warmest hospitality of Dr. LOWELL EKLUND and his staff at the Meadow Brook center and we also wish to express per­ sonal gratitude to many of our students and colleagues for helping us to make the conference a great success.

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Content:
Front Matter....Pages I-XII
Front Matter....Pages 1-1
Steroid Hormone Action: Comments on the Nature of the Problem....Pages 2-4
The Structure and Regulation of the Natural Chicken Ovomucoid Gene....Pages 5-31
The Effect of Estrogen on Gene Expression in Avian Liver....Pages 32-57
Steroid-Hormone Modulation of Prolactin Action in the Rat Mammary Gland....Pages 58-77
Steroid Receptor Subunit Structure....Pages 78-88
Estrogen Receptor Heterogeneity and Uterotropic Response....Pages 89-105
Analysis of the Avian Progesterone Receptor with Inhibitors....Pages 106-119
Front Matter....Pages 121-121
Molecular Mechanisms of Glucocorticoid Action: An Historical Perspective....Pages 122-125
Multiple Actions of Glucocorticoids Studied in Cell Culture Systems....Pages 126-152
Studies on the Mechanism of Glucocorticoid Hormone Action....Pages 153-187
Front Matter....Pages 189-189
Enigmas in the Molecular Biology of Androgen Action....Pages 190-193
Receptors and Factors Regulating Androgen Action in the Rat Ventral Prostate....Pages 194-214
The Mechanism of Androgen and Progestin Action on Mouse Kidney....Pages 215-229
Hormone-Dependent Expression of ?2u Globulin Gene in Rat Liver....Pages 230-246
Front Matter....Pages 247-247
Ecdysone: Introduction to the Molecular Mechanism of Steroid Action in Insects....Pages 248-254
Hormonal Control of Gene Expression and Development by Ecdysone in Drosophila ....Pages 255-262
Ecdysteroid Receptors in Cultured Drosophila Cells....Pages 263-277
Ecdysteroid Hormone Effects on a Drosophila Cell Line....Pages 278-308
Back Matter....Pages 309-316

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Content:
Front Matter....Pages I-XII
Front Matter....Pages 1-1
Steroid Hormone Action: Comments on the Nature of the Problem....Pages 2-4
The Structure and Regulation of the Natural Chicken Ovomucoid Gene....Pages 5-31
The Effect of Estrogen on Gene Expression in Avian Liver....Pages 32-57
Steroid-Hormone Modulation of Prolactin Action in the Rat Mammary Gland....Pages 58-77
Steroid Receptor Subunit Structure....Pages 78-88
Estrogen Receptor Heterogeneity and Uterotropic Response....Pages 89-105
Analysis of the Avian Progesterone Receptor with Inhibitors....Pages 106-119
Front Matter....Pages 121-121
Molecular Mechanisms of Glucocorticoid Action: An Historical Perspective....Pages 122-125
Multiple Actions of Glucocorticoids Studied in Cell Culture Systems....Pages 126-152
Studies on the Mechanism of Glucocorticoid Hormone Action....Pages 153-187
Front Matter....Pages 189-189
Enigmas in the Molecular Biology of Androgen Action....Pages 190-193
Receptors and Factors Regulating Androgen Action in the Rat Ventral Prostate....Pages 194-214
The Mechanism of Androgen and Progestin Action on Mouse Kidney....Pages 215-229
Hormone-Dependent Expression of ?2u Globulin Gene in Rat Liver....Pages 230-246
Front Matter....Pages 247-247
Ecdysone: Introduction to the Molecular Mechanism of Steroid Action in Insects....Pages 248-254
Hormonal Control of Gene Expression and Development by Ecdysone in Drosophila ....Pages 255-262
Ecdysteroid Receptors in Cultured Drosophila Cells....Pages 263-277
Ecdysteroid Hormone Effects on a Drosophila Cell Line....Pages 278-308
Back Matter....Pages 309-316
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