Ebook: Steroid Hormone Receptor Systems

The papers in this volume were presented at the Symposium on Steroid Hormone Receptor Systems held October 18-20, 1978, at the Worcester Foundation for Experimental Biology, Shrewsbury, Mass. The meeting was organized to review, discuss, and disseminate new knowledge about the regulation and function of the receptor proteins which mediate estrogen, progestin, glucocorticoid, and androgen action. The symposium brought together leading scientists whose interests span the spectrum of biological organization. On this occasion, Drs. Elwood V. Jensen and Etienne E. Baulieu were honored as recipients of the Tenth Annual Gregory Pincus l1emorial Award for their pioneering studies of steroid hormone receptors. The material covered in this book focuses on the molecular mechanisms which control receptor site availability and function. The topics discussed include recent work on receptor antibodies, antiestrogen action, receptor heterogeneity, nuclear binding and processing of receptor, receptor activation and inactivation mechan­ isms, interactions between receptor systems, influence of biological rhythms, membrane binding sites, and the evolution of steroid-bind­ ing proteins. Although studies on steroid receptors have led to the development of new approaches for cancer therapy and contraception, much remains to be discovered in this rapidly expanding field. Hope­ fully, this book will provide added impetus to the quest for a full understanding of steroid receptor systems by drawing attention to the unresolved questions yet to be answered. Hhile the book is intended primarily for those interested in hormone action, it should be of value to a more general audience including cell, molecular, and developmental biologists.

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Content:
Front Matter....Pages i-ix
The Immunoendocrinology of Estrophilin....Pages 1-16
Nuclear Binding of the Estrogen Receptor: Heterogeneity of Sites and Uterotropic Response....Pages 17-46
The Specific Binding of Estradiol to the Nuclear Matrix....Pages 47-70
Heterogeneity of Nuclear Glucocorticoid Receptor Interactions....Pages 71-93
Estrogen Control of Progesterone Receptor Induction in Human Breast Cancer: Role of Nuclear Estrogen Receptor....Pages 95-110
Estrogen and Antiestrogen Action: Studies in Reproductive Target Tissues and Tumors....Pages 111-132
Inhibition of Cell Division and Stimulation of Progesterone Receptor Synthesis in Rat Oestrogen Target Tissues by Non-Steroidal Antioestrogens....Pages 133-155
Steroid Hormone Regulation of Uterine Peroxidase Activity....Pages 157-171
Progesterone Suppression of the Estradiol Receptor in the Reproductive Tract of Macaques, Cats, and Hamsters....Pages 173-196
Regulation and Function of Estrogen and Progesterone Receptor Systems....Pages 197-222
Effects of Progestins on the Progesterone Receptor in Guinea Pig Uterus....Pages 223-239
The Use of Medroxyprogesterone Acetate to Study Progestin Receptors in Immature, Pregnant, and Adult Rabbit Uterus....Pages 241-254
Circannual Rhythms in Progesterone Receptor Levels and Functions....Pages 255-268
In Vivo Metabolism and Binding of 6?-Methylprogesterone; A Progestin with Anti-Androgenic and Synandrogenic Activities....Pages 269-280
Factors Regulating the Androgenic Action of Progestins in Mouse Kidney....Pages 281-295
The Role of Ligand-Binding as a Determinant of the Structure and Activation of the Estrogen Receptor....Pages 297-307
Structural Relationships between the Chick Oviduct Progesterone Receptor A and B Proteins....Pages 309-327
Characterization of the Avian Progesterone Receptor Through the Use of Inhibitors....Pages 329-341
Glucocorticoid Receptor Inactivation and Activation by Phosphorylation Mechanisms....Pages 343-356
Glucocorticoid Receptor Cleavage by Leupeptin-Sensitive Enzymes in Rat Kidney Cytosol....Pages 357-375
Aspects of Steroid Hormone-Target Cell Interactions....Pages 377-399
Studies on the Mechanism of Estradiol Uptake by Rat Uterine Cells and on Estradiol Binding to Uterine Plasma Membranes....Pages 401-421
Heterogeneity of AtT-20 Cell Glucocorticoid Binding Sites: Evidence for a Membrane Receptor....Pages 423-440
Sex Steroid Binding Proteins in Non-Mammalian Vertebrates....Pages 441-459
The Ovalbumin Gene: Transcriptional Regulation by Estrogen....Pages 461-485
Back Matter....Pages 487-489

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Content:
Front Matter....Pages i-ix
The Immunoendocrinology of Estrophilin....Pages 1-16
Nuclear Binding of the Estrogen Receptor: Heterogeneity of Sites and Uterotropic Response....Pages 17-46
The Specific Binding of Estradiol to the Nuclear Matrix....Pages 47-70
Heterogeneity of Nuclear Glucocorticoid Receptor Interactions....Pages 71-93
Estrogen Control of Progesterone Receptor Induction in Human Breast Cancer: Role of Nuclear Estrogen Receptor....Pages 95-110
Estrogen and Antiestrogen Action: Studies in Reproductive Target Tissues and Tumors....Pages 111-132
Inhibition of Cell Division and Stimulation of Progesterone Receptor Synthesis in Rat Oestrogen Target Tissues by Non-Steroidal Antioestrogens....Pages 133-155
Steroid Hormone Regulation of Uterine Peroxidase Activity....Pages 157-171
Progesterone Suppression of the Estradiol Receptor in the Reproductive Tract of Macaques, Cats, and Hamsters....Pages 173-196
Regulation and Function of Estrogen and Progesterone Receptor Systems....Pages 197-222
Effects of Progestins on the Progesterone Receptor in Guinea Pig Uterus....Pages 223-239
The Use of Medroxyprogesterone Acetate to Study Progestin Receptors in Immature, Pregnant, and Adult Rabbit Uterus....Pages 241-254
Circannual Rhythms in Progesterone Receptor Levels and Functions....Pages 255-268
In Vivo Metabolism and Binding of 6?-Methylprogesterone; A Progestin with Anti-Androgenic and Synandrogenic Activities....Pages 269-280
Factors Regulating the Androgenic Action of Progestins in Mouse Kidney....Pages 281-295
The Role of Ligand-Binding as a Determinant of the Structure and Activation of the Estrogen Receptor....Pages 297-307
Structural Relationships between the Chick Oviduct Progesterone Receptor A and B Proteins....Pages 309-327
Characterization of the Avian Progesterone Receptor Through the Use of Inhibitors....Pages 329-341
Glucocorticoid Receptor Inactivation and Activation by Phosphorylation Mechanisms....Pages 343-356
Glucocorticoid Receptor Cleavage by Leupeptin-Sensitive Enzymes in Rat Kidney Cytosol....Pages 357-375
Aspects of Steroid Hormone-Target Cell Interactions....Pages 377-399
Studies on the Mechanism of Estradiol Uptake by Rat Uterine Cells and on Estradiol Binding to Uterine Plasma Membranes....Pages 401-421
Heterogeneity of AtT-20 Cell Glucocorticoid Binding Sites: Evidence for a Membrane Receptor....Pages 423-440
Sex Steroid Binding Proteins in Non-Mammalian Vertebrates....Pages 441-459
The Ovalbumin Gene: Transcriptional Regulation by Estrogen....Pages 461-485
Back Matter....Pages 487-489
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