Ebook: Mechanism of Action of Antieukaryotic and Antiviral Compounds

When Antibiotics I was published in 1967, the teleological view was held by some that" antibiotics" were substances elaborated by certain microorgan­ isms for the purpose of competing with other microorganisms for survival in mixed ecological environments. However, not only had J. EHRLICH and his associates shown 15 years earlier that chloramphenicol was produced by Strepto­ myces venezuelae in cultures of sterilized soils but not in parallel cultures of the same soils which were not sterilized, but operationally, the search for anti­ cancer antibiotics was actively under way (Antibiotics I reporting on numerous such substances), although the concept of antibiosis could not logically justify such undertakings. This editor hesitates to accept the use of the term "antibiotic" for anti­ microbial agents of non microbiological origins which is sometimes encountered, but neither does he subscribe to the view that antibiotics are in some fundamental manner different from chemotherapeutic substances of other origins. Modes and mechanisms of action of chemotherapeutic compounds are not systematic functions of their origins nor of the taxonomical position of the target organisms. Consequently, in the selection of topics for Antibiotics III (published in 1975), synthetic drugs and natural products of higher plants (alkaloids) were represented, along with antibiotics in the strict sense of the definition. We now present Antibiotics V, for whose assembly the same selection criteria were applied as for Antibiotics Ill. The aggregate length of the contributions rendered it impractical to place the entire text between the covers of one book.

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Content:
Front Matter....Pages I-XIII
Anisomycin and Related Antibiotics....Pages 1-19
Antitumor Platinum Compounds....Pages 20-84
9-?-D-Arabinofuranosyladenine (AraA)....Pages 85-109
8-Azaguanine....Pages 110-123
Bleomycin....Pages 124-154
Echinomycin, Triostin, and Related Antibiotics....Pages 155-172
Ellipticine....Pages 173-194
2-Hydroxy-3-Alkyl-1,4-Naphthoquinones....Pages 195-213
Hydroxystilbamidine....Pages 214-222
5-Iodo-2?-Deoxyuridine....Pages 223-235
Neocarzinostatin....Pages 236-261
Nitracrine....Pages 262-274
Phleomycin....Pages 275-297
Polyene Antibiotics: Nystatin, Amphotericin B, and Filipin....Pages 298-312
Protein and Glycoprotein Toxins That Inactivate the Eukaryotic Ribosome....Pages 313-340
Quinine....Pages 341-352
Showdomycin....Pages 353-362
Streptonigrin....Pages 363-371
Tilorone Hydrochloride....Pages 372-384
The Vinca Alkaloids....Pages 385-413
Virazole (Ribavirin)....Pages 414-438
Back Matter....Pages 439-458
....Pages 459-472