Ebook: Mechanism of Action of Antimicrobial and Antitumor Agents
- Tags: Life Sciences general, Biomedicine general
- Series: Antibiotics 3
- Year: 1975
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
This volume is the third in the series devoted to Antibiotics initiated by Springer Verlag in 1967. The first two volumes were devoted to the Mode of Action of Antibiotics and Biogenesis, respectively and were received graciously. During the intervening years these two works have been used often by research workers and students alike and have been quoted extensively. Although a number of other excellent treatises on antibiotics have appeared, the Springer series has set a standard for thoroughness and quality that meets the need of the scientific community. It is against this background that the present Editors set about the preparation of a third volume in the Series on Antibiotics. Since the appearance of Volume I, also dealing with Mechanism of Action, tremendous strides have been made in the depth and breadth of our knowledge of molecular biology, microbial chemistry and molecular pharmacology and of their direct application to studies on the mode of action of drugs. The field of molecular biology itself was in its relative infancy during the preceding decade and the unique role played by many anti biotics in the development of our understanding of nucleic acid synthesis and function and its relationship to protein synthesis and cell physiology has led rapidly to a very precise, understanding of how many of these same antibiotics inhibit susceptible cells.
Content:
Front Matter....Pages I-XII
Front Matter....Pages 1-1
Anthramycin....Pages 3-11
3?-Amino-3?-Deoxyadenosine....Pages 12-20
Bleomycin....Pages 21-33
Berenil: A Trypanocide with Selective Activity against Extranuclear DNA....Pages 34-47
Camptothecin....Pages 48-57
Chloroquine (Resochin)....Pages 58-78
Distamycin A and Netropsin....Pages 79-100
Daunomycin (Daunorubicin) and Adriamycin and Structural Analogues: Biological Activity and Mechanism of Action....Pages 101-128
Edeines....Pages 129-140
Ethidium and Propidium....Pages 141-165
Kanchanomycin....Pages 166-173
Nalidixic Acid—Mode of Action....Pages 174-196
Olivomycin, Chromomycin, and Mithramycin....Pages 197-202
Quinacrine and Other Acridines....Pages 203-233
Quinoxaline Antibiotics....Pages 234-251
Rifamycins and Other Ansamycins....Pages 252-268
Sibiromycin....Pages 269-273
Thiaxanthenones: Miracil D and Hycanthone....Pages 274-302
Addendum....Pages 302-303
Trimethoprim and Pyrimethamine....Pages 304-320
Front Matter....Pages 321-321
Althiomycin....Pages 323-326
Aurintricarboxylic Acid a Non-Antibiotic Organic Molecule that Inhibits Protein Synthesis....Pages 327-339
Aminoglycoside Antibiotics....Pages 340-364
Borrelidin....Pages 365-369
Chloramphenicol....Pages 370-395
The Erythromycins....Pages 396-419
Emetine and Related Alkaloids....Pages 420-435
Fusidic Acid....Pages 436-447
Gougerotin....Pages 448-458
The Macrolide Antibiotics....Pages 459-479
Micrococcin and Micrococcin P....Pages 480-486
Mikamycin....Pages 487-497
Pactamycin....Pages 498-515
Primaquine....Pages 516-520
The Streptogramin Family of Antibiotics....Pages 521-534
Streptomycin, Dihydrostreptomycin, and the Gentamicins....Pages 535-550
The Thiostrepton Group of Antibiotics....Pages 551-573
Front Matter....Pages 575-575
Berberine....Pages 577-584
Boromycin....Pages 585-587
Colicins 1972....Pages 588-605
Front Matter....Pages 575-575
Griseofulvin....Pages 606-613
Irehdiamine and Malouetine....Pages 614-622
Isonicotinic Acid Hydrazide....Pages 623-652
Sideromycins....Pages 653-667
Sulfonamides and Sulfones....Pages 668-698
Suramin....Pages 699-703
Vancomycin....Pages 704-718
Back Matter....Pages 719-744
Content:
Front Matter....Pages I-XII
Front Matter....Pages 1-1
Anthramycin....Pages 3-11
3?-Amino-3?-Deoxyadenosine....Pages 12-20
Bleomycin....Pages 21-33
Berenil: A Trypanocide with Selective Activity against Extranuclear DNA....Pages 34-47
Camptothecin....Pages 48-57
Chloroquine (Resochin)....Pages 58-78
Distamycin A and Netropsin....Pages 79-100
Daunomycin (Daunorubicin) and Adriamycin and Structural Analogues: Biological Activity and Mechanism of Action....Pages 101-128
Edeines....Pages 129-140
Ethidium and Propidium....Pages 141-165
Kanchanomycin....Pages 166-173
Nalidixic Acid—Mode of Action....Pages 174-196
Olivomycin, Chromomycin, and Mithramycin....Pages 197-202
Quinacrine and Other Acridines....Pages 203-233
Quinoxaline Antibiotics....Pages 234-251
Rifamycins and Other Ansamycins....Pages 252-268
Sibiromycin....Pages 269-273
Thiaxanthenones: Miracil D and Hycanthone....Pages 274-302
Addendum....Pages 302-303
Trimethoprim and Pyrimethamine....Pages 304-320
Front Matter....Pages 321-321
Althiomycin....Pages 323-326
Aurintricarboxylic Acid a Non-Antibiotic Organic Molecule that Inhibits Protein Synthesis....Pages 327-339
Aminoglycoside Antibiotics....Pages 340-364
Borrelidin....Pages 365-369
Chloramphenicol....Pages 370-395
The Erythromycins....Pages 396-419
Emetine and Related Alkaloids....Pages 420-435
Fusidic Acid....Pages 436-447
Gougerotin....Pages 448-458
The Macrolide Antibiotics....Pages 459-479
Micrococcin and Micrococcin P....Pages 480-486
Mikamycin....Pages 487-497
Pactamycin....Pages 498-515
Primaquine....Pages 516-520
The Streptogramin Family of Antibiotics....Pages 521-534
Streptomycin, Dihydrostreptomycin, and the Gentamicins....Pages 535-550
The Thiostrepton Group of Antibiotics....Pages 551-573
Front Matter....Pages 575-575
Berberine....Pages 577-584
Boromycin....Pages 585-587
Colicins 1972....Pages 588-605
Front Matter....Pages 575-575
Griseofulvin....Pages 606-613
Irehdiamine and Malouetine....Pages 614-622
Isonicotinic Acid Hydrazide....Pages 623-652
Sideromycins....Pages 653-667
Sulfonamides and Sulfones....Pages 668-698
Suramin....Pages 699-703
Vancomycin....Pages 704-718
Back Matter....Pages 719-744
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