Ebook: Hormones and Resistance: Part 1 and Part 2

7 If so, the individual members of each class thus identified could then be subjected to a more profound pharmacokinetic analysis. In other words, we had to determine first which hormone protects against which drug, before we could explore how it did this. We had to know first that a hormone has adaptive value before we could ask whether this is due to a syntoxic or a catatoxic mechanism. Such observations, as the fact that an indomethacin-induced intestinal ulcer can be prevented by ethylestrenol, orthat cortisol aggravates certain infections, reveal nothing about how these hormones work; but only findings of this type can tell us where further research would be rewarding. Of course, scientists can rarely identify by direct observation the tbings that they are looking for; most of the time they have to be guided by indirect indices. The ebernist often first detects a compound, or even a particular functional group in its molecule, by inference from a color reaction, a revealing X-ray diffraction pattern or the formation of a characteristic precipitate. The physician must first suspect the presence of a microbe through certain clinical signs and symptoms before he can verify his diagnosis by looking for a particular organism. It is perhaps not too daring to hope that in our first efforts to clarify the role of hormones in resistance, simple, directly visible indicators might also serve us best.

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Content:
Front Matter....Pages I-XVIII
Reviews....Pages 1-4
Introduction, Terminology and Classification, Methods....Pages 5-23
History....Pages 24-41
Chemistry....Pages 42-52
General Pharmacology....Pages 53-110
Effect of Steroids Upon Resistance....Pages 111-404
Effect of Other Hormones Upon Resistance....Pages 405-565
Effect of Nonhormonal Factors Upon Resistance....Pages 567-706
Clinical Implications....Pages 707-724
Morphology....Pages 725-742
Theories....Pages 743-767
Synopsis of Pharmaco-Chemical and Pharmaco-Pharmacologic Interrelations....Pages 768-1051
Back Matter....Pages 1053-1140

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Content:
Front Matter....Pages I-XVIII
Reviews....Pages 1-4
Introduction, Terminology and Classification, Methods....Pages 5-23
History....Pages 24-41
Chemistry....Pages 42-52
General Pharmacology....Pages 53-110
Effect of Steroids Upon Resistance....Pages 111-404
Effect of Other Hormones Upon Resistance....Pages 405-565
Effect of Nonhormonal Factors Upon Resistance....Pages 567-706
Clinical Implications....Pages 707-724
Morphology....Pages 725-742
Theories....Pages 743-767
Synopsis of Pharmaco-Chemical and Pharmaco-Pharmacologic Interrelations....Pages 768-1051
Back Matter....Pages 1053-1140
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