Ebook: Mechanism of Action

The idea for publishing these books on the mechanism of action and on the biosynthesis of antibiotics was born of frustration in our attempts to keep abreast of the literature. Gone were the years when we were able to keep a biblio­ graphy on antibiotics and feel confident that we could find everything that was being published on this subject. These fields of investigation were moving for­ ward so rapidly and were encompassing so wide a range of specialized areas in microbiology and chemistry that it was almost impossible to keep abreast of developments. In our naivete and enthusiasm, however, we were unaware that we were toying with an idea that might enmesh us, that we were creating an entity with a life of its own, that we were letting loose a Golom who instead of being our servant would be our master. That we set up ideals for these books is obvious; they would be current guides to developments and information in the areas of mechanism of action and bio­ synthesis of antibiotics. For almost every subject, we wished to enlist the aid of an investigator who himself had played a part in determining the nature of the phenomena that were being discussed. One concept for the books was that they include only antibiotics for which a definitive, well-documented mechanism of action or biosynthetic pathway was known.

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Content:
Front Matter....Pages I-XII
Penicillins and Cephalosporins....Pages 1-19
Penicillins and Cephalosporins....Pages 20-39
Ristocetin....Pages 40-83
Bacitracin....Pages 84-89
Vancomycin....Pages 90-101
Pyocyanine....Pages 102-116
Polyene Antibiotics....Pages 117-121
Polymyxins and Circulin....Pages 122-141
Albomycin....Pages 142-152
Sarkomycin....Pages 153-155
Pluramycin....Pages 156-165
Edeine and Pactamycin....Pages 166-168
Phleomycin, Xanthomycin, Streptonigrin, Nogalamycin, and Aurantin....Pages 169-172
Griseofulvin....Pages 173-180
Daunomycin and Related Antibiotics....Pages 181-189
The Mitomycins and Porfiromycins....Pages 190-210
Chromomycin, Olivomycin and Mithramycin....Pages 211-245
Puromycin....Pages 246-258
Gougerotin....Pages 259-277
Cycloheximide and Other Glutarimide Antibiotics....Pages 278-282
Chloramphenicol....Pages 283-307
Tetracyclines....Pages 308-330
Tenuazonic Acid....Pages 331-359
Macrolide antibiotics — Spiramycin, Carbomycin, Angolamycin, Methymycin and Lancamycin....Pages 360-365
Erythromycin and Oleandomycin....Pages 366-377
The Streptogramin Family of Antibiotics....Pages 378-386
Fucidin....Pages 387-403
Sparsomycin....Pages 404-409
Rifamycins....Pages 410-414
Nucleocidin....Pages 415-426
Blasticidin S....Pages 427-433
Lincomycin....Pages 434-439
Chalcomycin....Pages 440-445
Hadacidin....Pages 446-450
Psicofuranine....Pages 451-456
Angustmycin A....Pages 457-463
Cordycepin....Pages 464-467
Azaserine and 6-Diazo-5-Oxo-L-Norleucine (DON)....Pages 468-480
Tubercidin and Related Pyrrolopyrimidine Antibiotics....Pages 481-493
Sideromycins....Pages 494-498
Antimycin A....Pages 499-541
Oligomycin Complex, Rutamycin and Aurovertin....Pages 542-584
Usnic Acid....Pages 585-610
Nigericin....Pages 611-612
Flavensomycin....Pages 613-616
Patulin....Pages 617-620
Valinomycin....Pages 621-630
Tyrocidines and Gramicidin S (J1, J2)....Pages 631-635
Gramicidins....Pages 636-641
Nonactin and Related Antibiotics....Pages 642-648
Novobiocin....Pages 649-650
Actithiazic Acid....Pages 651-665
Minomycin....Pages 666-668
Protoanemonin....Pages 669-670
Trichothecin....Pages 671-673
Viomycin....Pages 674-676
Actinomycetin....Pages 677-680
Bacteriocins....Pages 681-683
Megacins....Pages 684-687
Colicins....Pages 688-695
Enzymatic Reactions in Bacterial Cell Wall Synthesis Sensitive to Penicillins, Cephalosporins, and Other Antibacterial Agents....Pages 696-704
Actinomycin....Pages 705-713
The Effect of Streptomycin and Other Aminoglycoside Antibiotics on Protein Synthesis....Pages 714-725
Addenda....Pages 726-747
Back Matter....Pages 748-763
....Pages 764-785