Ebook: Computer and Information Science Applications in Bioprocess Engineering

Biotechnology has been labelled as one of the key technologies of the last two decades of the 20th Century, offering boundless solutions to problems ranging from food and agricultural production to pharmaceutical and medical applications, as well as environmental and bioremediation problems. Biological processes, however, are complex and the prevailing mechanisms are either unknown or poorly understood. This means that adequate techniques for data acquisition and analysis, leading to appropriate modeling and simulation packages that can be superimposed on the engineering principles, need to be routine tools for future biotechnologists. The present volume presents a masterly summary of the most recent work in the field, covering: instrumentation systems; enzyme technology; environmental biotechnology; food applications; and metabolic engineering.

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Biotechnology has been labelled as one of the key technologies of the last two decades of the 20th Century, offering boundless solutions to problems ranging from food and agricultural production to pharmaceutical and medical applications, as well as environmental and bioremediation problems. Biological processes, however, are complex and the prevailing mechanisms are either unknown or poorly understood. This means that adequate techniques for data acquisition and analysis, leading to appropriate modeling and simulation packages that can be superimposed on the engineering principles, need to be routine tools for future biotechnologists. The present volume presents a masterly summary of the most recent work in the field, covering: instrumentation systems; enzyme technology; environmental biotechnology; food applications; and metabolic engineering.

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Biotechnology has been labelled as one of the key technologies of the last two decades of the 20th Century, offering boundless solutions to problems ranging from food and agricultural production to pharmaceutical and medical applications, as well as environmental and bioremediation problems. Biological processes, however, are complex and the prevailing mechanisms are either unknown or poorly understood. This means that adequate techniques for data acquisition and analysis, leading to appropriate modeling and simulation packages that can be superimposed on the engineering principles, need to be routine tools for future biotechnologists. The present volume presents a masterly summary of the most recent work in the field, covering: instrumentation systems; enzyme technology; environmental biotechnology; food applications; and metabolic engineering.
Content:
Front Matter....Pages i-xvi
Front Matter....Pages 1-1
Computer-Based Studies on Bioprocess Engineering....Pages 3-26
Computer-Based Studies on Bioprocess Engineering....Pages 27-49
Multivariable Control of a Continuous Culture....Pages 51-57
Steady States in Continuous Culture....Pages 59-65
Introduction to Artificial Intelligence....Pages 67-75
Nonlinear Oscillations in Bioreaction Systems....Pages 77-82
Bioreactor Instrumentation and Biosensors....Pages 83-94
Bioreactors for Improved Process Performance....Pages 95-107
Bioreactor Fault Detection Using Data Reconciliation....Pages 109-114
The Design Approach of Multiproduct Plants....Pages 115-124
Strategies for Bioreactor Scale-Up....Pages 125-142
Statistical Design and Analysis of Experiments....Pages 143-156
Simulation of a Complex Biotechnological Process Using an Object-Oriented Knowledge-Based System....Pages 157-163
Front Matter....Pages 165-165
The Implication of pH on the Design of an Enzymatic Reactor for Penicillin Hydrolysis....Pages 167-177
Simulation of Batch Enzyme Reactors....Pages 179-189
Modeling of Membrane Bioreactors....Pages 191-200
Membrane Bioreactor with Immobilized Lipase: Modelling and Computational Considerations....Pages 201-220
Protein Extraction by Reversed Micellar Systems....Pages 221-235
Front Matter....Pages 237-237
Role of Cyanide on Polycyclic Aromatic Hydrocarbon Degradation in Manufactured Gas Plant Soils....Pages 239-243
Biomass Refining....Pages 245-252
Front Matter....Pages 237-237
Anaerobic Methane Fermentation in a Plug-Flow Reactor Treating Organic Wastes....Pages 253-263
Activated Sludge....Pages 265-270
Biotechnology and the Environment....Pages 271-278
Front Matter....Pages 279-279
An Efficient Computer Programme for the Simulation of Food Freezing Operations....Pages 281-289
Modelling and Simulation of Convective Green-Pea Drying....Pages 291-297
Front Matter....Pages 299-299
Modelling of the Baculovirus Infection Process in Insect-Cell Reactor Configurations....Pages 301-316
Use of Fed-Batch Operation to Improve Secondary Metabolite Production....Pages 317-323
Bioreactor Design for Animal Cell Cultures: With Special Reference to Mass Transfer....Pages 325-347
General Methodology in Bioprocess Engineering....Pages 349-364
Industrial Scale Antibiotic Production: Process Kinetic Analysis and Process Design....Pages 365-376
Oxygen Transfer and Microbial Growth....Pages 377-394
Classroom Adaptation of Escherichia Coli Single Cell Model....Pages 395-400
Kinetics of Continuous Microbial Culture: Plug-Flow, Chemostat, Turbidostat and Fed-Batch Principles....Pages 401-417
A Spreadsheet Simulation of a Differential Reactor for Estimating Kinetic Constants....Pages 419-433
Production of Fuel Alcohols by Fermentation: Engineering and Physiological Basis for Improving Processes....Pages 435-470
Back Matter....Pages 471-477

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Biotechnology has been labelled as one of the key technologies of the last two decades of the 20th Century, offering boundless solutions to problems ranging from food and agricultural production to pharmaceutical and medical applications, as well as environmental and bioremediation problems. Biological processes, however, are complex and the prevailing mechanisms are either unknown or poorly understood. This means that adequate techniques for data acquisition and analysis, leading to appropriate modeling and simulation packages that can be superimposed on the engineering principles, need to be routine tools for future biotechnologists. The present volume presents a masterly summary of the most recent work in the field, covering: instrumentation systems; enzyme technology; environmental biotechnology; food applications; and metabolic engineering.
Content:
Front Matter....Pages i-xvi
Front Matter....Pages 1-1
Computer-Based Studies on Bioprocess Engineering....Pages 3-26
Computer-Based Studies on Bioprocess Engineering....Pages 27-49
Multivariable Control of a Continuous Culture....Pages 51-57
Steady States in Continuous Culture....Pages 59-65
Introduction to Artificial Intelligence....Pages 67-75
Nonlinear Oscillations in Bioreaction Systems....Pages 77-82
Bioreactor Instrumentation and Biosensors....Pages 83-94
Bioreactors for Improved Process Performance....Pages 95-107
Bioreactor Fault Detection Using Data Reconciliation....Pages 109-114
The Design Approach of Multiproduct Plants....Pages 115-124
Strategies for Bioreactor Scale-Up....Pages 125-142
Statistical Design and Analysis of Experiments....Pages 143-156
Simulation of a Complex Biotechnological Process Using an Object-Oriented Knowledge-Based System....Pages 157-163
Front Matter....Pages 165-165
The Implication of pH on the Design of an Enzymatic Reactor for Penicillin Hydrolysis....Pages 167-177
Simulation of Batch Enzyme Reactors....Pages 179-189
Modeling of Membrane Bioreactors....Pages 191-200
Membrane Bioreactor with Immobilized Lipase: Modelling and Computational Considerations....Pages 201-220
Protein Extraction by Reversed Micellar Systems....Pages 221-235
Front Matter....Pages 237-237
Role of Cyanide on Polycyclic Aromatic Hydrocarbon Degradation in Manufactured Gas Plant Soils....Pages 239-243
Biomass Refining....Pages 245-252
Front Matter....Pages 237-237
Anaerobic Methane Fermentation in a Plug-Flow Reactor Treating Organic Wastes....Pages 253-263
Activated Sludge....Pages 265-270
Biotechnology and the Environment....Pages 271-278
Front Matter....Pages 279-279
An Efficient Computer Programme for the Simulation of Food Freezing Operations....Pages 281-289
Modelling and Simulation of Convective Green-Pea Drying....Pages 291-297
Front Matter....Pages 299-299
Modelling of the Baculovirus Infection Process in Insect-Cell Reactor Configurations....Pages 301-316
Use of Fed-Batch Operation to Improve Secondary Metabolite Production....Pages 317-323
Bioreactor Design for Animal Cell Cultures: With Special Reference to Mass Transfer....Pages 325-347
General Methodology in Bioprocess Engineering....Pages 349-364
Industrial Scale Antibiotic Production: Process Kinetic Analysis and Process Design....Pages 365-376
Oxygen Transfer and Microbial Growth....Pages 377-394
Classroom Adaptation of Escherichia Coli Single Cell Model....Pages 395-400
Kinetics of Continuous Microbial Culture: Plug-Flow, Chemostat, Turbidostat and Fed-Batch Principles....Pages 401-417
A Spreadsheet Simulation of a Differential Reactor for Estimating Kinetic Constants....Pages 419-433
Production of Fuel Alcohols by Fermentation: Engineering and Physiological Basis for Improving Processes....Pages 435-470
Back Matter....Pages 471-477
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