Ebook: The Geometry of Population Genetics
Author: Ethan Akin (auth.)
- Tags: Differential Geometry, Mathematical and Computational Biology
- Series: Lecture Notes in Biomathematics 31
- Year: 1979
- Publisher: Springer-Verlag Berlin Heidelberg
- Edition: 1
- Language: English
- pdf
The differential equations which model the action of selection and recombination are nonlinear equations which are impossible to It is even difficult to describe in general the solve explicitly. Recently, Shahshahani began using qualitative behavior of solutions. differential geometry to study these equations [28]. with this mono graph I hope to show that his ideas illuminate many aspects of pop ulation genetics. Among these are his proof and clarification of Fisher's Fundamental Theorem of Natural Selection and Kimura's Maximum Principle and also the effect of recombination on entropy. We also discover the relationship between two classic measures of 2 genetic distance: the x measure and the arc-cosine measure. There are two large applications. The first is a precise definition of the biological concept of degree of epistasis which applies to general (i.e. frequency dependent) forms of selection. The second is the unexpected appearance of cycling. We show that cycles can occur in the two-locus-two-allele model of selection plus recombination even when the fitness numbers are constant (i.e. no frequency dependence). This work is addressed to two different kinds of readers which accounts for its mode of organization. For the biologist, Chapter I contains a description of the entire work with brief indications of a proof for the harder results. I imagine a reader with some familiarity with linear algebra and systems of differential equations. Ideal background is Hirsch and Smale's text [15].
Content:
Front Matter....Pages I-IV
Introduction....Pages 1-2
The Vectorfield Model of Population Genetics....Pages 3-79
The Geometry of Epistasis....Pages 80-118
Selection, Recombination and Mutation....Pages 119-172
The Hopf Bifurcation....Pages 173-190
Back Matter....Pages 191-208
Content:
Front Matter....Pages I-IV
Introduction....Pages 1-2
The Vectorfield Model of Population Genetics....Pages 3-79
The Geometry of Epistasis....Pages 80-118
Selection, Recombination and Mutation....Pages 119-172
The Hopf Bifurcation....Pages 173-190
Back Matter....Pages 191-208
....