Ebook: Prostate Cancer: Biochemistry, Molecular Biology and Genetics

Prostate Cancer provides an up-to-date review of the biochemistry, molecular biology, and genetic changes in prostate cells that are the driving forces in the initiation and progression of cancer. It includes an overview by experts in the field of cell-cell interactions, including stem cells, reactive Stromal cells and membrane lipid rafts that are instrumental in the initiation and progression of prostate cancer.

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Prostate cancer is the most frequently diagnosed non-cutaneous malignancy in men, and the second leading cause of male cancer-related mortality in the United States. The last decade has seen unprecedented progress in the detection, prognosis, treatment and prevention of prostate cancer. These advances have been driven largely by an increased understanding of the underlying biochemistry, molecular biology and genetics of the disease. New cell and animal models have been developed that recapitulate the natural progression of prostate cancer. New technologies have allowed scientists to view in detail the genomic, proteomic, metabolomics and other –omic universe of cancer cells and tissues. This has resulted in a greater understanding of the pathophysiology of the disease.

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Prostate cancer is the most frequently diagnosed non-cutaneous malignancy in men, and the second leading cause of male cancer-related mortality in the United States. The last decade has seen unprecedented progress in the detection, prognosis, treatment and prevention of prostate cancer. These advances have been driven largely by an increased understanding of the underlying biochemistry, molecular biology and genetics of the disease. New cell and animal models have been developed that recapitulate the natural progression of prostate cancer. New technologies have allowed scientists to view in detail the genomic, proteomic, metabolomics and other –omic universe of cancer cells and tissues. This has resulted in a greater understanding of the pathophysiology of the disease.
Content:
Front Matter....Pages i-xii
Front Matter....Pages 1-1
Stem Cells in the Normal and Malignant Prostate....Pages 3-41
Role of Reactive Stroma in Prostate Cancer....Pages 43-63
The Role of Cholesterol in Prostate Cancer....Pages 65-83
Front Matter....Pages 85-85
PTEN in Prostate Cancer....Pages 87-137
ETS Fusion Genes in Prostate Cancer....Pages 139-183
Front Matter....Pages 185-185
Signaling Mechanisms of Vav3, a Guanine Nucleotide Exchange Factor and Androgen Receptor Coactivator, in Physiology and Prostate Cancer Progression....Pages 187-205
Transforming Growth Factor-Beta in Prostate Cancer....Pages 207-242
The p38 MAPK Pathway in Prostate Cancer....Pages 243-255
NF-kappaB2/p52 in Prostate Cancer....Pages 257-273
The Functional Role of DAB2IP, a Homeostatic Factor, in Prostate Cancer....Pages 275-293
Tyrosine Kinases in Prostate Cancer....Pages 295-322
Human Prostatic Acid Phosphatase in Prostate Carcinogenesis....Pages 323-348
Front Matter....Pages 349-349
Truncated Androgen Receptor Splice Variants in Prostate Cancer....Pages 351-382
Biology and Clinical Relevance of Estrogen Receptors in Prostate Cancer....Pages 383-419
Vitamin D and Prostate Cancer....Pages 421-442
HDAC6 Regulation of Androgen Signaling in Prostate Cancer....Pages 443-459
Beyond the Cell Cycle: Implications of D-type Cyclin Deregulation in Prostate Cancer....Pages 461-477
Front Matter....Pages 479-479
Role of Par-4 in Prostate Cancer....Pages 481-495
Autophagy and Prostate Cancer Therapeutics....Pages 497-518
Back Matter....Pages 519-522

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Prostate cancer is the most frequently diagnosed non-cutaneous malignancy in men, and the second leading cause of male cancer-related mortality in the United States. The last decade has seen unprecedented progress in the detection, prognosis, treatment and prevention of prostate cancer. These advances have been driven largely by an increased understanding of the underlying biochemistry, molecular biology and genetics of the disease. New cell and animal models have been developed that recapitulate the natural progression of prostate cancer. New technologies have allowed scientists to view in detail the genomic, proteomic, metabolomics and other –omic universe of cancer cells and tissues. This has resulted in a greater understanding of the pathophysiology of the disease.
Content:
Front Matter....Pages i-xii
Front Matter....Pages 1-1
Stem Cells in the Normal and Malignant Prostate....Pages 3-41
Role of Reactive Stroma in Prostate Cancer....Pages 43-63
The Role of Cholesterol in Prostate Cancer....Pages 65-83
Front Matter....Pages 85-85
PTEN in Prostate Cancer....Pages 87-137
ETS Fusion Genes in Prostate Cancer....Pages 139-183
Front Matter....Pages 185-185
Signaling Mechanisms of Vav3, a Guanine Nucleotide Exchange Factor and Androgen Receptor Coactivator, in Physiology and Prostate Cancer Progression....Pages 187-205
Transforming Growth Factor-Beta in Prostate Cancer....Pages 207-242
The p38 MAPK Pathway in Prostate Cancer....Pages 243-255
NF-kappaB2/p52 in Prostate Cancer....Pages 257-273
The Functional Role of DAB2IP, a Homeostatic Factor, in Prostate Cancer....Pages 275-293
Tyrosine Kinases in Prostate Cancer....Pages 295-322
Human Prostatic Acid Phosphatase in Prostate Carcinogenesis....Pages 323-348
Front Matter....Pages 349-349
Truncated Androgen Receptor Splice Variants in Prostate Cancer....Pages 351-382
Biology and Clinical Relevance of Estrogen Receptors in Prostate Cancer....Pages 383-419
Vitamin D and Prostate Cancer....Pages 421-442
HDAC6 Regulation of Androgen Signaling in Prostate Cancer....Pages 443-459
Beyond the Cell Cycle: Implications of D-type Cyclin Deregulation in Prostate Cancer....Pages 461-477
Front Matter....Pages 479-479
Role of Par-4 in Prostate Cancer....Pages 481-495
Autophagy and Prostate Cancer Therapeutics....Pages 497-518
Back Matter....Pages 519-522
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