Ebook: Mechanisms of Lymphocyte Activation and Immune Regulation VI: Cell Cycle and Programmed Cell Death in the Immune System

Since programmed cell death was first described in insects in 1964 and apoptosis was described in 1972, rapid progress has been made in understanding the basic mechanisms and genes regulating programmed cell death and apoptosis. In addition, defects in various genes regulating programmed cell death have been delineated in several experimental models of human diseases. This volume surveys various aspects of these rapidly developing areas of research in programmed cell death/apoptosis. This volume should be of interest to basic immunologists and molecular biologists. The volume begins with a historical perspective of cell death. The remainder of the volume is divided into four different parts. Part I deals with the signaling pathways in apoptosis, including cell cycle control of apoptosis, role of ceramide in apoptosis, role of antibody signaling, and biochemical regulation of apoptosis. The mechanisms for recognition of apoptotic lymphocytes by macrophages are also reviewed. Part II examines the role of various genes that regulate apoptosis, including the role ofFas, FasL, and other TNF family members in apoptosis and homeostatic regulation of immune response. Recently described splice variants and their influence on apoptosis are also reviewed, and the role of the members of the Bcl-2 family in apoptosis is discussed in detail. Part III reviews various aspects of apoptosis in B lymphocytes, including mechanisms that regulate apoptosis/survival of B lymphocytes and the regulation of Fas-mediated apoptosis in B lymphocytes.

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Content:
Front Matter....Pages i-ix
Apoptosis/Programmed Cell Death....Pages 1-9
Apoptosis and Its Regulation....Pages 11-20
Mechanisms for Recognition and Phagocytosis of Apoptotic Lymphocytes by Macrophages....Pages 21-28
Cytotoxic Lymphocyte Killing Enters the Ice Age....Pages 29-37
Cross-Talk between Ceramide and PKC Activity in the Control of Apoptosis in WEHI-231....Pages 39-55
Cell Cycle Control of T Cell Apoptosis Induced by Activation Through the T Cell Antigen Receptor....Pages 57-67
Role of Antibody Signaling in Inducing Tumor Dormancy....Pages 69-74
The Epstein—Barr Virus Gene BHRF1, a Homologue of the Cellular Oncogene Bcl-2, Inhibits Apoptosis Induced by Gamma Radiation and Chemotherapeutic Drugs....Pages 75-82
Structure—Function Analysis of Bcl-2 Family Proteins....Pages 83-97
Role of Ice-Proteases in Apoptosis....Pages 99-112
Fas-Mediated Apoptosis....Pages 113-117
Fas Splicing Variants and their Effect on Apoptosis....Pages 119-124
The Role of FasL and TNF in the Homeostatic Regulation of Immune Responses....Pages 125-134
Signals for Survival and Apoptosis in Normal and Neoplastic B Lymphocytes....Pages 135-138
Regulation of B Cell Apoptosis....Pages 139-144
Apoptotic Cell Death in the Chicken Bursa of Fabricius....Pages 145-154
Generation and Regulation of B Cell Autoreactivity Arising in the Periphery....Pages 155-165
Inducible Resistance to Fas-Mediated Apoptosis in Primary B Lymphocytes....Pages 167-176
The Thymus and T Cell Death....Pages 177-189
Genetic Regulation of Apoptosis in the Mouse Thymus....Pages 191-198
Regulation of T Cell Activation by CD28 and CTLA4....Pages 199-207
Granzyme B-Induced Apoptosis....Pages 209-217
Mature T Lymphocyte Apoptosis in the Healthy and Diseased Immune System....Pages 219-228
Autoimmunity Due to Defective NUR77, Fas, and TNF-RI Apoptosis....Pages 229-239
Back Matter....Pages 241-262
....Pages 263-270