Ebook: Recent Advances in Cellular and Molecular Aspects of Angiotensin Receptors

Scientific advances over the past two decades have afforded unprecedented oppor­ tunities to understand the structure and function of receptors, receptor-ligand interactions, and receptor signaling. The extent ofprogress in this area is underscored by the recent Nobel Prize for Medicine and Physiology to Alfred Gilman and Martin Rodbell, both of whose work in understanding receptorlG-protein interactions has redefined the way in which we think of how hormones and neurochemicals exert their activity on cellular function. This book is replete with examples of current research approaches to help us better understand the cellular roles in which the renin-angiotensin system and the angiotensin receptors participate. Clearly, defining the structure of angiotensin receptor subtypes is an important first step in cJarifying the mechanisms by which these receptors take part in cellular function. However, the chapters within this book range far beyond structural studies and encompass research on tissue specific expression of the angiotensin receptor subtypes, the genetic regulation ofthese receptors, and the unique function ofvarious angiotensin subtypes in different organ systems, such as the brain, the reproductive system, adipose tissue, the heart, and the kidneys.

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Content:
Front Matter....Pages i-xv
Characterization of a Cis-Regulatory Element and Trans-Acting Protein that Regulates Transcription of the Angiotensin II Type 1A Receptor Gene....Pages 1-10
Human AT1 Receptor Gene Regulation....Pages 11-21
Regulation of Gene Transcription of Angiotensin II Receptor Subtypes in the Heart....Pages 23-32
Sodium Induced Regulation of Angiotensin Receptor 1A And 1B in Rat Kidney....Pages 33-37
Characterization and Regulation of Angiotensin II Receptors in Rat Adipose Tissue....Pages 39-47
Changes in Angiotensin AT1 Receptor Density During Hypertension in Fructose-Fed Rats....Pages 49-58
Cardiac Effects of AII....Pages 59-69
AT1-Receptors and Cellular Actions of Angiotensin II in Neuronal Cultures of Stroke Prone-Spontaneously Hypertensive Rat Brain....Pages 71-78
Antisense Oligonucleotides for in Vivo Studies of Angiotensin Receptors....Pages 79-92
Interactions of Angiotensin II with Central Dopamine....Pages 93-103
Regulation of the Hypothalmic-Pituitary-Adrenal Axis and Vasopressin Secretion....Pages 105-112
Relationship Between the Drinking Response to Angiotensin II and Induction of Fos in the Brain....Pages 113-119
Identification of AT1 Receptors on Cultured Astrocytes....Pages 121-129
Structure-Activity Relationship of the Agonist-Antagonist Transition on the Type 1 Angiotensin II Receptor; the Search for Inverse Agonists....Pages 131-143
Molecular Cloning and Expression of Angiotensin II Type 2 Receptor Gene....Pages 145-152
Molecular Cloning of the Human AT2 Receptor....Pages 153-165
Molecular and Functional Characterization of Angiotensin II AT2 Receptor in Neuroblastoma N1E-115 Cells....Pages 167-173
Characterization of The AT2 Receptor on Rat Ovarian Granulosa Cells....Pages 175-182
AT2 Receptor Expression in Ovaries: A Review....Pages 183-187
Heterogeneity of Rat Angiotensin II AT2 Receptor....Pages 189-197
Heterogeneity of Angiotensin Type 2 (AT2) Receptors....Pages 199-208
Angiotensin II Stimulates Protein Phosphatase 2A Activity in Cultured Neuronal Cells Via Type 2 Receptors in a Pertussis Toxin Sensitive Fashion....Pages 209-215
Functional Aspects of Angiotensin Type 2 Receptor....Pages 217-224
Angiotensin Receptor Heterogeneity in the Dorsal Medulla Oblongata as Defined by Angiotensin-(1–7)....Pages 225-235
Atypical (Non-AT1, Non-AT2) Angiotensin Receptors....Pages 237-245
Brain Angiotensin II and Related Receptors: New Developments....Pages 247-252
Receptors for (3–8) Angiotensin in Brain Cells....Pages 253-263
Back Matter....Pages 265-270

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Content:
Front Matter....Pages i-xv
Characterization of a Cis-Regulatory Element and Trans-Acting Protein that Regulates Transcription of the Angiotensin II Type 1A Receptor Gene....Pages 1-10
Human AT1 Receptor Gene Regulation....Pages 11-21
Regulation of Gene Transcription of Angiotensin II Receptor Subtypes in the Heart....Pages 23-32
Sodium Induced Regulation of Angiotensin Receptor 1A And 1B in Rat Kidney....Pages 33-37
Characterization and Regulation of Angiotensin II Receptors in Rat Adipose Tissue....Pages 39-47
Changes in Angiotensin AT1 Receptor Density During Hypertension in Fructose-Fed Rats....Pages 49-58
Cardiac Effects of AII....Pages 59-69
AT1-Receptors and Cellular Actions of Angiotensin II in Neuronal Cultures of Stroke Prone-Spontaneously Hypertensive Rat Brain....Pages 71-78
Antisense Oligonucleotides for in Vivo Studies of Angiotensin Receptors....Pages 79-92
Interactions of Angiotensin II with Central Dopamine....Pages 93-103
Regulation of the Hypothalmic-Pituitary-Adrenal Axis and Vasopressin Secretion....Pages 105-112
Relationship Between the Drinking Response to Angiotensin II and Induction of Fos in the Brain....Pages 113-119
Identification of AT1 Receptors on Cultured Astrocytes....Pages 121-129
Structure-Activity Relationship of the Agonist-Antagonist Transition on the Type 1 Angiotensin II Receptor; the Search for Inverse Agonists....Pages 131-143
Molecular Cloning and Expression of Angiotensin II Type 2 Receptor Gene....Pages 145-152
Molecular Cloning of the Human AT2 Receptor....Pages 153-165
Molecular and Functional Characterization of Angiotensin II AT2 Receptor in Neuroblastoma N1E-115 Cells....Pages 167-173
Characterization of The AT2 Receptor on Rat Ovarian Granulosa Cells....Pages 175-182
AT2 Receptor Expression in Ovaries: A Review....Pages 183-187
Heterogeneity of Rat Angiotensin II AT2 Receptor....Pages 189-197
Heterogeneity of Angiotensin Type 2 (AT2) Receptors....Pages 199-208
Angiotensin II Stimulates Protein Phosphatase 2A Activity in Cultured Neuronal Cells Via Type 2 Receptors in a Pertussis Toxin Sensitive Fashion....Pages 209-215
Functional Aspects of Angiotensin Type 2 Receptor....Pages 217-224
Angiotensin Receptor Heterogeneity in the Dorsal Medulla Oblongata as Defined by Angiotensin-(1–7)....Pages 225-235
Atypical (Non-AT1, Non-AT2) Angiotensin Receptors....Pages 237-245
Brain Angiotensin II and Related Receptors: New Developments....Pages 247-252
Receptors for (3–8) Angiotensin in Brain Cells....Pages 253-263
Back Matter....Pages 265-270
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