Ebook: Intercellular Signalling in the Mammary Gland

All being done, we went to Mrs Shipmans, who is a great butter-woman; and I did see there the most of milke and cream, and the cleanest, that I ever saw in my life (29 May 1661). Among others, Sir Wm. Petty did tell me that in good earnest, he hath in his will left such parts of his estate to him that could invent such and such things -as among others, that could discover truly the way of milk coming into the breasts of a woman ... (22 March 1665). My wife tells me that she hears that my poor aunt James hath had her breast cut off here in tow- her breast having long been out of order (5 May 1665). From the Diary of Samuel Pepys, published as The Shorter Pepys (edited by R. Latham), Penguin Books (1987) The long-standing ultimate importance of research on the mammary gland is illustrated by the importance attached to cows' milk for human consumption, to human lactation and to breast cancer by Samuel Pepys and his contemporaries in the middle of the 17th century. Research has tended to develop in isolation in these three areas of continuing contemporary importance largely because in most countries, the underlying science of agricultural productivity is funded separately from the underlying science of human health and welfare.

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Mammary Development: Growth and Growth Factors: The Environment of the Mammary Secretory Cell (C.H. Knight). Role of Bovine Placental Lactogen in Intercellular Signalling during Mammary Growth and Lactation (R.J. Collier et al.). Expression of Hox Genes in Normal and Neoplastic Mouse Mammary Gland (Y. Friedmann, C.W. Daniel). Apoptosis in Mammary Gland Involution: Isolation and Characterization of Apoptosisspecific Genes (W. Bielke et al.). Mammary Development: Differentiation and Gene Expression: Extracellular Matrix Dependent Gene Regulation in Mammary Epithelial Cells (C. Schmidhauser et al.). Regulation of Milk Secretion and Composition by Growth Hormone and Prolactin (D.J. Flint). Basement Membrane in the Control of Mammary Gland Function (C.H. Streuli). Heterogeneous Expression and Synthesis of Human Serum Albumin in the Mammary Gland of Transgenic Mice (I. Barash et al). Milk Secretion: Autocrine Control of Milk Secretion: Development of the Concept (M. Peaker). Endocrine and Autocrine Strategies for the Control of Lactation in Women and Sows (P.E. Hartmann et al.). Autocrine Control of Milk Secretion: From Concept to Application (C.J. Wilde et al.). A Role for Mediumchain Fatty Acids in the Regulation of Lipid Synthesis in Milk Stasis? (D.H. Williamson et al.). 41 additional articles. Appendix. Index.

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Mammary Development: Growth and Growth Factors: The Environment of the Mammary Secretory Cell (C.H. Knight). Role of Bovine Placental Lactogen in Intercellular Signalling during Mammary Growth and Lactation (R.J. Collier et al.). Expression of Hox Genes in Normal and Neoplastic Mouse Mammary Gland (Y. Friedmann, C.W. Daniel). Apoptosis in Mammary Gland Involution: Isolation and Characterization of Apoptosisspecific Genes (W. Bielke et al.). Mammary Development: Differentiation and Gene Expression: Extracellular Matrix Dependent Gene Regulation in Mammary Epithelial Cells (C. Schmidhauser et al.). Regulation of Milk Secretion and Composition by Growth Hormone and Prolactin (D.J. Flint). Basement Membrane in the Control of Mammary Gland Function (C.H. Streuli). Heterogeneous Expression and Synthesis of Human Serum Albumin in the Mammary Gland of Transgenic Mice (I. Barash et al). Milk Secretion: Autocrine Control of Milk Secretion: Development of the Concept (M. Peaker). Endocrine and Autocrine Strategies for the Control of Lactation in Women and Sows (P.E. Hartmann et al.). Autocrine Control of Milk Secretion: From Concept to Application (C.J. Wilde et al.). A Role for Mediumchain Fatty Acids in the Regulation of Lipid Synthesis in Milk Stasis? (D.H. Williamson et al.). 41 additional articles. Appendix. Index.
Content:
Front Matter....Pages i-xi
The Environment of the Mammary Secretory Cell....Pages 1-11
Role of Bovine Placental Lactogen in Intercellular Signalling during Mammary Growth and Lactation....Pages 13-24
Expression of Hox Genes in Normal and Neoplastic Mouse Mammary Gland....Pages 25-33
Local Signals for Growth Cessation and Differentiation in the Mammary Gland....Pages 35-44
Apoptosis in Mammary Gland Involution: Isolation and Characterization of Apoptosis-Specific Genes....Pages 45-55
The Role of erbB-Family Genes and Wnt Genes in Normal and Preneoplastic Mammary Epithelium, Studied by Tissue Reconstitution....Pages 57-66
Interplay between Epidermal Growth Factor Receptor and Estrogen Receptor in Progression to Hormone Independence of Human Breast Cancer....Pages 67-68
Effect of Plane of Nutrition on Mammary Gland Development in Prepubertal Goats....Pages 69-70
Activation of Basic Fibroblast Growth Factor (bFGF) by Heparan Sulphate (HS)....Pages 71-72
High Density Culture of Immuno-Magnetically Separated Human Mammary Luminal Cells....Pages 73-74
Molecular Analysis of the Effects of Oestradiol in an in vivo Model of Normal Human Breast Proliferation....Pages 75-76
Juxtacrine Growth Stimulation of Mouse Mammary Cells in Culture....Pages 77-78
Fibroblast Growth Factors in Mammary Development and Cancer....Pages 79-80
Evidence of Growth Factor Production by Sheep Myoepithelial and Alveolar Epithelial Cells: Potential for Autocrine/Paracrine Interactions....Pages 81-82
Derivation of Conditionally Immortal Mammary Cell Lines....Pages 83-84
Effect of Relaxin on Primary Cultures of Goat Mammary Epithelial Cells....Pages 85-85
Differential Effects of Growth Factors Acting by Autocrine and Paracrine Pathways in Breast Cancer Cells....Pages 87-88
Validation of Transforming Growth Factor ?-1 Binding Assay for Bovine Mammary Tissue....Pages 89-90
Endocrine Effect of IGF-I on Mammary Growth in Prepubertal Heifers....Pages 91-92
Local Control of Mammary Apoptosis by Milk Stasis....Pages 93-94
Immunolocalisation of Insulin-Like Growth Factors and Basic Fibroblast Growth Factor in the Bovine Mammary Gland....Pages 95-96
Flow Sorting and Clonal Analysis of Mouse Mammary Epithelium....Pages 97-98
Cytokine Expression in Normal and Neoplastic Breast Tissue....Pages 99-100
Production of an Insulin-Like Growth Factor Binding Protein by the Involuting Rat Mammary Gland....Pages 101-102
Developmental and Hormonal Regulation of Wnt Gene Expression in the Mouse Mammary Gland....Pages 103-104
Extracellular Matrix Dependent Gene Regulation in Mammary Epithelial Cells....Pages 105-106
Regulation of Milk Secretion and Composition by Growth Hormone and Prolactin....Pages 107-119
Basement Membrane in the Control of Mammary Gland Function....Pages 121-129
Asynchronous Concurrent Secretion of Milk Proteins in the Tammar Wallaby (Macropus Eugenii)....Pages 131-140
Heterogeneous Expression and Synthesis of Human Serum Albumin in the Mammary Gland of Transgenic Mice....Pages 141-151
Post-Transcriptional Regulation of Casein Gene Expression by Prolactin and Growth Hormone in Lactating Rat Mammary Gland....Pages 153-170
Characterization of Transcriptional Control Elements in the Mammary Gland and Pancreas: Studies of the Carboxyl Ester Lipase Gene....Pages 171-172
Oligosaccharide Analysis of Epithelial Mammary Tissues....Pages 173-174
Human Bile Salt-Activated Lipase: Structural Organisation at the C-Terminus....Pages 175-176
Dramatic Changes in Gap Junction Expression in the Mammary Gland During Pregnancy, Lactation and Involution....Pages 177-178
Aromatase Induction in Stromal Vascular Cells from Human Breast Adipose Tissue by Growth Factors....Pages 179-180
Developmental Regulation of Homeobox Genes in the Mouse Mammary Gland....Pages 181-182
Murine ?-Lactalbumin Gene Inactivation and Replacment....Pages 183-184
Differential Expression of ?-Lactoglobulin Alleles A and B in Dairy Cattle....Pages 185-186
DNA Replication, ?-Casein Gene Transcription and DNase-I Sensitivity of ?-Casein Gene in Rabbit Mammary Cell Nuclei....Pages 187-188
Autocrine Control of Milk Secretion: Development of the Concept....Pages 189-190
Endocrine and Autocrine Strategies for the Control of Lactation in Women and Sows....Pages 191-192
Autocrine Control of Milk Secretion: From Concept to Application....Pages 193-202
A Role for Medium-Chain Fatty Acids in the Regulation of Lipid Synthesis in Milk Stasis?....Pages 203-225
The Secretory Pathway for Milk Protein Secretion and Its Regulation....Pages 227-237
Dose-Dependent Effects of Oxytocin on the Microcirculation in the Mammary Gland of the Lactating Rat....Pages 239-251
Effects of Triiodothyronine Administration on the Disposal of Oral [1-14C]-Triolein, Lipoprotein Lipase Activity and Lipogenesis in the Rat during Lactation and on Removal of the Litter....Pages 253-263
Induction of Immune Responses in the Bovine Mammary Gland....Pages 265-266
Cultured Mammary Epithelial Cells Secrete a Factor Which Suppresses Lipoprotein Lipase Production by 3T3-L1 Adipocytes....Pages 267-268
Localisation of Annexin V and Annexin VI in Lactating Mammary Epithelial Cells....Pages 269-270
Scientific Papers Published Since 1984 by Speakers at This Symposium in the Cab Abstracts Database....Pages 271-272
Back Matter....Pages 273-274
....Pages 275-276