Ebook: Biochemical, Pharmacological, and Clinical Aspects of Nitric Oxide

A decade ago, for most scientists investigating various issues in life sciences the word "NO" was used in a negative context. It is astounding to observe how recently researchers are addressing the issue of NO, namely, nitric oxide, in over fifty publications weekly. Science journal, while naming nitric oxide: "Molecule of the Year" (December 1992), said it all: "NO news is good news. " For a long period of time NO was considered as a pollutant and every ecology­ minded person tried to eliminate it. It was the discovery of NO involvement in the process of host killing by macrophages and several years later the finding that EDRF is none else but NO, that promoted this field. Nitric oxide's major role in the control of blood pressure is merely one factor of an extensive list of effects and functions attributed to it. NO is implicated in long-term potentiation (LPT), a principal process involved in memory consolidation and it is considered as the main biochemical substance responsible for penile erection. It should be noted that additional roles for NO are discovered continuously as many laboratories join the quest for the mystery of this small molecule. The observation that NO is involved in various biological processes is not unique, as other second messengers (i. e. , cyclic AMP), participate in a diverse set of functions.

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The Nitric Oxide Signal Transduction System (F. Murad). Chemistry and Biochemistry of Nitric Oxide: Mechanisms of Mammalian Nitric Oxide Biosynthesis (P.L. Feldman et al.). Nitric Oxide Synthase Inhibitors: Mechanisms of Action and in vivo Studies (O.W. Griffith). Biosynthesis of Nitric Oxide (B. Mayer). Pharmacology and Drug Development: Initial Clinical Experience with the Intracavernous Application of the Nitric Oxide Donor Sin1 in the Treatment of Patients with Erectile Dysfunction (M.C. Truss et al.). Nitric Oxideinduced Lymphocyte Activation: A Role for G Proteins (H.M. Lander et al.). Nitric Oxide and the Respiratory and Cardiovascular Systems: The Role of Nitric Oxide in Nonadrenergic Noncholinergic Neural Relaxation of Mammalian Airway Smooth Muscle (L. Diamond et al.). Nitric Oxide: A Putative Modulator of Muscarinic Receptor in the Airways Smooth Muscles (N. Allon, Y. Meshulam). Vasculoprotective Actions of Nitric Oxide (A.M. Lefer). Nitric Oxide and Brain Functions: Nitric Oxide and Cerebrovascular Regulation (T. Dalkara, M.A. Moskowitz). Multiparametric Responses to Cortical Spreading Depression under Nitric Oxide Synthesis Inhibition (S. Meilin et al.). 19 additional articles. Index.

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The Nitric Oxide Signal Transduction System (F. Murad). Chemistry and Biochemistry of Nitric Oxide: Mechanisms of Mammalian Nitric Oxide Biosynthesis (P.L. Feldman et al.). Nitric Oxide Synthase Inhibitors: Mechanisms of Action and in vivo Studies (O.W. Griffith). Biosynthesis of Nitric Oxide (B. Mayer). Pharmacology and Drug Development: Initial Clinical Experience with the Intracavernous Application of the Nitric Oxide Donor Sin1 in the Treatment of Patients with Erectile Dysfunction (M.C. Truss et al.). Nitric Oxideinduced Lymphocyte Activation: A Role for G Proteins (H.M. Lander et al.). Nitric Oxide and the Respiratory and Cardiovascular Systems: The Role of Nitric Oxide in Nonadrenergic Noncholinergic Neural Relaxation of Mammalian Airway Smooth Muscle (L. Diamond et al.). Nitric Oxide: A Putative Modulator of Muscarinic Receptor in the Airways Smooth Muscles (N. Allon, Y. Meshulam). Vasculoprotective Actions of Nitric Oxide (A.M. Lefer). Nitric Oxide and Brain Functions: Nitric Oxide and Cerebrovascular Regulation (T. Dalkara, M.A. Moskowitz). Multiparametric Responses to Cortical Spreading Depression under Nitric Oxide Synthesis Inhibition (S. Meilin et al.). 19 additional articles. Index.
Content:
Front Matter....Pages i-xi
The Nitric Oxide Signal Transduction System....Pages 1-11
Mechanisms of Mammalian Nitric Oxide Biosynthesis....Pages 13-20
Nitric Oxide Synthase Inhibitors: Mechanism of Action and in Vivo Studies....Pages 21-36
Biosynthesis of Nitric Oxide....Pages 37-48
Mechanisms of Shear Stress-Dependent Endothelial Nitric Oxide Release: Cardiovascular Implications....Pages 49-56
Determination of Nitric Oxide Levels by Fluorescence Spectroscopy....Pages 57-66
S-Nitrosothiols: Correlation of Biological Chemistry with Physiological Actions....Pages 67-78
Initial Clinical Experience with the Intracavernous Application of the Nitric Oxide Donor Sin 1 in the Treatment of Patients with Erectile Dysfunction....Pages 79-83
Nitric Oxide-Induced Lymphocyte Activation: A Role for G Proteins....Pages 85-91
Coronary Haemodynamic Profile of the New Nitro-Ester Derivative ITF 296 in the Conscious Dog....Pages 93-101
Nitric Oxide in Amphibian Photoreceptors....Pages 103-110
The Involvement of L-Arginine-Nitric Oxide Pathway in the Anti-Rickettsial Activity of Macrophagelike Cells....Pages 111-115
Modulation of LDL and oxy-LDL Catabolism by No-Donors and PGE2 in Human Peripheral Blood Lymphocytes and Rat Macrophages....Pages 117-122
The Role of Nitric Oxide in Nonadrenergic Noncholingergic Neural Relaxation of Mammalian Airway Smooth Muscle....Pages 123-130
Nitric Oxide: A Putative Modulator of Muscarinic Receptor in the Airways Smooth Muscles....Pages 131-136
Comparative Effects of N?-Nitro-L-Arginine, N?-Nitro-L-Arginine Methyl Ester, and N?-Nitro-L-Arginine Benzyl Ester on Vasodilator Responses to Acetylcholine and Substance P....Pages 137-144
Vascular Responses to Endothelin-1 in Conscious Rats: Modulation by Endogenous Nitric Oxide....Pages 145-152
Stimulation of Endogenous No-Production Influences the Dilation of the Capillary Microvasculature in Vivo....Pages 153-160
Induction of Nadph — Diaphorase — Activity with Endotoxin in Rat Heart and Spleen in Vivo....Pages 161-165
Vasculoprotective Actions of Nitric Oxide....Pages 167-173
Nitric Oxide: An Endogenous Inhibitor of Balloon Catheter-Induced Intimal Hyperplasia....Pages 175-180
Generation and Roles of Nitric Oxide in Anaphylaxis....Pages 181-188
Nitric Oxide and Cerebrovascular Regulation....Pages 189-194
Multiparametric Responses to Cortical Spreading Depression Under Nitric Oxide Synthesis Inhibition....Pages 195-204
The Effects of Sodium Nitroprusside and L-Glutamate on the Regulation of the Cytoskeletal Associated Protein Tau in Primary Cultured Neurons from Rat....Pages 205-212
Brain Lesion and Nitric Oxide Synthase/Nadph-Diaphorase: a Light and Electron Microscopical Study....Pages 213-220
Dose-Dependent Effects of Nitric Oxide on in Vivo and in Vitro Neuronal Functions....Pages 221-230
Inhibition of Nitric Oxide Production Impairs Specific Cognitive Processes in Rats....Pages 231-238
The Effect of Aging on Nos Activity in the Rat Hippocampus and Its Relation to Cognitive Functions....Pages 239-244
Back Matter....Pages 245-248

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The Nitric Oxide Signal Transduction System (F. Murad). Chemistry and Biochemistry of Nitric Oxide: Mechanisms of Mammalian Nitric Oxide Biosynthesis (P.L. Feldman et al.). Nitric Oxide Synthase Inhibitors: Mechanisms of Action and in vivo Studies (O.W. Griffith). Biosynthesis of Nitric Oxide (B. Mayer). Pharmacology and Drug Development: Initial Clinical Experience with the Intracavernous Application of the Nitric Oxide Donor Sin1 in the Treatment of Patients with Erectile Dysfunction (M.C. Truss et al.). Nitric Oxideinduced Lymphocyte Activation: A Role for G Proteins (H.M. Lander et al.). Nitric Oxide and the Respiratory and Cardiovascular Systems: The Role of Nitric Oxide in Nonadrenergic Noncholinergic Neural Relaxation of Mammalian Airway Smooth Muscle (L. Diamond et al.). Nitric Oxide: A Putative Modulator of Muscarinic Receptor in the Airways Smooth Muscles (N. Allon, Y. Meshulam). Vasculoprotective Actions of Nitric Oxide (A.M. Lefer). Nitric Oxide and Brain Functions: Nitric Oxide and Cerebrovascular Regulation (T. Dalkara, M.A. Moskowitz). Multiparametric Responses to Cortical Spreading Depression under Nitric Oxide Synthesis Inhibition (S. Meilin et al.). 19 additional articles. Index.
Content:
Front Matter....Pages i-xi
The Nitric Oxide Signal Transduction System....Pages 1-11
Mechanisms of Mammalian Nitric Oxide Biosynthesis....Pages 13-20
Nitric Oxide Synthase Inhibitors: Mechanism of Action and in Vivo Studies....Pages 21-36
Biosynthesis of Nitric Oxide....Pages 37-48
Mechanisms of Shear Stress-Dependent Endothelial Nitric Oxide Release: Cardiovascular Implications....Pages 49-56
Determination of Nitric Oxide Levels by Fluorescence Spectroscopy....Pages 57-66
S-Nitrosothiols: Correlation of Biological Chemistry with Physiological Actions....Pages 67-78
Initial Clinical Experience with the Intracavernous Application of the Nitric Oxide Donor Sin 1 in the Treatment of Patients with Erectile Dysfunction....Pages 79-83
Nitric Oxide-Induced Lymphocyte Activation: A Role for G Proteins....Pages 85-91
Coronary Haemodynamic Profile of the New Nitro-Ester Derivative ITF 296 in the Conscious Dog....Pages 93-101
Nitric Oxide in Amphibian Photoreceptors....Pages 103-110
The Involvement of L-Arginine-Nitric Oxide Pathway in the Anti-Rickettsial Activity of Macrophagelike Cells....Pages 111-115
Modulation of LDL and oxy-LDL Catabolism by No-Donors and PGE2 in Human Peripheral Blood Lymphocytes and Rat Macrophages....Pages 117-122
The Role of Nitric Oxide in Nonadrenergic Noncholingergic Neural Relaxation of Mammalian Airway Smooth Muscle....Pages 123-130
Nitric Oxide: A Putative Modulator of Muscarinic Receptor in the Airways Smooth Muscles....Pages 131-136
Comparative Effects of N?-Nitro-L-Arginine, N?-Nitro-L-Arginine Methyl Ester, and N?-Nitro-L-Arginine Benzyl Ester on Vasodilator Responses to Acetylcholine and Substance P....Pages 137-144
Vascular Responses to Endothelin-1 in Conscious Rats: Modulation by Endogenous Nitric Oxide....Pages 145-152
Stimulation of Endogenous No-Production Influences the Dilation of the Capillary Microvasculature in Vivo....Pages 153-160
Induction of Nadph — Diaphorase — Activity with Endotoxin in Rat Heart and Spleen in Vivo....Pages 161-165
Vasculoprotective Actions of Nitric Oxide....Pages 167-173
Nitric Oxide: An Endogenous Inhibitor of Balloon Catheter-Induced Intimal Hyperplasia....Pages 175-180
Generation and Roles of Nitric Oxide in Anaphylaxis....Pages 181-188
Nitric Oxide and Cerebrovascular Regulation....Pages 189-194
Multiparametric Responses to Cortical Spreading Depression Under Nitric Oxide Synthesis Inhibition....Pages 195-204
The Effects of Sodium Nitroprusside and L-Glutamate on the Regulation of the Cytoskeletal Associated Protein Tau in Primary Cultured Neurons from Rat....Pages 205-212
Brain Lesion and Nitric Oxide Synthase/Nadph-Diaphorase: a Light and Electron Microscopical Study....Pages 213-220
Dose-Dependent Effects of Nitric Oxide on in Vivo and in Vitro Neuronal Functions....Pages 221-230
Inhibition of Nitric Oxide Production Impairs Specific Cognitive Processes in Rats....Pages 231-238
The Effect of Aging on Nos Activity in the Rat Hippocampus and Its Relation to Cognitive Functions....Pages 239-244
Back Matter....Pages 245-248
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