Ebook: Neural Development and Schizophrenia: Theory and Research

This is the third meeting we have organized which has explored the meaning of fetal neural developmental disruption in the etiology of schiwphrenia. The first was sponsored by the Schiwphrenia Research Branch with the scientific cooperation of Dr. David Shore. We met in Washington; the output of the meeting was published in a book entitled, Fetal Neural Development and Adult Schizophrenia. Cambridge University Press. 1991. The next meeting was an Advanced Research Workshop sponsored by NATO and was held at n Ciocco. Castelvecchio Pascoli. This meeting was reported in a NATO volume. Developmental Neuropathology of Schizophrenia and was edited by Mednick. Cannon. Barr and La Fosse. The current meeting has noted several advances in the field. There are additional psychiatric illnesses which have been found to be related to maternal viral infection in the second trimester. There have been studies reported which have definitely observed a viral infection in the mothers of fetuses who later evidenced schirophrenia. More evidence has been published which has replicated the "second-trimester effect." In the future studies will be wise to provide serological evidence of a viral infection and information on the precise viruses involved. Another important step will be to determine whether second-trimester maternal viral infection is related to a behavioral deficit in the infant. If neural development has been compromised. it might be possible to detect deficits in the infant with the proper measures. We look forward to future meetings at which these new areas might be explored.

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Introduction: A Multidisciplinary Approach to Understanding the Neurodevelopment of Schizophrenia; J.M. Hollister, et al.TheDeveloping Brain: Fetal Development and Schizophrenia: Historical Observations from Teratology; W.O. McClure.Pathology of the Brain ofSchizophrenics: Implications for Neurodevelopment: NeuroimagingStudies: Structural Brain Abnormalities in Schizophrenia: Distribution, Etiology, and Implications; L.T. Eyler-Zorilla, T.D.Cannon.Animal Models: Fetal Developmental Animal Model of Schizophrenia with Dopamine, Acetylcholine, and Nitric Oxide Perspective; M. Lyon, W.O. McClure.Premorbid Signs and ClinicalCharacteristics of Schizophrenia: Childhood Risk Factors for Adult Schizophrenia in a General Population Cohort at Age 43 Years; P.Jones, et al.Fetal Neurodevelopmental Disterbance: Sources andConsequences: Fetal Viral Infections: Fetal Viral Infection and Adult Schizophrenia: Empirical Findings and Interpretations; R.A.Mach?n, et al.Antibody Exposure: Disruption of Fetal Brain Development by Maternal Antibodies as an Etiological Factor in Schizophrenia; P. Laing, et al. 5 additional articles. Index.

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Introduction: A Multidisciplinary Approach to Understanding the Neurodevelopment of Schizophrenia; J.M. Hollister, et al.TheDeveloping Brain: Fetal Development and Schizophrenia: Historical Observations from Teratology; W.O. McClure.Pathology of the Brain ofSchizophrenics: Implications for Neurodevelopment: NeuroimagingStudies: Structural Brain Abnormalities in Schizophrenia: Distribution, Etiology, and Implications; L.T. Eyler-Zorilla, T.D.Cannon.Animal Models: Fetal Developmental Animal Model of Schizophrenia with Dopamine, Acetylcholine, and Nitric Oxide Perspective; M. Lyon, W.O. McClure.Premorbid Signs and ClinicalCharacteristics of Schizophrenia: Childhood Risk Factors for Adult Schizophrenia in a General Population Cohort at Age 43 Years; P.Jones, et al.Fetal Neurodevelopmental Disterbance: Sources andConsequences: Fetal Viral Infections: Fetal Viral Infection and Adult Schizophrenia: Empirical Findings and Interpretations; R.A.Mach?n, et al.Antibody Exposure: Disruption of Fetal Brain Development by Maternal Antibodies as an Etiological Factor in Schizophrenia; P. Laing, et al. 5 additional articles. Index.
Content:
Front Matter....Pages i-x
A Multidisciplinary Approach to the Neurodevelopment of Schizophrenia....Pages 1-11
Fetal Development and Schizophrenia: Historical Observations from Teratology....Pages 13-25
Potential Mechanisms of Defective Brain Development in Schizophrenia....Pages 27-56
Structural Brain Abnormalities in Schizophrenia: Distribution, Etiology, and Implications....Pages 57-69
Cerebral Asymmetries in Schizophrenia: Further Evidence for a Lateralization Hypothesis....Pages 71-77
Morphologic Markers of Neurodevelopmental Paths: Revisited....Pages 79-94
Fetal Developmental Animal Model of Schizophrenia with Dopamine, Acetylcholine, and Nitric Oxide Perspectives....Pages 95-115
Metal Exposure of the Squirrel Monkey Fetus as a Model of Human Neuropsychiatric Disorders....Pages 117-137
AMPA Receptor-Induced Dopaminergic Cell Death: A Model for the Pathogenesis of Hypofrontality and Negative Symptoms in Schizophrenia....Pages 139-150
Childhood Risk Factors for Adult Schizophrenia in a General Population Birth Cohort at Age 43 Years....Pages 151-176
Subtypes of Schizophrenia: Diagnostic and Conceptual Issues....Pages 177-189
Fetal Viral Infection and Adult Schizophrenia: Empirical Findings and Interpretation....Pages 191-202
How Can We Judge Whether Or Not Prenatal Exposure to Influenza Causes Schizophrenia?....Pages 203-214
Disruption of Fetal Brain Development by Maternal Antibodies as an Etiological Factor in Schizophrenia....Pages 215-246
Back Matter....Pages 247-262

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Introduction: A Multidisciplinary Approach to Understanding the Neurodevelopment of Schizophrenia; J.M. Hollister, et al.TheDeveloping Brain: Fetal Development and Schizophrenia: Historical Observations from Teratology; W.O. McClure.Pathology of the Brain ofSchizophrenics: Implications for Neurodevelopment: NeuroimagingStudies: Structural Brain Abnormalities in Schizophrenia: Distribution, Etiology, and Implications; L.T. Eyler-Zorilla, T.D.Cannon.Animal Models: Fetal Developmental Animal Model of Schizophrenia with Dopamine, Acetylcholine, and Nitric Oxide Perspective; M. Lyon, W.O. McClure.Premorbid Signs and ClinicalCharacteristics of Schizophrenia: Childhood Risk Factors for Adult Schizophrenia in a General Population Cohort at Age 43 Years; P.Jones, et al.Fetal Neurodevelopmental Disterbance: Sources andConsequences: Fetal Viral Infections: Fetal Viral Infection and Adult Schizophrenia: Empirical Findings and Interpretations; R.A.Mach?n, et al.Antibody Exposure: Disruption of Fetal Brain Development by Maternal Antibodies as an Etiological Factor in Schizophrenia; P. Laing, et al. 5 additional articles. Index.
Content:
Front Matter....Pages i-x
A Multidisciplinary Approach to the Neurodevelopment of Schizophrenia....Pages 1-11
Fetal Development and Schizophrenia: Historical Observations from Teratology....Pages 13-25
Potential Mechanisms of Defective Brain Development in Schizophrenia....Pages 27-56
Structural Brain Abnormalities in Schizophrenia: Distribution, Etiology, and Implications....Pages 57-69
Cerebral Asymmetries in Schizophrenia: Further Evidence for a Lateralization Hypothesis....Pages 71-77
Morphologic Markers of Neurodevelopmental Paths: Revisited....Pages 79-94
Fetal Developmental Animal Model of Schizophrenia with Dopamine, Acetylcholine, and Nitric Oxide Perspectives....Pages 95-115
Metal Exposure of the Squirrel Monkey Fetus as a Model of Human Neuropsychiatric Disorders....Pages 117-137
AMPA Receptor-Induced Dopaminergic Cell Death: A Model for the Pathogenesis of Hypofrontality and Negative Symptoms in Schizophrenia....Pages 139-150
Childhood Risk Factors for Adult Schizophrenia in a General Population Birth Cohort at Age 43 Years....Pages 151-176
Subtypes of Schizophrenia: Diagnostic and Conceptual Issues....Pages 177-189
Fetal Viral Infection and Adult Schizophrenia: Empirical Findings and Interpretation....Pages 191-202
How Can We Judge Whether Or Not Prenatal Exposure to Influenza Causes Schizophrenia?....Pages 203-214
Disruption of Fetal Brain Development by Maternal Antibodies as an Etiological Factor in Schizophrenia....Pages 215-246
Back Matter....Pages 247-262
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