Ebook: Oxygen Transport to Tissue XVI

Since its inception in 1973, The International Society on Oxygen Transport to Tissue (ISOTT) has provided a unique forum to facilitate and encourage scientific interaction and debate. Welcoming scientists and clinicians from a broad spectrum of disciplines, each with their own particular skills and expertise, ISOTT unites them under the common theme of oxygen transport. The successful blend of scientific presentations and informal discussion which characterizes ISOTT is epitomized best by the many fundamental discoveries and technical advancements which it has spawned. The breadth and strengths of The Society's scientific base promotes the rapid progression of ideas from theoretical concepts to rigorous scientific testing and often, ultimately to the clinical arena. Each publication of the ISOTT proceedings has been recognized by Science Citation Index listing and the papers frequently establish scientific precedents and become considered as standard works in their respective fields. The 21st ISOTT Meeting was held in San Diego from August 14th through August 18th, 1993. The San Diego Meeting attracted about 150 registrants and 40 accompanying persons. Ten state-of-the-art lectures were presented by international experts in ~ transport and there were in addition two symposia -one dealing with assessment of tissue hypoxia and the other with functional heterogeneity in different organ systems. There were 100 free communications, consisting of posters accompanied by an abbreviated oral summary. All manuscripts were reviewed by the Editors for form and content, but as is customary for the ISOTT proceedings, rigorous scientific peer review was not undertaken.

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Theoretical Models of O₂ Transport: Local Plasma Convection Can Be Important for Oxygen Release in Tissue Capillaries; C. Bos, et al. Abstracts. Methods and Instrumentation: Phosphorescence Quenching, Magnetic Resonance Techniques, Near Infrared Spectroscopy, Other Abstracts. Systemic Oxygen Transport: Is Red Cell Flow Heterogeneity a Critical Variable in the Regulation and Limitation of Oxygen Transport to Tissue? B.R. Duling Abstracts.Heart: Effects of Energy Demand in Ischemic and in Hypoxemic Isolated Rat Hearts; M. Samaja Abstracts. Lung: Respiratory Gas Exchange and Inert Gas Retention during Partial Liquid Ventilation; E.A. Mates Abstracts. Brain: Effect of Mild Hypothermia on Active and Basal Cerebral Oxygen Metabolism and Blood Flow; E.M. Nemoto, et al.Skeletal Muscle: Oxygen Supply to Exercising Muscle, Roles of Diffusion Limitation and Heterogeneity of Blood Flow; J. Piiper Abstracts. Kidney and Gut: Filtration, Reabsorption and Oxygen in the Kidney;R.C. Blantz Abstracts. Tumor: Abstracts. 110 additional articles. Index.

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Theoretical Models of O₂ Transport: Local Plasma Convection Can Be Important for Oxygen Release in Tissue Capillaries; C. Bos, et al. Abstracts. Methods and Instrumentation: Phosphorescence Quenching, Magnetic Resonance Techniques, Near Infrared Spectroscopy, Other Abstracts. Systemic Oxygen Transport: Is Red Cell Flow Heterogeneity a Critical Variable in the Regulation and Limitation of Oxygen Transport to Tissue? B.R. Duling Abstracts.Heart: Effects of Energy Demand in Ischemic and in Hypoxemic Isolated Rat Hearts; M. Samaja Abstracts. Lung: Respiratory Gas Exchange and Inert Gas Retention during Partial Liquid Ventilation; E.A. Mates Abstracts. Brain: Effect of Mild Hypothermia on Active and Basal Cerebral Oxygen Metabolism and Blood Flow; E.M. Nemoto, et al.Skeletal Muscle: Oxygen Supply to Exercising Muscle, Roles of Diffusion Limitation and Heterogeneity of Blood Flow; J. Piiper Abstracts. Kidney and Gut: Filtration, Reabsorption and Oxygen in the Kidney;R.C. Blantz Abstracts. Tumor: Abstracts. 110 additional articles. Index.
Content:
Front Matter....Pages i-xx
Local Plasma Convection Can Be Important for Oxygen Release in Tissue Capillaries....Pages 1-6
Formulation and Realization of a Multicompartmental Model for O2-CO2 Coupled Transport in the Microcirculation....Pages 7-15
Analysis of Tissue Diffusivity Using Mathematical Models....Pages 17-29
Computer - Modeling of Oxygen Supply to Cartilage: Addition of a Compartmental Model....Pages 31-39
A Program to Calculate Mixed Venous Oxygen Tension - a Guide to Transfusion?....Pages 41-49
Microcirculation and O2 Exchange through the Skin Surface: A Theoretical Analysis....Pages 51-58
Fractal Approaches to the Microcirculation....Pages 59-60
Recent Advances in Oxygen Measurements Using Phosphorescence Quenching....Pages 61-66
Recovery of Oxygen Distributions in Tissue from Phosphorescence Decay Data....Pages 67-73
A New Phosphorimeter for the Measurement of Oxygen Pressures Using PD-Porphine Phosphorescence....Pages 75-81
Imaging Oxygen Pressure in Tissue in Vivo by Phosphorescence Decay....Pages 83-91
Measurement of Oxygen Pressure in the Heart in Vivo Using Phosphorescence Quenching....Pages 93-97
Detecting Hypoxia in Heart Using Phosphorescence Quenching and 99MTechnetium-Nitroimidazoles....Pages 99-104
Intestinal Ischemia during Hypoxia and Experimental Sepsis as Observed by NADH Videofluorimetry and Quenching of PD-Porphine Phosphorescence....Pages 105-110
Measurements of pO2 in Vivo, Including Human Subjects, by Electron Paramagnetic Resonance....Pages 111-118
Half-Life of Perfluorooctylbromide in Inner Organs Determined by Fast 19F-NMR Imaging....Pages 119-128
Frequency Response by Pulse Reduction for the Analysis of TRS Spectra....Pages 129-134
Frequency Response by Pulse Reduction for the Analysis of TRS Spectra....Pages 135-142
An Automated System for the Measurement of the Response of Cerebral Blood Volume and Cerebral Blood Flow to Changes in Arterial Carbon Dioxide Tension Using Near Infrared Spectroscopy....Pages 135-142
Near Infrared Spectroscopy: In Situ Studies of Skeletal and Cardiac Muscle....Pages 143-155
Digital Imaging of The Oxygenation State within an Isolated Single Rat Cardiomyocyte....Pages 157-161
Optical Imaging of Human Breast Cancer....Pages 163-169
Transcutaneous H2 Clearance - A New Least-Invasive Method for Assessing Skin Blood Flow....Pages 171-179
Measurement of Cardio-Respiratory Function Using Single Frequency Inspiratory Gas Concentration Forcing Signals....Pages 181-186
Optical Oxygen Sensor Using Fluorescence Lifetime Measurement....Pages 187-195
Tomographic Time-of-Flight Optical Imaging Device....Pages 197-205
Non-Recursive Linear Algorithms for Optical Imaging in Diffusive Media....Pages 207-214
Results of Optical Imaging of Brain Pathology....Pages 215-223
Forearm Blood Flow Measurement by Near Infrared Spectroscopy....Pages 223-223
Object localization in brain and breast by a phased array system....Pages 224-224
Mitochondrial redox state as a “Gold Standard” of tissue hypoxia....Pages 225-225
Development of a Closed Circuit System for Pediatric Anesthesia and On-line VO2 Monitoring....Pages 226-226
Gaseous Oxygen Monitoring Using a Membrane Immobilised Phosphorescence Probe....Pages 227-227
New Intravital Skeletal Muscle Preparation for Oxygen Transport Investigations....Pages 228-228
Very Low Frequency Electron Paramagnetic Resonance Allows the Imaging of Oxygen Concentrations in Distinct Pharmacologic Compartments Deep in Living Tissue....Pages 229-229
Local determination of oxygenation and cell vitality in multicellular spheroids by microelectrodes and photometry....Pages 230-230
Fiber Optic Probe for Near Infra-Red Monitoring of Deep Muscle....Pages 231-231
Intracellular Oxygenation and Redox Status in Muscle....Pages 232-232
Concerted Oxygen-17/Phosphorus-31 Magnetic Resonance Spectroscopy: A Novel Approach for In Vivo Correlation of Oxygen Consumption and Phosphate Metabolism....Pages 233-233
Validation of Near-Infrared Spectroscopy as a Non-Invasive Monitor of Cerebral Metabolism....Pages 234-234
Is Red Cell Flow Heterogeneity a Critical Variable in the Regulation and Limitation of Oxygen Transport to Tissue?....Pages 235-235
Measurements of Hemoglobin Concentration and Oxygen Saturation Profiles in Arterioles using Intravital Videomicroscopy and Image Analysis....Pages 236-236
The Influence of Hypoxic Hypoxia on Coronary Blood Flow Heterogeneity....Pages 237-247
Oxygen Delivery and Intentional Hemodilution....Pages 249-260
Effects of Isovolemic Hemodilution on Microcirculatory Parameters and Skeletal Muscle Oxygenation during Anaesthesia....Pages 261-270
The Role of Endothelium-Derived Relaxing Factor (EDRF) in the Whole Body and Hindlimb Vascular Responses during Hypoxic Hypoxia....Pages 271-278
Critical Oxygen Extraction in Dog Hindlimb after Inhibition of Nitric Oxide Synthase and Cyclooxygenase Systems....Pages 279-284
Intravitreal Perfluorocarbon and Oxygen Delivery in Induced Retinal Ischaemia....Pages 285-293
Whole Animal, Lung and Muscle Hemodynamics and Function are Maintained during and after OxygentTM HT Infusion....Pages 295-301
The Interaction of Acteoside with Mitochondrial Lipid Peroxidation as an Ischemia/Reperfusion Injury Model....Pages 303-311
Ischemia Reperfusion Damage in the Gut and Its Treatment with Drugs of the Aminosalicylic Acid Group....Pages 313-318
Gastric Intramucosal Acidosis During Weaning from Mechanical Ventilation....Pages 319-325
Alterations in Erythrocyte Deformability Under Hypoxia: Implications for Impaired Oxygen Transport....Pages 327-332
The Haldane Effect Under Different Acid-Base Conditions in Premature and Adult Humans....Pages 333-343
The Proton Bohr Factor of Native and Crosslinker Treated Hemoglobins - Its Possible Significance for the Efficacy of Hemoglobin Based Artificial Oxygen Carriers....Pages 345-351
Methods for Measuring Levels of O2 in Tissues....Pages 353-361
Partial Substitution of Red Blood Cells with Free Hemoglobin Solution Does Not Improve Maximal O2 Uptake of Working In Situ Dog Muscle....Pages 363-370
Dependance of Oxygen Delivery on Hematocrit....Pages 371-374
Moderate Anemia Does Not Decrease Subcutaneous Tissue Oxygen Tension in Rabbits....Pages 375-378
Mechanism of Tissue Oxygen Transport Enhancement by Fluorocarbon Blood Substitutes at Normal Hematocrit....Pages 379-380
Effects of Perflubron Emulsion (An Enhancer of Oxygen Carriage in Plasma) on Oxygen Transport in the Anemic Anesthetized Dog....Pages 381-381
Determinants of Red Cell Motion in the Microcirculation....Pages 382-382
Ischemia, Reperfusion, and White Blood Cell Function in the Microcirculation....Pages 383-383
Relaxing and Contracting Factors in the Microcirculation....Pages 384-384
Assessment of Organ Function in Multiple System Organ Failure....Pages 385-385
Active Amino Acid Transport and Oxygen Metabolism in the Perfused Human Placental Lobule....Pages 386-386
Placental Propranolol Metabolism in Normoxia and Hypoxia....Pages 387-387
Capnographic Curve and Cardiac Output Measurement in Critically Ill Patients....Pages 388-388
Effects of Energy Demand in Ischemic and in Hypoxemic Isolated Rat Hearts....Pages 389-389
Effect of Perfusion Pressure on Regional Myocardial Oxygen Consumption and End-Diastolic Segment Length in Swine Myocardium....Pages 390-390
A New Approach for Quantitative Evaluation of Coronary Capillaries in Longitudinal Sections....Pages 391-391
Misinterpretation of Coronary Cholesterol Atheromata in Cholesterol-Fed Rabbits as Suitable Model for Conventional Human Coronary Plaques....Pages 393-399
Functional Heterogeneity of the Heart....Pages 401-406
Respiratory Gas Exchange and Inert Gas Retention during Partial Liquid Ventilation....Pages 407-415
Effects of Different Mechanical Ventilation Modes on Oxygenation in Surfactant Depleted Rabbit Lungs....Pages 417-424
Effect of Ketanserine on Oxygenation and Ventilation Inhomogeneity in Pigs with ARDS....Pages 425-425
Effect of Continuous Rotation on the Efficacy of Partial Liquid (Perflubron) Breathing in Canine Acute Lung Injury....Pages 427-435
Constriction and Dilatation of Pulmonary Arterial Ring by Hydrogen Peroxide - Importance of Prostanoids -....Pages 437-442
Functional Heterogeneity in the Lungs....Pages 443-447
Influence of Intratracheal Perflubron Vapor on Lung Mechanics and Blood Gases....Pages 449-456
Influence of Perflubron Vapor on Pulmonary Gas Trapping and Surface Tension after Intravenous Pfob-Emulsion Administration....Pages 457-463
Effect of Mild Hypothermia on Active and Basal Cerebral Oxygen Metabolism and Blood Flow....Pages 465-465
Investigation of the Effects of Hypocapnia upon Cerebral Haemodynamics in Normal Volunteers and Anaesthetised Subjects by near Infrared Spectroscopy (NIRS)....Pages 466-466
Intraoperative Monitoring of Local Hb-Oxygenation in Human Brain Cortex....Pages 467-468
Slow Waves of Tissue PO2 in the Border Zone of Photothrombotic Brain Infarction and Their Relation to Spreading Depression-Like Events....Pages 469-473
Increased Basic Fibroblastic Growth Factor mRNA in the Brains of Rats Exposed to Hypobaric Hypoxia....Pages 475-482
Oxygen Supply to Exercising Muscle: Roles of Diffusion Limitation and Heterogeneity of Blood Flow....Pages 483-489
Does Energy Demand Have an Additional Control in Ischemia or are Current Models of Metabolic Control Adequate at Extremes....Pages 491-496
Red Blood Cell Transit Time in Man: Theoretical Effects of Capillary Density....Pages 497-502
Capillarisation, Fibre Types and Myoglobin Content of the Dog Gracilis Muscle....Pages 503-507
Leukocyte-endothelium interaction in the microvasculature of Postischemic striated muscle....Pages 509-520
Flow Characteristics of Erythrocytes Subjected to Prolonged Incubation in PBS....Pages 521-532
Effect of electrostatic force on Erythrocyte deformation in narrow capillaries....Pages 533-539
Exercise in Patients with Intermittent Claudication Results in the Generation of Oxygen Derived Free Radicals and Endothelial Damage....Pages 541-545
Training, Immobilization, and Structure-Function Relationships in Dog Gastrocnemius Muscle....Pages 547-553
Cryogenic Microspectrophotometry of Myoglobin....Pages 555-563
Tissue Oxygen Tension Indicates Tissue Oxygen Debt During Progressive Ischemia. an Experimental Study.....Pages 565-570
Intravenous Potassium Infusion Reverses Skeletal Muscle Fatigue....Pages 571-571
Tissue Morphometry: Information Content and Limitations....Pages 572-572
Assessment of Metabolic State in Localized Regions of Resting Skeletal Muscle....Pages 573-573
Symmorphosis or Dysmorphosis?....Pages 574-574
Filtration, Reabsorption and Oxygen in The Kidney....Pages 575-575
Restriction of Hypoxic Membrane Defect by Glycine Improves Mitochondrial and Cellular Function in Reoxygenated Renal Tubules....Pages 576-576
Oxygen Sensing by H2O2-Generating Heme Proteins ?....Pages 577-577
Perfused Rat Liver Responses to Crude Venoms from Marine Snails....Pages 578-578
Gastric Intramucosal pH Measurements as an Index of Tissue Oxygenation in Patients with Sepsis Syndrome....Pages 579-584
Influence of Norepinephrine on the Oxygen Supply,Tissue PO2 and Lactate Extraction Rate of the Liver in the Septic Pig....Pages 585-589
Functional Heterogeneity in the Gut: Relevance to Oxygen Transport and the Maintenance of Oxygen Consumption....Pages 591-595
Do Changes in Tumor Blood Flow Necessarily Lead to Changes in Tissue Oxygenation and in Bioenergetic Status?....Pages 597-601
Computerized Histographic Characterization of Changes in Tissue pO2 Induced by Erythropoietin....Pages 603-603
Glucose Diffusion Coefficients Determined from Concentration Profiles in Emt6 Tumor Spheroids Incubated in Radioactively Labeled L-Glucose....Pages 604-604
Investigations of Perfusion-Limited Hypoxia and Oxygenation in the KHT Sarcoma....Pages 605-605
The Combination of Nicotinamide and Carbogen Breathing to Improve Tumour Oxygenation Prior to Radiation Treatment....Pages 607-611
Assessment of Intracellular Oxygenation of Solid Tumors....Pages 613-618
Back Matter....Pages 619-625
....Pages 627-634