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This book deals with the mechanism of signal transduction in vertebrate and invertebrate photoreceptors. It contains contributions on the structure and function of rhodopsin or other G-coupled receptors, on the regulation of second messengers by enzyme cascade, the role of Ca2+ in light adaptation, control of ionic channels in photoreceptor cells. Some key points: Rhodopsin - structure and function; transducin and phosphodiesterase; arrestin and kinase; cGMP-gated channel; role of Ca2+ in photoreceptors; transduction in invertebrates; eyes of halobacteria


This book deals with the mechanism of signal transduction in vertebrate and invertebrate photoreceptors. It contains contributions on the structure and function of rhodopsin or other G-coupled receptors, on the regulation of second messengers by enzyme cascade, the role of Ca2+ in light adaptation, control of ionic channels in photoreceptor cells. Some key points: Rhodopsin - structure and function; transducin and phosphodiesterase; arrestin and kinase; cGMP-gated channel; role of Ca2+ in photoreceptors; transduction in invertebrates; eyes of halobacteria
Content:
Front Matter....Pages II-XI
Hermann K?hn — In Memoriam....Pages 1-10
Front Matter....Pages 11-11
The Eyes of Halobacteria....Pages 13-18
Front Matter....Pages 19-19
Mutagenesis Studies of Rhodopsin Phototransduction....Pages 21-30
Structural Stability of Rhodopsin and Opsin Studied by Differential Scanning Calorimetry....Pages 31-41
Molecular Analysis of Photoreceptor Protein Function....Pages 42-59
Octopus Rhodopsin....Pages 60-67
Front Matter....Pages 69-69
The Activation of Transducin: Studies on its Mechanism and Modulation....Pages 71-102
The Transitory Complexes Between Photoexcited Rhodopsin and Transducin. Biochemical and Spectroscopic Studies....Pages 103-118
The Rate of GTP Hydrolysis by Transducin and the Termination of the cGMP Cascade in Retinal Rods....Pages 119-131
The Molecular Biology of the Rod Photoreceptor cGMP Phosphodiesterase ?- and ?-Subunits....Pages 132-146
Front Matter....Pages 149-149
The Phosphorylation of Rhodopsin....Pages 151-159
Mechanisms of ?-Adrenergic Receptor Desensitization....Pages 160-171
Front Matter....Pages 173-173
Gating Kinetics of the cGMP-Activated Conductance of Retinal Cones....Pages 175-179
Molecular Properties of the cGMP-gated Cation Channel of Rod Photoreceptor Cells as Probed with Monoclonal Antibodies....Pages 180-194
Cyclic Nucleotide-gated Channels — A Family of Proteins Involved in Vertebrate Photoreception and Olfaction....Pages 195-213
Front Matter....Pages 215-215
Interactions Between Calcium and cGMP in Dialyzed Detached Retinal Rod Outer Segments....Pages 217-235
The Role of Cytoplasmic Calcium Concentration in Photoreceptor Light Adaptation....Pages 236-258
Photoreceptor Guanylate Cyclase and Its Regulation by Calcium....Pages 259-267
Cyclic-GMP Phosphodiesterase in Photoreceptor Cells in Limulus Ventral Eye....Pages 271-280
Glycosylation of Dipteran Opsins During Membrane Biogenesis....Pages 281-298
Back Matter....Pages 299-307
....Pages 308-314
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