Ebook: Calcium in Muscle Contraction: Cellular and Molecular Physiology

Recent years have witnessed an explosion of knowledge lea- ding to a molecular understanding of the mechanisms of ac- tion of calcium on excitation and contraction coupling and its role in the regulation of contractility. This book highlights the most recent progress as well as providing a historial perspective of the field. It presents a concise and comprehensive overview of our current knowledge regar- ding calcium channels and regulatory proteins as well as in- tracellular calcium handling and the mechanisms underlying the activation of contractile proteins. It also describes how these basic mechanisms have been adapted in various types of muscle, especially in cardiac and smooth muscle.

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Recent years have witnessed an explosion of knowledge lea- ding to a molecular understanding of the mechanisms of ac- tion of calcium on excitation and contraction coupling and its role in the regulation of contractility. This book highlights the most recent progress as well as providing a historial perspective of the field. It presents a concise and comprehensive overview of our current knowledge regar- ding calcium channels and regulatory proteins as well as in- tracellular calcium handling and the mechanisms underlying the activation of contractile proteins. It also describes how these basic mechanisms have been adapted in various types of muscle, especially in cardiac and smooth muscle.

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Recent years have witnessed an explosion of knowledge lea- ding to a molecular understanding of the mechanisms of ac- tion of calcium on excitation and contraction coupling and its role in the regulation of contractility. This book highlights the most recent progress as well as providing a historial perspective of the field. It presents a concise and comprehensive overview of our current knowledge regar- ding calcium channels and regulatory proteins as well as in- tracellular calcium handling and the mechanisms underlying the activation of contractile proteins. It also describes how these basic mechanisms have been adapted in various types of muscle, especially in cardiac and smooth muscle.
Content:
Front Matter....Pages I-XVIII
Introduction....Pages 1-2
Muscle Excitation and Contraction....Pages 3-28
The Sarcoplasmic Reticulum: Storage and Release of Calcium....Pages 29-58
The Dependence of Muscle Contraction and Relaxation on the Intracellular Concentration of Free Calcium Ions....Pages 59-82
Calcium Binding and Regulatory Proteins....Pages 83-114
Diversity of Fast and Slow Striated Muscle....Pages 115-142
Myosin-Linked Regulation of Molluscan Muscle....Pages 143-164
The Vertebrate Heart: Modulation of Calcium Control....Pages 165-200
Vertebrate Smooth Muscle....Pages 201-238
Principles of Calcium Signalling in Muscle....Pages 239-249
Molecular Level Approaches to Excitation-Contraction Coupling in Heart and Skeletal Muscle....Pages 251-287
Back Matter....Pages 289-354

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Recent years have witnessed an explosion of knowledge lea- ding to a molecular understanding of the mechanisms of ac- tion of calcium on excitation and contraction coupling and its role in the regulation of contractility. This book highlights the most recent progress as well as providing a historial perspective of the field. It presents a concise and comprehensive overview of our current knowledge regar- ding calcium channels and regulatory proteins as well as in- tracellular calcium handling and the mechanisms underlying the activation of contractile proteins. It also describes how these basic mechanisms have been adapted in various types of muscle, especially in cardiac and smooth muscle.
Content:
Front Matter....Pages I-XVIII
Introduction....Pages 1-2
Muscle Excitation and Contraction....Pages 3-28
The Sarcoplasmic Reticulum: Storage and Release of Calcium....Pages 29-58
The Dependence of Muscle Contraction and Relaxation on the Intracellular Concentration of Free Calcium Ions....Pages 59-82
Calcium Binding and Regulatory Proteins....Pages 83-114
Diversity of Fast and Slow Striated Muscle....Pages 115-142
Myosin-Linked Regulation of Molluscan Muscle....Pages 143-164
The Vertebrate Heart: Modulation of Calcium Control....Pages 165-200
Vertebrate Smooth Muscle....Pages 201-238
Principles of Calcium Signalling in Muscle....Pages 239-249
Molecular Level Approaches to Excitation-Contraction Coupling in Heart and Skeletal Muscle....Pages 251-287
Back Matter....Pages 289-354
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