Ebook: Physical and Chemical Mechanisms in Molecular Radiation Biology

The fundamental understanding of the production of biological effects by ionizing radiation may well be one of the most important scientific objectives of mankind; such understanding could lead to the effective and safe utilization of the nuclear energy option. In addition, this knowledge will be of immense value in such diverse fields as radiation therapy and diagnosis and in the space program. To achieve the above stated objective, the U. S. Department of Energy (DOE) and its predecessors embarked upon a fundamental interdisciplinary research program some 35 years ago. A critical component of this program is the Radiological and Chemical Physics Program (RCPP). When the RCPP was established, there was very little basic knowledge in the fields of physics, chemistry, and biology that could be directly applied to understanding the effects of radiation on biological systems. Progress of the RCPP program in its first 15 years was documented in the proceedings of a conference held at Airlie, Virginia, in 1972. At this conference, it was clear that considerable progr:ess had been made in research on the physical and chemical processes in well-characterized systems that could be used to understand biological effects. During this period of time, most physical knowledge was obtained for the gas phase because the technology and instru­ mentation had not progressed to the point that measurements could be made in liquids more characteristic of biological materials.

---

Introduction to the Problem: The Molecular Biology of Radiation Carcinogenesis; E.J. Hall, G.A. Freyer.Radiological Physics: Atomic and Molecular Theory; M. Inokuti. Charged Particle Transport in the Condensed Phase; M. Zaider. Radial Distribution of Dose; R. Katz, M.N.Varma.Early Chemical Events: Radiation Interactions in High-Pressure Gases; L.G. Christophorou. The Chemistry of Free-RadicalMediated DNA Damage; C. von Sonntag.Models of Radiation Effects: Phenomenological Models; L.A. Braby. Mechanistic Models; S.B. Curtis. Carcinogenesis Models; S.H. Moolgavkar.Molecular Radiation Biology: DNA Damage and Repair; J.F. Ward. Structure-Function Relations in Radiation Damaged DNA; R. Osman, et al. Exciton Microscopy and Reaction Kinetics in Restricted Spaces; R. Kopelman. 6 additional articles. Index.

---

Introduction to the Problem: The Molecular Biology of Radiation Carcinogenesis; E.J. Hall, G.A. Freyer.Radiological Physics: Atomic and Molecular Theory; M. Inokuti. Charged Particle Transport in the Condensed Phase; M. Zaider. Radial Distribution of Dose; R. Katz, M.N.Varma.Early Chemical Events: Radiation Interactions in High-Pressure Gases; L.G. Christophorou. The Chemistry of Free-RadicalMediated DNA Damage; C. von Sonntag.Models of Radiation Effects: Phenomenological Models; L.A. Braby. Mechanistic Models; S.B. Curtis. Carcinogenesis Models; S.H. Moolgavkar.Molecular Radiation Biology: DNA Damage and Repair; J.F. Ward. Structure-Function Relations in Radiation Damaged DNA; R. Osman, et al. Exciton Microscopy and Reaction Kinetics in Restricted Spaces; R. Kopelman. 6 additional articles. Index.
Content:
Front Matter....Pages i-x
Front Matter....Pages 1-1
The Molecular Biology of Radiation Carcinogenesis....Pages 3-25
Front Matter....Pages 27-27
Atomic and Molecular Theory....Pages 29-50
Atomic and Molecular Physics in the Gas Phase....Pages 51-97
Radiation Interactions and Energy Transport in the Condensed Phase....Pages 99-135
Charged-Particle Transport in the Condensed Phase....Pages 137-162
Radial Distribution of Dose....Pages 163-180
Front Matter....Pages 181-181
Radiation Interactions in High-Pressure Gases....Pages 183-230
Energy Transfer, Charge Transfer, and Proton Transfer in Molecular Composite Systems....Pages 231-255
Early Chemical Events and Initial DNA Damage....Pages 257-285
The Chemistry of Free-Radical-Mediated DNA Damage....Pages 287-321
Front Matter....Pages 323-323
The Radiobiological Significance of Spatial and Temporal Distribution of Energy Absorbed from Ionizing Radiations....Pages 325-337
Phenomenological Models....Pages 339-365
Mechanistic Models....Pages 367-386
Carcinogenesis Models: An Overview....Pages 387-399
Front Matter....Pages 401-401
DNA Damage and Repair....Pages 403-421
Structure-Function Relations in Radiation Damaged DNA....Pages 423-452
Chemical, Molecular Biology, and Genetic Techniques for Correlating DNA Base Damage Induced by Ionizing Radiation with Biological End Points....Pages 453-474
Exciton Microscopy and Reaction Kinetics in Restricted Spaces....Pages 475-502
Front Matter....Pages 503-503
Summary....Pages 505-512
Back Matter....Pages 513-517

---

Introduction to the Problem: The Molecular Biology of Radiation Carcinogenesis; E.J. Hall, G.A. Freyer.Radiological Physics: Atomic and Molecular Theory; M. Inokuti. Charged Particle Transport in the Condensed Phase; M. Zaider. Radial Distribution of Dose; R. Katz, M.N.Varma.Early Chemical Events: Radiation Interactions in High-Pressure Gases; L.G. Christophorou. The Chemistry of Free-RadicalMediated DNA Damage; C. von Sonntag.Models of Radiation Effects: Phenomenological Models; L.A. Braby. Mechanistic Models; S.B. Curtis. Carcinogenesis Models; S.H. Moolgavkar.Molecular Radiation Biology: DNA Damage and Repair; J.F. Ward. Structure-Function Relations in Radiation Damaged DNA; R. Osman, et al. Exciton Microscopy and Reaction Kinetics in Restricted Spaces; R. Kopelman. 6 additional articles. Index.
Content:
Front Matter....Pages i-x
Front Matter....Pages 1-1
The Molecular Biology of Radiation Carcinogenesis....Pages 3-25
Front Matter....Pages 27-27
Atomic and Molecular Theory....Pages 29-50
Atomic and Molecular Physics in the Gas Phase....Pages 51-97
Radiation Interactions and Energy Transport in the Condensed Phase....Pages 99-135
Charged-Particle Transport in the Condensed Phase....Pages 137-162
Radial Distribution of Dose....Pages 163-180
Front Matter....Pages 181-181
Radiation Interactions in High-Pressure Gases....Pages 183-230
Energy Transfer, Charge Transfer, and Proton Transfer in Molecular Composite Systems....Pages 231-255
Early Chemical Events and Initial DNA Damage....Pages 257-285
The Chemistry of Free-Radical-Mediated DNA Damage....Pages 287-321
Front Matter....Pages 323-323
The Radiobiological Significance of Spatial and Temporal Distribution of Energy Absorbed from Ionizing Radiations....Pages 325-337
Phenomenological Models....Pages 339-365
Mechanistic Models....Pages 367-386
Carcinogenesis Models: An Overview....Pages 387-399
Front Matter....Pages 401-401
DNA Damage and Repair....Pages 403-421
Structure-Function Relations in Radiation Damaged DNA....Pages 423-452
Chemical, Molecular Biology, and Genetic Techniques for Correlating DNA Base Damage Induced by Ionizing Radiation with Biological End Points....Pages 453-474
Exciton Microscopy and Reaction Kinetics in Restricted Spaces....Pages 475-502
Front Matter....Pages 503-503
Summary....Pages 505-512
Back Matter....Pages 513-517
....